A5071301224- Infant Nutrition and Health
- Neonatal Respiratory Health Research
- Prenatal Screening and Diagnostics
- Salivary Gland Disorders and Functions
- Genomics and Rare Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and preeclampsia studies
- Infant Health and Development
- Birth, Development, and Health
- Oral microbiology and periodontitis research
- Neonatal and fetal brain pathology
- Health and Medical Research Impacts
- Pharmaceutical studies and practices
- Fetal and Pediatric Neurological Disorders
- Infant Development and Preterm Care
- Neuroscience of respiration and sleep
- Breastfeeding Practices and Influences
- Biomedical Ethics and Regulation
- Prenatal Substance Exposure Effects
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Ethics in Clinical Research
- Neonatal and Maternal Infections
- Renal and related cancers
- Pharmaceutical Economics and Policy
Women & Infants Hospital of Rhode Island
2021-2025
Providence College
2021-2025
Brown University
2021-2025
Evans Analytical Group (United States)
2025
Tufts Medical Center
2015-2024
Tufts Children's Hospital
2010-2023
Ibero American University
2015-2023
Semmelweis University
2022
Duke University
2022
Infant
2012-2021
Importance Genomic testing in infancy guides medical decisions and can improve health outcomes. However, it is unclear whether genomic sequencing or a targeted neonatal gene-sequencing test provides comparable molecular diagnostic yields times to return of results. Objective To compare outcomes with those test. Design, Setting, Participants The Medicine for Ill Neonates Infants (GEMINI) study was prospective, comparative, multicenter 400 hospitalized infants younger than 1 year age (proband)...
<h3>Importance</h3> A targeted genomic sequencing platform focused on diseases presenting in the first year of life may minimize financial and ethical challenges associated with rapid whole-genomic sequencing. <h3>Objective</h3> To report interim variants interpretations an ongoing study comparing a novel composed 1722 actionable genes targeting disorders infancy. <h3>Design, Setting, Participants</h3> The Genomic Medicine Ill Neonates Infants (GEMINI) is prospective, multicenter clinical...
We aimed to detect C-reactive protein (CRP) in neonatal saliva and evaluate its diagnostic utility.Salivary serum samples (n = 89) were collected from 40 neonates. Salivary CRP levels determined using an enzyme-linked immunosorbent assay; was measured per hospital protocol. Correlation coefficients with 95% confidence intervals robust linear regression association while receiver-operator characteristic curves described the accuracy of salivary discriminating abnormal thresholds ≥10 5 mg/L....
Journal Article From the Perspective of Child: Ethical Considerations for Implementation Genomic Sequencing into Neonatal and Pediatric Care Get access Jill L Maron, Maron Department Pediatrics, Pediatrician-in-Chief, Women & Infants Hospital Rhode Island, Providence, RI, United States Address correspondence to this author at: 101 Dudley Street RI 02905, States. E-mail [email protected]. Search other works by on: Oxford Academic Google Scholar Sharon F Terry President CEO, Genetic Alliance,...
Sepsis is a life-threatening condition that affects millions of newborns every year. Current diagnostic practices require painful, often repetitive, blood collections to isolate and culture the causative microorganism. Definitive return results can take up 5 days, exposing potentially unnecessary antibiotics. Developing more rapid, non-invasive assessment infectious status based upon host immune response provides an alternative approach infection screening. However, additional collection for...
The lack of physical contact during therapeutic hypothermia (TH) is challenging for parents newborns with hypoxic ischemic encephalopathy. Holding often avoided due to concerns effects on infant temperature and dislodging equipment. We assessed the effect holding TH maternal salivary cortisol levels vital signs. Prospective crossover study infants randomized a 30-minute session day-2 versus day-3 TH. "No-holding" occurred alternate day at same time. Pre- post-holding were compared between...
The discovery of fetal mRNA transcripts in the maternal circulation holds great promise for noninvasive prenatal diagnosis. To identify potential biomarkers, we studied whole blood and plasma gene that were common to 9 term pregnant women their newborns but absent or reduced mothers postpartum. RNA was isolated from peripheral umbilical hybridized expression arrays. Gene expression, paired Student's t test, pathway analyses performed. In blood, 157 met statistical significance. These...
Olfactory maturation is essential for successful oral feeding. Previous studies have suggested that olfactory stimulation with maternal breast milk may expedite feeding skills in the premature infant; however, optimal developmental window to utilize this intervention and sex-specific responses stimuli are largely unknown.
There is an important need to develop noninvasive biomarkers detect disease in premature neonates. Our objective was determine if salivary genomic analysis provides novel information about neonatal expression of developmental genes.Saliva (50-200 microL) prospectively collected from 5 infants at time points: before, starting, and advancing enteral nutrition; the introduction oral feeds; advanced feeds. Salivary RNA extracted, amplified, hybridized onto whole-genomic...
<i>Background:</i> Gene expression profiling of the salivary supernatant is emerging as a new and important source real-time, systemic, biological information. However, existing technologies prevent RNA extraction small quantities found in neonatal supernatant. <i>Objective:</i> The aim this study was to develop techniques enhance cell-free from <i>Methods:</i> Two saliva samples (10–100 µl) were serially collected newborns (36–41 weeks’ gestation) (n =...
Background The current practice in newborn medicine is to subjectively assess when a premature infant ready feed by mouth. When the assessment inaccurate, resulting feeding morbidities may be significant, long-term health consequences and millions of care dollars annually. We hypothesized that developmental maturation hypothalamic regulation behavior predictor successful oral infant. To test this hypothesis, we analyzed gene expression neuropeptide Y2 receptor (NPY2R), known regulator...
Abstract: Oral feeding competency is a milestone most infants must achieve prior to discharge. It developmentally complex task that requires integration of multiple sensory inputs, central nervous system maturation, motor coordination, and respiratory stability. While ensuring safety during oral important reduce morbidities, we optimize developmental windows expedite maturation. Currently, many the assessments therapies related skills focus solely on nutritive non-nutritive sucking. Yet,...