A5079615527- Cell death mechanisms and regulation
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- HIV Research and Treatment
Institut de Pharmacologie et de Biologie Structurale
2023
Université de Toulouse
2023
Université Toulouse III - Paul Sabatier
2007-2023
Inserm
2007
Centre de Physiopathologie de Toulouse-Purpan
2007
Macrophages are essential for HIV-1 pathogenesis and represent major viral reservoirs. Therefore, it is critical to understand macrophage infection, especially in tissue macrophages, which widely infected vivo, but poorly permissive cell-free infection. Although cell-to-cell transmission of a determinant mode infection how transfers toward macrophages remains elusive. Here, we demonstrate that fusion CD4+ T lymphocytes with human leads their efficient productive Importantly, several...
The capacity of FasL molecules expressed on melanoma cells to induce lymphocyte apoptosis contributes either antitumor immune response or escape depending their expression level. Little is known, however, about the mechanisms regulating protein expression. Using murine B16F10 model weakly positive for FasL, we demonstrated that in vitro treatment with statins, inhibitors 3-hydroxy3-methylgutaryl CoA reductase, enhances membrane C3 exotoxin and geranylgeranyl transferase I inhibitor GGTI-298,...