A5090535752- HIV Research and Treatment
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Dermatological and COVID-19 studies
- Blood groups and transfusion
- Multiple Sclerosis Research Studies
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Complement system in diseases
- Cytomegalovirus and herpesvirus research
- HIV/AIDS drug development and treatment
- Hematopoietic Stem Cell Transplantation
- Eosinophilic Disorders and Syndromes
- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Immunodeficiency and Autoimmune Disorders
- Streptococcal Infections and Treatments
- Renal Transplantation Outcomes and Treatments
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- Poxvirus research and outbreaks
- HIV/AIDS Research and Interventions
- Bacterial Infections and Vaccines
- Urticaria and Related Conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
Université de Toulouse
2014-2024
Inserm
2000-2023
Centre Hospitalier Universitaire de Toulouse
2010-2023
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2021-2023
Université Toulouse III - Paul Sabatier
2005-2022
Hôpital Purpan
2000-2022
Centre National de la Recherche Scientifique
2022
Centre Hospitalier Universitaire de Nice
2022
Centre Hospitalier Universitaire de Nîmes
2022
Centre Hospitalier Universitaire de Montpellier
2022
Summary Like mesenchymal stem cells from bone marrow (BM‐MSCs), adipose tissue‐derived adult (ADAS cells) can differentiate into several lineages and present therapeutical potential for repairing damaged tissues. The use of allogenic enlarge their interest, provided that the grafted could be tolerated. We investigate here, first time, immunosuppressive properties ADAS compared with well‐characterized BM‐MSCs. did not provoke in vitro alloreactivity incompatible lymphocytes and, moreover,...
Kappa free light chains (KFLC) seem to efficiently diagnose MS. However, extensive cohort studies are lacking establish consensus cut-offs, notably rule out non-MS autoimmune CNS disorders. Our objectives were (1) determine diagnostic performances of CSF KFLC, KFLC index, and intrathecal fraction (IF) threshold values that allow us separate MS from different disorder control populations compare them with oligoclonal bands' (OCB) (2) identify independent factors associated quantification in...
Objective To investigate the changes in genotypic drug-resistance pattern, plasma HIV RNA and CD4 cell count after treatment interruption assess short-term antiviral effect of a new salvage regimen. Design Prospective study 38 patients with multiple failing regimens who had completely stopped all medication for 3 months before three to five-drug regimen was reintroduced according clinical guidelines. Methods Patients were tested resistance by population-based sequencing clonal analysis...
The impact of HIV infection on regulatory CD4+CD25high (Treg) lymphocyte subpopulations was evaluated by FOXP3 quantitative reverse transcriptase polymerase chain reaction and flow cytometry. mRNA quantified in peripheral blood mononuclear cells or purified CD4+ lymphocytes from HIV+ lymphopenic patients. Patients were distributed among clinical stages A, B, C received highly active antiretroviral therapy. frequency lymphocytes, measured cytometry, decreased patients (n = 38) compared with...
The data presented in this paper are reference ranges for frequencies of thirty-eight subpopulations T, B and NK lymphocytes, established from a cohort 253 healthy blood donors aged 19 to 67. When relevant, the influence age or sex was taken into account calculate these values. This article is related research entitled "Influence age, HCMV-serostatus on lymphocyte adults" (Apoil et al., 2017) [1]. Immunophenotyping obtained each individual made publicly available extended analyses.
An association between hepatitis E virus (HEV) infection and cryoglobulinemia has been suggested. The aims of this study were to assess the prevalence during HEV in solid-organ-transplant (SOT) recipients, describe its outcomes under ribavirin therapy evaluate effects on kidney function histology.Between November 2005 June 2016, 128 cases diagnosed among SOT recipients followed our institution. Cryoglobulinemia data obtained from 66 patients acute-phase 51 chronic-phase compared a historical...
BackgroundType I interferon (IFN-I) production by plasmacytoid dendritic cells (pDCs) occurs during viral infection, in response to Toll-like receptor 7 (TLR7) stimulation and is more vigorous females than males. Whether this sex bias persists ageing people currently unknown. In study, we investigated the effect of aging on IFN-α induced PRR agonist ligands.MethodsIn a large cohort individuals from 19 97 years old, measured inflammatory cytokines whole-blood upon with either R-848, ODN M362...
Recently, it was demonstrated that CD8+ T cells are important for the response against Chlamydia pneumoniae. By use of human monocytic cell line U937 and monocytes taken from peripheral blood, we investigated effect infection on various molecules critical function. A strong secretion interleukin (IL)—10 by infected observed, together with an inhibited expression major histocompatibility complex (MHC) class I antigens, but without significant alteration tumor growth factor—β or MHC II...
Vaccinia virus (VV) vaccination is used to immunize against smallpox and historically was considered have been successful if a skin lesion formed at the site. While antibody responses widely proposed as correlate of efficacy protection in humans, role cellular humoral immunity VV-associated formation unknown. We therefore investigated whether long-term residual immune memory VV, persisting 30 years after vaccination, could control VV-induced revaccinated individuals. Here, we shown that...
We analyzed the impact of age, sex, and CMV on blood monocyte dendritic cell (DC) subpopulations in 256 healthy individuals aged from 19 to 96 years. Flow cytometry was performed whole within 4 h following drawing. Myeloid (mDC) plasmacytoid DC (pDC), classical, intermediate, nonclassical monocytes were enumerated by means TruCount tubes (BD Biosciences). provided reference values for mDC, pDC three subpopulations. The numbers slightly increased with age while mDC did not vary significantly....
Although polymorphisms of chemokine genes (SDF1, stromal cell-derived factor-1 and RANTES, regulated on activation, normal T cell expressed secreted) chemokine-receptor (CCR5, CCR2, CX3CR1) were shown to be associated with sensitivity HIV infection untreated disease progression, their association the response highly active antiretroviral therapy (HAART) remains unclear. To explore possible influence such evolution AIDS in treated patients, we have studied SDF1-3'A, CCR5Δ32, CCR2-64I,...
HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression AIDS. However, counterexamples this paradigm common, suggesting heterogeneity in virulence viruses. Here, we investigated role CXCR4 CXCL12 as a driving force behind virus virulence. In vitro , prevents from entering CD4TL, but its transmission propagation remains speculative. Through...
Abstract : The objective of the study was to investigate influence blood concentrations hydroxychloroquine ([HCQ]) and its derivative desethylhydroxychloroquine ([DHCQ]) on lymphocyte activation or differentiation in HCQ‐treated lupus patients. We studied correlations between [HCQ], [DHCQ], frequency various subsets 58 patients (mean HCQ dose: 4.93 ± 1.58 mg/kg/day; mean duration disease: 122 64 months). [HCQ] [DHCQ] were determined by high‐performance liquid chromatography (HPLC)....
Bacterial recombinant cysteine protease Ides (imlifidase, Idefirix®, Hansa Biopharma) is used to prevent humoral transplant rejection in highly HLA-sensitized recipients, and control IgG-mediated autoimmune diseases. We report the case of a 51 years old woman suffering from lupus nephritis with end stage kidney disease, grafted for second time pre-treated imlifidase. The patient was HLA-hypersensitized (calculated Panel Reactive Antibodies [Abs], cPRA>99 %) has three preformed Donor Specific...