A5065539136- HIV Research and Treatment
- Immune Cell Function and Interaction
- Toxoplasma gondii Research Studies
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- HIV/AIDS Research and Interventions
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
Inserm
2022-2023
Institut des Maladies Métaboliques et Cardiovasculaires
2023
Université Toulouse III - Paul Sabatier
2018-2022
Université de Toulouse
2022
Centre National de la Recherche Scientifique
2022
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021
Centre de Physiopathologie de Toulouse-Purpan
2019
Macrophages are essential for HIV-1 pathogenesis and represent major viral reservoirs. Therefore, it is critical to understand macrophage infection, especially in tissue macrophages, which widely infected vivo, but poorly permissive cell-free infection. Although cell-to-cell transmission of a determinant mode infection how transfers toward macrophages remains elusive. Here, we demonstrate that fusion CD4+ T lymphocytes with human leads their efficient productive Importantly, several...
Macrophages (MΦ) are increasingly recognized as HIV-1 target cells involved in the pathogenesis and persistence of infection. Paradoxically, vitro infection assays suggest that virus isolates mostly T-cell-tropic rarely MΦ-tropic. The latter assumed to emerge under CD4+ T-cell paucity tissues such brain or at late stage when CD4 count declines. However, qualify tropism use cell-free viral particles may not fully reflect conditions vivo MΦ through cell-to-cell transfer. Here, we investigated...
HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression AIDS. However, counterexamples this paradigm common, suggesting heterogeneity in virulence viruses. Here, we investigated role CXCR4 CXCL12 as a driving force behind virus virulence. In vitro , prevents from entering CD4TL, but its transmission propagation remains speculative. Through...
Abstract Macrophages (MΦ) are increasingly recognized as HIV-1 target cells involved in the pathogenesis and persistence of infection. Paradoxically, vitro infection assays suggest that virus isolates mostly T-cell-tropic rarely MΦ-tropic. The latter assumed to emerge under CD4+ T-cell paucity tissues such brain or at late stage when CD4 count declines. However, qualify tropism use cell-free viral particles may not fully reflect conditions vivo MΦ through cell-to-cell transfer. Here, we...
Inadequate immune control of Central Nervous System (CNS) pathogens may result in fatal neuroinflammation. CD8 T cells are instrumental for CNS pathogen but the functions brain-resident antigen-presenting remain poorly understood. Here, we analyzed modalities MHC I presentation Toxoplasma gondii, a parasite chronically residing CNS. Using transgenic parasites with stage-restricted expression protective antigen, show that rapidly dividing tachyzoites prevents encephalitis and improper during...