<h3>Importance</h3> Management of the primary tumor site in patients with metastatic breast cancer remains controversial. <h3>Objective</h3> To evaluate patterns receipt initial surgery for female stage IV United States, particular attention to women who survived at least 10 years. <h3>Design, Setting, and Participants</h3> A retrospective cohort study using data from Surveillance, Epidemiology, End Results (SEER) program. Female diagnosed as having between 1988 2011 did not receive...

Metaplastic breast cancer (MBC) is a rare disease subtype characterized by an aggressive clinical course. MBC commonly triple negative (TN), although hormone receptor (HR) positive and human epidermal growth 2 (HER2) cases do occur. Previous studies have reported similar outcomes for with regard to HR status. Less known about HER2 MBC.Surveillance, Epidemiology, End Results Program data were used identify women diagnosed 2010-2014 or invasive ductal carcinoma (IDC). Kaplan-Meier curves...

Primary breast lymphoma (PBL) has gained attention with the description of implant-associated anaplastic large cell (ALCL). Less is known about PBL incidence, treatment, and survival by subtype.The Surveillance, Epidemiology, End Results (SEER) registry database was queried for patients as first malignancy, to non-Hodgkin Lymphoma subtypes: diffuse B-cell (DLBCL), follicular lymphoma, marginal zone (MZL), ALCL. Incidence estimated age subtype joinpoint analyses, along initial local therapy....

Although recent findings suggest that de novo stage IV breast cancer is increasing in premenopausal women the United States, contemporary incidence and survival data are lacking for I-III cancer.Women aged 20-29 (n = 3826), 30-39 34 585), 40-49 126 552) years who were diagnosed with from 2000 to 2015 identified Surveillance, Epidemiology, End Results 18 registries database. Age-adjusted, average annual percentage changes 5- 10-year Kaplan-Meier curves estimated by race ethnicity, stage,...

Preventing Chronic Disease (PCD) is a peer-reviewed electronic journal established by the National Center for Prevention and Health Promotion. PCD provides an open exchange of information knowledge among researchers, practitioners, policy makers, others who strive to improve health public through chronic disease prevention.

ABSTRACT Purpose Differences in breast cancer recurrence and survival occur by body size; the role of treatment differences these disparities has been underexplored. Our objective was to evaluate treatments received, patient experiences care, decision‐making processes among survivors size. Methods We used data from Share Thoughts on Breast Cancer study. Participants ( n = 1198) completed a survey that included information demographics, quality decision‐making. descriptive statistics response...

To estimate the prevalence and risk factors for vitreous floaters in general population.An electronic survey was administered through a smartphone app asking various demographic health questions, including whether users experience their field of vision. Multivariate logistic regression analysis used to determine factors.A total 603 individuals completed survey, with 76% reporting that they see floaters, 33% caused noticeable impairment Myopes were 3.5 times more likely (P=0.0004), hyperopes...

Background Some studies have found that antimicrobials, especially macrolides, increase the risk of cardiovascular death. We investigated potential cardiac‐related events associated with antimicrobial use in a population patients acute myocardial infarction. Methods and Results For 185 010 Medicare beneficiaries, we recorded prescriptions for azithromycin, clarithromycin, levofloxacin, moxifloxacin, doxycycline, amoxicillin‐clavulanate. In following week, death, infarction, atrial...

There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin deficiency was associated with not attaining a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for operable cancer. We report impact on pCR and survival an expanded cohort.Patients from Iowa Montpellier registries who had serum level measured before or during NAC were included....

The Greater Plains Collaborative (GPC) and other PCORnet Clinical Data Research Networks capture healthcare utilization within their health systems. Here, we describe a reusable environment (GPC Reusable Observable Unified Study Environment [GROUSE]) that integrates hospital electronic records (EHRs) data with state-wide Medicare Medicaid claims assess how clinical complement each to identify obesity related comorbidities in patient sample.EHR, billing, tumor registry from 7 systems were...

Objective: To determine factors associated with rectal cancer surgery performed at high-volume hospitals (HVHs) and by surgeons (HVSs), including the roles of rurality diagnostic colonoscopy provider characteristics. Summary Background Data: Although higher-volume hospitals/surgeons often achieve superior surgical outcomes, many resections are lower-volume hospitals/surgeons, especially among rural populations. Methods: Patients age 66+ diagnosed from 2007 to 2011 stage II/III primary...

Objectives To determine whether acute hospitalization is associated with a change in potentially inappropriate medication ( PIM ) use and varies across geographic region. Design Observational. Setting Continental United States. Participants Medicare beneficiaries aged 65 older hospitalized for myocardial infarction (AMI) during 2007–08. Measurements Potentially was defined according to the High‐Risk Medications Elderly Adults quality indicator from Healthcare Effectiveness Data Information...

The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) vs. sub-lobar (SL-R), is controversial. This further explored in this population-based study.The Surveillance, Epidemiology, and End Results (SEER) Program was used to select patients ≥66 years old, diagnosed between 2000 2012 with TC. A similar cohort developed using the SEER-Medicare database (diagnosed from 2000-2007) identify chemotherapy (CTX) use co-morbidity. Five-year survival calculated...

Objectives To determine whether function‐related indicators ( FRI s), derived from preadmission claims data, help explain the frequent practice of forgoing secondary prevention medications observed in Medicare. Design Retrospective cohort. Setting National Medicare data. Participants Elderly beneficiaries discharged alive an acute myocardial infarction AMI ) hospitalization 2007–2008 (N = 184,156). Measurements Study outcomes were number guideline‐recommended (statins, beta‐blockers, and...

Rural patients experience worse cancer survival outcomes than urban despite similar incidence rates, due in part to significant barriers accessing quality care. Community hospitals non-metropolitan/rural areas play a crucial role providing care who desire and are able receive locally. However, rural community typically face challenges comprehensive lack of resources. The University Kentucky's Markey Cancer Center Affiliate Network (MCCAN) is an effective complex, multi-level intervention,...

An aging population, with its associated rise in cancer incidence and strain on the oncology workforce, will continue to motivate patients, healthcare providers policy makers better understand existing growing challenges of access chemotherapy. Administrative data, SEER-Medicare data particular, have been used assess patterns utilization because rich information regarding their treatments, providers. To create measures geographic chemotherapy, patients oncologists must first be identified....