A5101848854- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Lanthanide and Transition Metal Complexes
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Cancer Cells and Metastasis
- Virus-based gene therapy research
- Neurological Disease Mechanisms and Treatments
- HIV Research and Treatment
- Surgical Sutures and Adhesives
- Occupational and environmental lung diseases
- Hemostasis and retained surgical items
- Cancer survivorship and care
- Hepatitis B Virus Studies
- Medicinal Plant Pharmacodynamics Research
- Lung Cancer Research Studies
- Respiratory viral infections research
- Atomic and Subatomic Physics Research
- Advanced NMR Techniques and Applications
- Cancer therapeutics and mechanisms
- Medical Imaging Techniques and Applications
- Oral health in cancer treatment
- Stroke Rehabilitation and Recovery
Chengdu University of Traditional Chinese Medicine
2021-2022
Zhongda Hospital Southeast University
2021
Nanjing Agricultural University
2018-2020
Case Western Reserve University
2014-2017
Shihezi University
2015
National Institute for Viral Disease Control and Prevention
2010
Tianjin Hospital
2009
Beijing University of Chinese Medicine
2008
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2007
High‐field preclinical MRI scanners are now commonly used to quantitatively assess disease status and the efficacy of novel therapies in a wide variety rodent models. Unfortunately, conventional methods highly susceptible respiratory cardiac motion artifacts resulting potentially inaccurate misleading data. We have developed an initial 7.0‐T implementation MR fingerprinting (MRF) methodology which has been described previously for clinical imaging applications. The MRF technology combines...
Arterial spin labeling (ASL) is a valuable non‐contrast perfusion MRI technique with numerous clinical applications. Many previous ASL studies have utilized either echo‐planar imaging (EPI) or true fast steady‐state free precession (true FISP) readouts, which are prone to off‐resonance artifacts on high‐field scanners. We developed rapid ASL‐FISP acquisition for preclinical scanners providing perfusion‐weighted images little no in less than 2 s. In this initial implementation, flow‐sensitive...
Dystrophin, the main component of dystrophin–glycoprotein complex, plays an important role in maintaining structural integrity cells. It is also involved formation blood–brain barrier (BBB). To elucidate impact dystrophin disruption vivo, we characterized changes cerebral perfusion and diffusion dystrophin-deficient mice (mdx) by magnetic resonance imaging (MRI). Arterial spin labeling (ASL) diffusion-weighted MRI (DWI) studies were performed on 2-month-old 10-month-old mdx their age-matched...
The highly contagious Newcastle disease virus (NDV) continues to threaten poultry all over the world. NDV DNA vaccine is a promising solution current (ND) challenges, and thus an efficient delivery system should be developed facilitate efficacy of vaccines. In this study, we consisting triblock copolymer poly(lactide co-glycolide acid) polyethylene glycol (PLGA-PEG-PLGA) hydrogel in which recombinant hemagglutinin-neuraminidase (HN) plasmid was encapsulated. Its characteristics, security,...
Magnetic resonance imaging (MRI) of glioblastoma multiforme (GBM) with molecular agents would allow for the specific localization brain tumors. Prior studies using T 1-weighted MR demonstrated that SBK2-Tris-(Gd-DOTA)3 agent labeled heterotopic xenograft models tumors more intensely than non-specific contrast conventional techniques. In this study, we used a dynamic quantitative 1 mapping strategy to objectively compare intra-tumoral retention over time in comparison non-targeted control...
Magnetic resonance imaging (MRI) has become an indispensable tool in the diagnosis and treatment of many diseases, especially cancer. However, poor sensitivity MRI relative to other modalities, such as PET, hindered development clinical use molecular contrast agents that could provide vital diagnostic information by specifically locating a target altered disease process. This work describes specific sustained vivo binding retention protein tyrosine phosphatase mu (PTPμ)-targeted, magnetic...
Abstract Anlotinib is a multi‐target tyrosine kinase inhibitor. Previous studies confirmed that anlotinib exerts anti‐cancer efficiency. However, the functional roles of on cancer stem cells (CSCs) are yet to be elucidated. In this study, lung CSCs were isolated and identified in vitro, mouse xenografts established vivo. MTT assays, tumour sphere formation TdT‐mediated dUTP nick‐end labelling (TUNEL) staining, Annexin V‐FITC/PI immunofluorescence analysis Western blot performed investigate...
Autosomal recessive polycystic kidney disease (ARPKD) is a potentially lethal multi‐organ affecting both the kidneys and liver. Unfortunately, there are currently no non‐invasive methods to monitor liver progression in ARPKD patients, limiting study of potential therapeutic interventions. Herein, we perform an initial investigation T 1 relaxation time as imaging biomarker quantitatively assess two primary pathologic hallmarks disease: biliary dilatation periportal fibrosis PCK rat model...
Sustained-release formulations of ivermectin (IVM) are useful for controlling parasitic diseases in animals. In this work, an IVM bolus made from microcrystalline cellulose (MCC), starch and low-substituted hydroxypropyl (LS-HPC) was optimized by response surface methodology. The dissolved a cup containing 900 mL dissolution medium at 39.5 °C, under with stirring 100 rpm. A quadratic model formulated using analysis variance according to the time. formulation contained 8% MCC, 0.5% starch,...
A novel and sensitive spectrofluorimetric method was developed for the determination of lornoxicam. The based on fluorescence enhancement europium(III) by formation a ternary complex with lornoxicam in presence lysozyme as co-ligand. signal lornoxicam-europium (III)-lysozyme system monitored at an excitation wavelength 620 nm emission 390 nm. parameters affecting intensity were optimized systematically under these conditions directly proportional to concentration from 9.0 × 10−5 1.0 10−2 µg...
Here, we reported the rare case of primary pleural squamous cell carcinoma (PPSCC) in a 71-year-old male patient. After chemo and targeted therapies, patient showed continuous tumor progression clinical deterioration. Fortunately, had high expression level PD-L1 (80%) tissues. Ultimately, survived for additional 6 months with camrelizumab treatment. In summary, may be good candidate treatment PPSCC, especially tumors expression.
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Abstract BackgroundRadical mastectomy may lead to suppression of cellular immune function in patients with malignant tumors, and affect the quality life (QOL) patients. Immune is a common cause complications adverse reactions adjuvant therapy after radical breast cancer. Currently, there are few proven effective treatments for suppression. Therefore, it’s necessary develop new treatment method. Press needle widely used clinical practice. However, have been relatively studies that evaluate...