A5031671404- Health and Medical Research Impacts
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Evolution and Paleontology Studies
- scientometrics and bibliometrics research
- Cytomegalovirus and herpesvirus research
- Global Health and Surgery
- Science, Research, and Medicine
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Telemedicine and Telehealth Implementation
- Mobile Health and mHealth Applications
- SARS-CoV-2 and COVID-19 Research
- Antibiotic Use and Resistance
- Biotechnology and Related Fields
- Social Media in Health Education
- Interdisciplinary Research and Collaboration
- COVID-19 epidemiological studies
- Herpesvirus Infections and Treatments
- Historical Medical Research and Treatments
- Mental Health and Patient Involvement
- Community Development and Social Impact
- Artificial Intelligence in Healthcare and Education
- Data-Driven Disease Surveillance
- COVID-19 Digital Contact Tracing
University of Copenhagen
2018-2025
Centre of Excellence for Health, Immunity and Infections
2018-2020
Rigshospitalet
2018-2020
Copenhagen University Hospital
2019
Abstract Digital technologies are rapidly being integrated into a wide range of health fields. This new domain, often termed ‘digital health’, has the potential to significantly improve healthcare outcomes and global equity more broadly. However, its effective implementation responsible use contingent on building workforce with sufficient level knowledge skills effectively navigate digital transformations in health. More specifically, next generation professionals—namely youth—must be...
As whole genomes become widely available, maximum likelihood and Bayesian phylogenetic methods are demonstrating their limits in meeting the escalating computational demands. Conversely, distance-based efficient, but rarely favoured due to inferior performance. Here, we extend phylogenetics using an entropy-based of evolution among pairs taxa, allowing for fast inference genome-scale datasets. We provide evidence a close link between criteria used distance Felsenstein's likelihood, such that...
Persistent SARS-CoV-2 infections have been hypothesized to play a key role in the emergence of variants concern. However, factors determining which individuals are at risk and their viral molecular signatures during infection remain poorly understood. Using extensive COVID-19 surveillance database Denmark, comprising over 700,000 genomes, we identified 303 persistent and, critically, linked them health sociodemographic data. Our analysis confirms hypothesis that immunocompromised highest...
Binary phylogenetic trees inferred from biological data are central to understanding the shared history among evolutionary units. However, inferring placement of latent nodes in a tree is computationally expensive. State-of-the-art methods rely on carefully designed heuristics for search, using different structures easy manipulation (e.g., classes object-oriented programming languages) and readable representation Newick-format strings). Here, we present Phylo2Vec, parsimonious encoding that...
Rates and risk factors for cytomegalovirus (CMV) prophylaxis breakthrough discontinuation were investigated, given uncertainty regarding optimal dosing CMV primary (val)ganciclovir after solid organ transplantation (SOT).Recipients transplanted from 2012 to 2016 initiated on followed until 90 days post-transplantation. A score each patient per day was calculated during the follow-up time (FUT; of 100 corresponding manufacturers' recommended dose a estimated glomerular filtration rate...
Transplant recipients are an immunologically vulnerable patient group and at elevated risk of Clostridioides difficile infection (CDI) compared with other hospitalized populations. However, factors for CDI post-transplant not fully understood.Adults undergoing solid organ (SOT) hematopoietic stem cell transplant (HSCT) from January 2010 to February 2017 Rigshospitalet, University Copenhagen, Denmark, were retrospectively included. Using nationwide data capture all cases, the incidence...
To the Editor: The potential of digital technologies in clinical settings is enormous. However, to take full advantage these technologies, medical students need have a basic understanding how and why they work, as well their pitfalls. Unfortunately, rate implementation far exceeding increasing health literacy. Although some statistics, epidemiology, informatics courses are offered at schools, students, we do not receive training fields, such artificial intelligence (AI), biohacking, or big...
Abstract Birth–death models are stochastic processes describing speciation and extinction through time across taxa widely used in biology for inference of evolutionary timescales. Previous research has highlighted how the expected trees under constant-rate birth–death (crBD) model tend to differ from empirical trees, example, with respect amount phylogenetic imbalance. However, our understanding between crBD signal data remains incomplete. In this Point View, we aim expose degree which...
Vast amounts of pathogen genomic, demographic and spatial data are transforming our understanding SARS-CoV-2 emergence spread. We examined the drivers molecular evolution spread 291,791 genomes from Denmark in 2021. With a sequencing rate consistently exceeding 60%, up to 80% PCR-positive samples between March November, viral genome set is broadly whole-epidemic representative. identify consistent rise diversity over time, with notable spikes upon importation novel variants (e.g., Delta...
Abstract The implementation of new antimicrobial resistance stewardship programs is crucial in optimizing antibiotic use. However, prescription choices can be difficult during empiric therapy; clinicians must balance the survival benefits broader spectrum antibiotics with associated increases resistance. aim this study was to evaluate overall feasibility switching narrow treatment E. coli bacteraemia by quantifying changes rates, usage, and mortality using a deterministic state-transition...
Mosquito ecology and behavior malaria parasite development display marked sensitivity to weather, in particular temperature precipitation. Therefore, climate change is expected profoundly affect epidemiology its transmission, spatiotemporal distribution consequent disease burden. However, transmission also complicated by other factors (e.g. urbanization, socioeconomic development, genetics, drug resistance) which together constitute a highly complex, dynamical system, where the influence of...
Poultry farming is threatened by regular outbreaks of Escherichia coli (E. coli) that lead to significant economic losses and public health risks. However, traditional surveillance methods often lack sensitivity scalability. Early detection infected poultry using minimally invasive thus essential for preventing epidemics. To end, we leverage recent advancements in computer vision, employing deep learning-based tracking detect behavioral changes associated with E. infection a case-control...
Abstract Background Cytomegalovirus (CMV) is a serious complication following Hematopoietic Stem Cell Transplant (HSCT) and can lead to organ disease mortality. This study aimed investigate the association between absolute lymphocyte count (ALC) CMV determine whether ALC could help identify those at an increased risk of infection recurrence Methods Adults undergoing HSCT 2011 2016 Rigshospitalet, Denmark were included. Cox proportional hazards models investigated factors, including ALC, for...
Abstract Evidence suggests that a certain degree of clustering and narrowing research trajectories is occurring, both on the individual disease levels. Mechanisms this process include biases in funding, lack coordination among funders, significant funding role for-profit actors, lobbying by special interest groups. The implication fewer individuals might control direction diseases could garner disproportionate amount attention resources, which be an epistemic threat to medical progress. In...
Abstract Background Solid organ transplant (SOT) recipients are at a high risk of developing cytomegalovirus (CMV) post-transplant (tx) with many experiencing recurrence shortly after clearing the first episode. We aimed to identify factors associated CMV infection and recurrence. Methods SOT (≥ 18 years) transplanted between 2011-2016 were investigated for within 1 year from baseline recurrent 6 months stopping treatment using cumulative incidence curves Cox proportional hazards models....