A5045293512- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Reconstructive Surgery and Microvascular Techniques
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Eating Disorders and Behaviors
- Multiple Myeloma Research and Treatments
- Obstructive Sleep Apnea Research
- Dysphagia Assessment and Management
- Cancer-related Molecular Pathways
- Nasal Surgery and Airway Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Voice and Speech Disorders
- Tracheal and airway disorders
- Reconstructive Facial Surgery Techniques
- Histone Deacetylase Inhibitors Research
- Immunodeficiency and Autoimmune Disorders
- Cerebral Venous Sinus Thrombosis
- Glycosylation and Glycoproteins Research
- Osteoarthritis Treatment and Mechanisms
- Cardiac electrophysiology and arrhythmias
- Breast Implant and Reconstruction
- Wnt/β-catenin signaling in development and cancer
- Infectious Diseases and Mycology
Vanderbilt University Medical Center
2023-2025
Stanford University
2024
The University of Texas Southwestern Medical Center
2019-2022
University of New Mexico
2021
Southwestern Medical Center
2019
Creative Commons
2019
Children's Hospital of Philadelphia
2017-2019
Amgen (United States)
2010
Abstract Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. β-catenin widely thought to be a major oncogene in HCC based on frequency mutations associated with aberrant Wnt signaling patients. Challenging this model, our data reveal that nuclear accumulation restricted late stage disease. Until then, primarily located at plasma membrane complex multiple cadherin family members where it drives tumor cell survival by enhancing growth factor receptors...
Background: Nasal defects following Mohs resection are a reconstructive challenge, demanding aesthetic and functional considerations. Many modalities available, each with varying utility efficacy. The goal of this study was to provide an algorithmic approach nasal reconstruction illustrate lessons learned from decades reconstructing defects. Methods: A retrospective review conducted consecutive patients who underwent after excision 2003 2019 performed by the senior author (J.F.T.). Data were...
Abstract We present primary results from the phase 1b GO29754 study evaluating safety and tolerability of atezolizumab, a programmed death-ligand 1 inhibitor, alone in combination with azacitidine, hypomethylating agent (HMA), patients relapsed/refractory (R/R) or HMA-naïve myelodysplastic syndrome (MDS). Patients R/R MDS received atezolizumab for 12 months (cohort A) plus azacitidine 6 cycles followed by as maintenance 8 B). until loss clinical benefit C). Safety, activity, exploratory end...
Prolonged exit from quiescence by hematopoietic stem cells (HSCs) progressively impairs their homeostasis in the bone marrow through an unidentified mechanism. We show that Rb proteins, which are major enforcers of quiescence, maintain HSC positively regulating thrombopoietin (Tpo)-mediated Jak2 signaling. family protein inactivation triggers progressive E2f-mediated transactivation Socs3, a potent inhibitor signaling, cycling HSCs. Aberrant activation Socs3 Tpo signaling and leads to...
The Aurora family of serine-threonine kinases are essential regulators cell division in mammalian cells. Aurora-A and -B expression kinase activity is elevated a variety human cancers associated with high proliferation rates poor prognosis. AMG 900 highly potent selective pan-aurora inhibitor that has entered clinical evaluation adult patients advanced cancers. In mice, oral administration blocks the phosphorylation histone H3 on serine-10 (p-Histone H3), proximal substrate aurora-B inhibits...
Abstract Background Feeding and eating disorders present with a variety of medical complications, some which may be life-threatening. Emergency Medicine (EM) physicians interact patients disorders, however, EM physicians’ knowledge perceptions resources for treating have not been examined. The purpose this study was to explore previous training/education, available resources, educational needs in practicing physicians. Methods An investigator-developed survey used cross-sectional pilot...
This phase 1 b study evaluated the safety, efficacy, and pharmacokinetics of atezolizumab in combination with guadecitabine patients relapsed/refractory (R/R) or first-line acute myeloid leukemia (AML). Patients received 840 mg (days [D] 8 22) 60 mg/m2 (D1 D5) over 28-day cycles. Sixteen (median age 73.0 years) enrolled (R/R cohort, n = 11; 5). All reported at least AE; 15 (93.8%) grade ≥ 3 AEs, SAEs. Fourteen 16 (87.5%) died during trial period due to disease progression (8/14) AEs (6/14),...
Congenital bilateral vocal fold paralysis (BVFP) is a rare but significant cause of morbidity in pediatric otolaryngology. The differential diagnosis expansive, with common etiologies including birth trauma, brainstem neoplasms, and neurologic disorders. There are few known genetic causes the condition. This report details first case BVFP secondary to deficiency MYOD1, master transcriptional regulator skeletal muscle cell specification. Genetics consultation testing may be useful adjunct...
Objective To assess endoscopic and microscopic ossiculoplasty audiometric outcomes. Study Design Retrospective review. Setting Tertiary academic center. Patients Adult patients who underwent with either partial ossicular replacement prosthesis (PORP) or total (TORP) from 2010 to 2019 at least 1 year of follow-up were included. Interventions Endoscopic ossiculoplasty. Main Outcome Measures Postoperative air-bone gap (ABG) after year. Results A 198 patients, 53.5% female, a median age 47.5...
To report hearing preservation (HP) outcomes based on anticoagulation/antiplatelet use (blood thinner, BT) following cochlear implantation (CI).
Congenital hypothyroidism rarely causes a clinically significant neck mass in newborns. We present the case of newborn with congenital and significantly enlarged goiter discuss imaging considerations medical surgical management. This infant was prenatally discovered to have midline on 28 week ultrasound measuring 6.0 cm × 3.4 5.8 cm. Diagnostic cordocentesis demonstrated elevated thyroid-stimulating hormone (TSH, 361 µIU/mL). Maternal evaluation for thyroid disease antithyroid antibodies...
Abstract Background: Eating disorders, specifically anorexia nervosa, have one of the highest mortality rates all mental illnesses.(1) Knowledge and perceptions patients with eating disorders (ED) in Emergency Medicine (EM) specialty is not explored. EM physicians may be first or only provider a patient interacts with. The purpose this study to explore previous training/education, available resources, educational needs treating practicing physicians. Methods: A 36-question...