A5026974350- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Pneumocystis jirovecii pneumonia detection and treatment
- Cancer therapeutics and mechanisms
- Metal complexes synthesis and properties
- Synthesis and biological activity
- Phenothiazines and Benzothiazines Synthesis and Activities
- Catalytic C–H Functionalization Methods
- Computational Drug Discovery Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotic Resistance in Bacteria
- Diagnosis and treatment of tuberculosis
- Antibiotic Use and Resistance
- Synthesis and Catalytic Reactions
- Bioactive Compounds and Antitumor Agents
- Drug Transport and Resistance Mechanisms
- Chemistry and Chemical Engineering
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Ferrocene Chemistry and Applications
- Nanoparticles: synthesis and applications
Universidade Estadual Paulista (Unesp)
2017-2022
Centro Universitário de Araraquara
2019-2020
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the infectious disease responsible for highest number of deaths worldwide. Herein, 22 new N-oxide-containing compounds were synthesized followed in vitro and vivo evaluation their antitubercular potential against Mtb. Compound 8 was found to be most promising compound, with MIC90 values 1.10 6.62 μM active nonreplicating Mtb, respectively. Additionally, we carried out experiments confirm safety efficacy compound 8; orally...
New silver(i) compounds containing 2-formylpyridine-N(4)-R-thiosemicarbazones and 1,10-phenanthroline (phen) were synthesized characterized by spectroscopic techniques (IR NMR), elemental analysis, ESI-MS molar conductance measurements. In these complexes, both phen thiosemicarbazone ligands are coordinated in a chelating bidentate fashion. Compounds 1-3 not only showed good vitro antiproliferative activity against human lung (A549) breast tumor cells (MDA-MB-231 MCF-7), with IC50 values...
The most recent survey conducted by the World Health Organization described Tuberculosis (TB) as one of top 10 causes death and leading cause from a single infectious agent. increasing number TB-resistant cases has contributed to this scenario. In light this, new strategies control treat disease are necessary. Our research group previously furoxan derivatives promising scaffolds be explored antitubercular drugs. Results: Two these derivatives, (14b) (14c), demonstrated high selectivity...
As a biologic reservoir of Mycobacterium tuberculosis (M. tb), one-quarter the world population is infected with well-known latent (LTBI). About 5–10% LTBI patients will progress to active disease in first years after primary infection and, despite using recommended treatment, 20% can still reactivate infection. A new treatment could minimize adverse effects and antibiotic resistance that occur when same drug used treat disease. New hydrazones were evaluated, they showed great inhibitory...
Tuberculosis (TB) is an infectious, airborne disease caused by the bacterium Mycobacterium tuberculosis that mainly affects lungs. Fortunately, a curable disease, and in recent years, death rates for this have decreased. However, existence of antibiotic-resistant strains occurrence co-infections with human immunodeficiency virus (HIV), led to increased mortality years. Another area concern one-third world's population currently infected M. its latent state, serving as potential reservoir...