A5033852786- Bone health and osteoporosis research
- Bone health and treatments
- Bone and Joint Diseases
- Hip and Femur Fractures
- Bone fractures and treatments
- Bone Metabolism and Diseases
- Vitamin D Research Studies
- Hip disorders and treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Analysis
- Body Composition Measurement Techniques
- Orthopaedic implants and arthroplasty
- Parathyroid Disorders and Treatments
- Pain Mechanisms and Treatments
- Diet and metabolism studies
- Nutrition and Health in Aging
- Connective tissue disorders research
- Muscle activation and electromyography studies
- Regulation of Appetite and Obesity
- Diabetes and associated disorders
- Cardiac Fibrosis and Remodeling
- Cardiovascular and exercise physiology
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Lower Extremity Biomechanics and Pathologies
University of Sheffield
2015-2025
Insigneo
2018-2024
United States Bone and Joint Initiative
2005-2018
Northern General Hospital
2009-2017
Sheffield Teaching Hospitals NHS Foundation Trust
2012-2014
Sanofi (France)
2013
Roche (Switzerland)
2013
Eli Lilly (United States)
2013
Pfizer (United Kingdom)
2013
Novartis (Switzerland)
2013
ABSTRACT Obesity is associated with greater areal BMD (aBMD) and considered protective against hip vertebral fracture. Despite this, there a higher prevalence of lower leg proximal humerus fracture in obesity. We aimed to determine if are site-specific differences BMD, bone structure, or strength between obese normal-weight adults. studied 100 individually-matched pairs normal (body mass index [BMI] 18.5 24.9 kg/m2) (BMI >30 men women, aged 25 40 years 55 75 years. assessed aBMD at...
Background Renal osteodystrophy is common in advanced CKD, but characterization of bone turnover status can only be achieved by histomorphometric analysis biopsy specimens (gold standard test). We tested whether biomarkers and high-resolution peripheral computed tomography (HR-pQCT) parameters predict determined histomorphometry. Methods obtained fasting blood samples from 69 patients with CKD stages 4–5, including on dialysis, 68 controls for biomarker (intact parathyroid hormone [iPTH],...
Bone mass is low and fracture risk higher in obese children. Hormonal changes relation to skeletal microstructure biomechanics have not been studied children.The objective of the study was ascertain relationships obesity-related hormones with biomechanics.High resolution peripheral quantitative computed tomography (HR-pQCT) used compare three-dimensional cortical trabecular at load-bearing nonload bearing sites lean The relationship between leptin, adiponectin, testosterone, estrogen,...
Areal bone mineral density (aBMD) currently represents the clinical gold standard for hip fracture risk assessment. Nevertheless, it is characterised by a limited prediction accuracy, as about half of people experiencing are not classified at being aBMD. In context progressively ageing population, identification accurate predictive tools would be pivotal to implement preventive actions. this study, DXA-based statistical models proximal femur shape, intensity (i.e., density) and their...
Androgen deprivation therapy (ADT) for localised and metastatic prostate cancer (PCa) is known to improve survival in patients but has been associated with negative long-term impacts on the skeleton, including decreased bone mineral density (BMD) increased fracture risk. Previously, dual-energy x-ray absorptiometry (DXA) measurements of areal BMD (aBMD) vertebrae. However, a prediction vertebral strength requires information that aBMD cannot provide, such as geometry volumetric (vBMD). This...
Type 1 diabetes mellitus (T1DM) has been linked to increased osteocyte apoptosis, local accumulation of mineralized lacunar spaces, and microdamage suggesting an impairment the mechanoregulation network in affected individuals. Diabetic neuropathy might exacerbate this dysfunction through direct effects on bone turnover, indirect balance, muscle strength, gait. However, vivo impaired remodeling humans remain underexplored. This longitudinal cohort study assessed consenting participants with...
ABSTRACT High bone mass (HBM) can be an incidental clinical finding; however, monogenic HBM disorders (eg, LRP5 or SOST mutations) are rare. We aimed to determine what extent is explained by mutations in known genes. A total of 258 unrelated cases were identified from a review 335,115 DXA scans 13 UK centers. Cases assessed clinically and underwent sequencing anabolic loci: (exons 2, 3, 4), LRP4 25, 26), 1, the van Buchem's disease [VBD] 52-kb intronic deletion 3′). Family members for...
Abstract Adjuvant bisphosphonates are often recommended in postmenopausal women with early breast cancer at intermediate-to-high risk of disease recurrence, but the magnitude and duration their effects on bone mineral density (BMD) turnover markers (BTMs) not well described. We evaluated impact adjuvant zoledronate areal BMD BTMs a sub-group patients who had completed large 5-yr randomized Zoledronic Acid to Reduce Recurrence (AZURE) trial. About 224 (recurrence free) AZURE trial within...
Bone size, geometry, density, and microarchitecture are important determinants of bone strength. By understanding how these properties change during skeletal development, we can better understand fragility.The aim the study was to compare microarchitecture, strength radius tibia in men women at end adolescence young adulthood relate biochemical turnover markers regulatory hormones.We conducted a cross-sectional 116 healthy ages 16-18 (n = 56) 30-32 60) yr.We used high-resolution peripheral...
High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body index, the basis for which unclear.To investigate why index elevated individuals with HBM, we composition and examined whether differences could be explained phenotypes, eg, and/or turnover.We conducted a case-control study 153 cases unexplained HBM recruited from 4 UK centers screening 219 088 DXA scans. A total 138 first-degree relatives (of whom 51 had HBM) 39 spouses...
Fracture risk is increased in type 1 diabetes (T1D). Diabetic neuropathy might contribute to this directly through effects on bone turnover and indirectly balance, muscle strength, gait. We compared patients with T1D (T1DN+, n = 20) without (T1DN-, distal symmetric sensorimotor polyneuropathy controls (n 20). assessed areal mineral density (aBMD) appendicular mass by dual-energy X-ray absorptiometry, microarchitecture high-resolution peripheral quantitative tomography at the standard...
Adults with type 1 diabetes mellitus (T1DM) are at risk of premature osteoporosis and fractures. The onset T1DM typically starts during childhood adolescence. Thus, the effects DM on skeleton may be established this period. Studies in children primarily use DXA conflicting results. We present first study adolescents assessing impact skeletal microstructure strength using HRpQCT. recruited 22 patients aged 12 to 16 years who were matched by age, gender, pubertal stage healthy controls. Paired
Obese (OB) adults (BMI ≥ 30) have a higher bone mineral density (BMD) and more favourable microarchitecture than normal-weight (NW) 18.5-24.9).The objective of this study was to identify which fat compartments the strongest association with turnover whether biochemical factors (adipokines, hormones regulators) are likely be important mediators effect obesity on bone.This cross-sectional, observational, matched case-control study.Participants were recruited from local community.Two hundred...
Recently, coupled musculoskeletal-finite element modelling approaches have emerged as a way to investigate femoral neck loading during various daily activities. Combining personalised gait data with finite models will not only allow us study changes in motion/movement, but also their effects on critical internal structures, such the femur. However, previous studies been hampered by small sample size and lack of fully order construct model. Therefore, aim this was build pipeline for...
Androgen Deprivation Therapy (ADT) for prostate cancer (PC) has substantial negative impacts on the musculoskeletal system and body composition. Many studies have focused effects of ADT areal bone mineral density (aBMD), but aBMD does not capture key determinants strength fracture risk, example volumetric (vBMD), geometry, cortical thickness porosity, trabecular parameters rate remodelling. More specialist imaging techniques such as high-resolution peripheral quantitative computed tomography...