A5045286361- Salivary Gland Tumors Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Thyroid Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Thyroid and Parathyroid Surgery
- Head and Neck Surgical Oncology
- Head and Neck Anomalies
- Genomics and Rare Diseases
- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Glioma Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Protein Tyrosine Phosphatases
- Silk-based biomaterials and applications
- Myasthenia Gravis and Thymoma
- Genomic variations and chromosomal abnormalities
- Thyroid Disorders and Treatments
- Cervical and Thoracic Myelopathy
- Meta-analysis and systematic reviews
- Dysphagia Assessment and Management
- Infection Control and Ventilation
- Spine and Intervertebral Disc Pathology
- Global Health and Surgery
Vanderbilt University Medical Center
2022-2025
Harvard University
2020-2023
Massachusetts Eye and Ear Infirmary
2023
Harvard–MIT Division of Health Sciences and Technology
2020
University of California, San Francisco
2016-2019
UCSF Benioff Children's Hospital
2016
Abstract High hyperdiploidy (HD) is the most common cytogenetic subtype of childhood acute lymphoblastic leukemia (ALL), and a higher incidence HD has been reported in ALL patients with congenital cancer syndromes. We assessed frequency predisposing germline mutations 57 HD‐ALL from California Childhood Leukemia Study via targeted sequencing cancer‐relevant genes. Three out (5.3%) harbored confirmed that were likely causal, NBN , ETV6 FLT3 an additional six (10.5%) harboring putative rare...
Key Points Some germline variants are predicted to disrupt protein function in HLH-associated genes. Such neither enriched adult-onset HLH nor associated with specific clinical or laboratory features of HLH.
Objectives (1) To estimate the association between neck dissection lymph node yield (LNY) and survival among patients with surgically treated human papilloma virus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC). (2) identify a clinically relevant quality metric for surgical treatment of HPV‐related OPSCC. Study Design Retrospective cohort study. Setting National Cancer Database. Subjects Methods From Database, 4130 were identified HPV‐associated OPSCC primary surgery from...
The RASopathies constitute a diverse group of congenital disorders characterised by short stature, cardiac anomalies, distinctive facial features, predisposition to developing juvenile myelomonocytic leukaemia (JMML) and germline mutations in the Ras-mitogen activated protein kinase (MAPK) pathway.1 We recently described genomic landscape JMML, which can arise context or somatic lesions Ras-MAPK pathway identified RRAS2 as novel lesion JMML.2 thus hypothesised that could be an additional...
(1) Background/Objectives: Delayed esophageal perforation following anterior cervical (spine) discectomy and fusion (ACDF) is rare but can lead to serious infectious complications. The treatment usually involves hardware explanation prolonged intravenous antibiotics; however, there are scarce reports about the microbiology of these infections corresponding targeted therapy. (2) Methods: Patients diagnosed or treated for delayed after between 2000-2020 at a tertiary medical center were...
Congenital hypothyroidism rarely causes a clinically significant neck mass in newborns. We present the case of newborn with congenital and significantly enlarged goiter discuss imaging considerations medical surgical management. This infant was prenatally discovered to have midline on 28 week ultrasound measuring 6.0 cm × 3.4 5.8 cm. Diagnostic cordocentesis demonstrated elevated thyroid-stimulating hormone (TSH, 361 µIU/mL). Maternal evaluation for thyroid disease antithyroid antibodies...
The COVID-19 pandemic has drawn attention to aerosol-generating medical procedures (AGMPs) in health care environments as a potential mode of transmission. Many organizations and institutions have published AGMP safety guidelines, several mention the use simulation informing their recommendations; however, current methods used simulate aerosol generation are heterogenous. Creation high-fidelity, easily producible cough simulator would meet high-priority educational need across all...
Abstract Sub‐Saharan Africa has a high otolaryngologic disease burden exacerbated by an inadequate number of otolaryngologists. The Otolaryngology department at Mbarara University Science & Technology in Uganda is addressing this problem having created Uganda's second national residency training program 2010. We chronicled early period the program's development reporting surgical case quantity and complexity, as defined “key indicator procedure” classification per United States...