A5028838918- Virus-based gene therapy research
- Photodynamic Therapy Research Studies
- HIV Research and Treatment
- Cell Image Analysis Techniques
- Advanced Drug Delivery Systems
- Bacteriophages and microbial interactions
- Genetics, Aging, and Longevity in Model Organisms
- Immune Cell Function and Interaction
- Nanoplatforms for cancer theranostics
- HIV/AIDS drug development and treatment
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Multicomponent Synthesis of Heterocycles
- Spaceflight effects on biology
- biodegradable polymer synthesis and properties
- Electrochemical Analysis and Applications
- Image Processing Techniques and Applications
- Medical Image Segmentation Techniques
- Bacillus and Francisella bacterial research
- AI in cancer detection
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Polyoxometalates: Synthesis and Applications
- Nanocomposite Films for Food Packaging
- Groundwater flow and contamination studies
City University of Hong Kong
2023-2025
Hong Kong Science and Technology Parks Corporation
2024
Daqing Oilfield General Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Beijing University of Technology
2006-2016
Hunan Normal University
1999-2007
Dalian University
2007
Zhejiang Normal University
2002
This study carried out interfacial tension (IFT) testing, sand surface element analysis and scanning electron microscope imaging, rock–oil–emulsification system interaction microstructure, droplet size distribution, stability of oil in water (O/W) emulsion to clarify the porous media flooding mechanism a hydrophilic nano-SiO2 enhanced emulsification system. The results show that by adding small amount (0.01 wt. %) into an anionic surfactant fatty alcohol polyoxyethylene ether sodium...
Short interfering RNAs (siRNAs) are broadly used to manipulate gene expression in mammalian cells. Although chemical modification is useful for increasing the potency of siRNAs vivo, rational optimization siRNA performance through still a challenge. In this work, we designed and synthesized set containing modified two-nucleotide 3′-overhangs with aim strengthening interaction between 3′-end strand PAZ domain Ago2. Their efficiency binding was calculated using computer modeling program,...
Abstract Caenorhabditis elegans has been widely used as a model organism in developmental biology due to its invariant development. In this study, we developed desktop software CShaperApp segment fluorescence‐labeled images of cell membranes and analyze cellular morphologies interactively during C. embryogenesis. Based on the previously proposed framework CShaper, empowers biologists automatically efficiently extract quantitative morphological data with either an existing deep learning or...
ABSTRACT The dynamics of cellular morphology throughout development are crucial for morphogenesis and organogenesis, yet their systematic characterization remains a significant challenge. By integrating both nuclear position advanced cell membrane labeling, we develop novel method that enables the segmentation surfaces over 95% cells produced during Caenorhabditis elegans embryogenesis. With this method, segment eight wild-type four perturbed embryos. output, including identity, shape,...
Due to type-specificity, commercially available human papillomavirus (HPV) vaccines are only effective against homologous HPV serotypes, providing limited protection. Recent studies have highlighted the role of minor capsid protein (known as L2) in inducing cross-protection. The N-terminal peptides L2 contain conserved cross-response epitopes that can induce neutralizing antibodies heterogeneous HPVs. However, when compared with L1, these lower immunogenicity, which limits application...
Hypocrellin B (HB) was encapsulated into a phosphatidylcholine liposome. Encapsulation of HB liposomes not only improved the delivery this photosensitizer but also increased its photodynamic efficacy compared to free molecules. Liposomal showed higher cellular uptake than as measured by confocal microscopy and internalized cultured HeLa cells caveolar endocytosis, which lipid-raft-dependent. Cell viability measurements demonstrated that liposomal more phototoxic result concentration...
Abstract Both cyclic‐voltammetry‐based and impedance‐based experimental criteria that have been developed recently for the oscillatory electrochemical systems are critically appraised with two typical categories of oscillators. Consistent conclusions can be drawn by category oscillators involve coupling charge transfer mainly surface steps ( e.g . ad‐ desorption) such as in electrooxidation C 1 organic molecules. Whereas, criterion is not applicable to mass diffusion convection) Fe(CN) 6 3‐...
Abstract Embryogenesis is the most basic process in developmental biology. Effectively and simply quantifying cell shape challenging for complex dynamic 3D embryonic cells. Traditional descriptors such as volume, surface area, mean curvature often fall short, providing only a global view lacking local detail reconstruction capability. Addressing this, we introduce an effective integrated method, Cell Shape Quantification (3DCSQ), transforming digitized shapes into analytical feature vectors,...
Objective: Limited research has been conducted on the impact of semaglutide bladder cancer in individuals with obesity. Hence, this study employed proteomics conjunction bioinformatics technology to demonstrate that potentially operates through a mechanism reduces likelihood among obese patients. Methods: Thirty-six healthy male C57BL/6J mice were randomly divided into normal diet group (NCD group), high fat (HFD group) and (Sema group). Serum indexes SOD levels measured, tandem mass...
Abstract Motivation Automated cell lineage tracing throughout embryogenesis plays a key role in the study of regulatory control fate differentiation, morphogenesis and organogenesis development animals, including nematode Caenorhabditis elegans. However, automated suffers from an exponential increase errors at late embryo because dense distribution cells, relatively low signal-to-noise ratio (SNR) imbalanced intensity profiles fluorescence images, which demands huge amount human effort to...