A5043519707- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- COVID-19 and healthcare impacts
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Hip and Femur Fractures
- Biliary and Gastrointestinal Fistulas
- Trauma and Emergency Care Studies
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Gastrointestinal Tumor Research and Treatment
- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Abdominal Surgery and Complications
- Renal and related cancers
- Gastroesophageal reflux and treatments
- Emergency and Acute Care Studies
Eastern Health
2014-2025
Sir Charles Gairdner Hospital
2024
Box Hill Hospital
2008-2024
St Vincent's Hospital
2009-2024
The University of Melbourne
2018-2024
Monash University
2014-2022
University Hospital of Wales
2022
Cardiff University
2022
St. James's Hospital
2015
21st Century Oncology (United States)
2010-2014
In patients with resectable colorectal liver metastases (CRLM), the role of pre- and postoperative systemic therapy continues to be debated. Previous studies have shown that circulating tumor DNA (ctDNA) analysis, as a marker minimal residual disease, is powerful prognostic factor in nonmetastatic cancer (CRC). Serial analysis ctDNA CRLM could inform optimal use perioperative chemotherapy. Here, we performed validation study confirm impact observed previous discovery study.We prospectively...
ABSTRACT Choledochoduodenal fistula secondary to pancreatic lymphoma is a rare phenomenon, reflecting the complex relationship between lymphoproliferative disorders and gastrointestinal complications. Fistula formation should be suspected in patients with persistent liver function abnormalities history of treated hematological malignancies.
Adrian Fox and Naomi Elliott report on nurses' experience of using the tool problems they encountered
Background & AimsLiver sinusoidal endothelial cells (LSECs) are important in liver development, regeneration and pathophysiology, but the differentiation process underlying their tissue-specific phenotype is poorly understood difficult to study as primary human scarce. The aim of this was use induced pluripotent stem cell (hiPSC)-derived LSEC-like investigate LSECs.MethodshiPSC-derived were transplanted into livers Fah−/−/Rag2−/−/Il2rg−/− mice assessed over a 12-week period. Lineage tracing,...
•Real-world outcomes in BR pancreatic cancer.•Neoadjuvant FOLFIRINOX associated with improved survival versus upfront surgery.•Pooled NATs not outcomes.•No benefit from neoadjuvant gemcitabine and nab-paclitaxel surgery. BackgroundThis study explores the potential benefits of chemotherapy borderline resectable (BR) adenocarcinoma. Despite treatment (NAT) increasingly being utilised, uncertainty remains as to optimal approach.Patients methodsThis assessed clinical for 218 consecutive patients...
11150 Background: With around 90% KRASmutation (mt) frequency, pancreatic ductal adenocarcinoma (PDAC) is considered the most RAS-addicted cancer. Despite guideline recommendations, genomic testing not routine in all PDAC patients (pts) Australia, due to unproven clinical impact. As more novel KRAS-direct therapeutics enter trials, understanding real-world frequency of individual mutations and prognostic significance, facilitating trial recruitment are important goals, which can be supported...
Combination gemcitabine and nab-paclitaxel (Gem-Nab-P) is a common regimen used to treat metastatic pancreatic ductal adenocarcinoma (PDAC). Toxicity from this associated with significant morbidity. Currently, Gem-Nab-P dosed using estimated body surface area, derived height weight. This study investigates whether skeletal muscle assessment could be useful tool in the dosing of PDAC. included 52 patients who had received first-line treatment for Demographic chemotherapy information was...
Abstract Background The aim of this study was to evaluate the role magnetic resonance cholangiopancreatography in cases suspected choledocholithiasis. Methods Suitable candidates were recruited from a database all consecutive patients who underwent between M arch 2009 and D ecember 2012. Patients stratified into low, medium high risk for choledocholithiasis by assessing clinical symptoms, liver function tests ultrasonography. True negatives false positives calculated based on endoscopic...
Intraductal papillary mucinous neoplasms (IPMN) are cystic of the pancreatic ductal system. These incidental lesions increasingly found on radiological imaging and screened for malignant transformation. The Fukuoka consensus guidelines recommend screening with computed tomography, magnetic resonance or endoscopic ultrasound. Branch duct IPMN (BD-IPMN) have significantly lower malignancy mortality rates compared to main IPMN. Our aim was assess cost-effectiveness guideline's recommendations...
Sclerosing mesenteritis is associated with a spectrum of diseases which include mesenteric lipodystrophy and panniculitis. This inflammatory fibrosing disorder can affect the small large bowel wall vessels by exerting mass effect. The following case highlights difficulties diagnosing managing this unusual disease. A 64-year-old man presented acute central abdominal pain, radiating to his back, profuse vomiting. He was diagnosed clinically obstruction. had an episode obstruction 6 years...
Background Extended venothromboprophylaxis (eVTP) after abdominal surgery for hepatobiliary (HPB) and upper gastrointestinal (UGI) malignancies is recommended. Safety, efficacy compliance within this group of surgical patients are not well described. The primary aim was to assess safety post‐operative administration eVTP with low molecular weight heparin. Secondary barriers treatment monitor the rate venous thromboembolism. Methods A prospective observational cohort study undergoing HPB or...
Abstract Epithelioid hepatic angiomyolipoma (Epi‐HAML) is a rare tumor frequently misdiagnosed as hepatocellular carcinoma (HCC). Unlike conventional (AML), Epi‐HAML contains minimal amount of adipose tissue, which radiological distinguishing feature between AML and HCC. Two patients were referred for management incidentally found lesions confirmed to be on post‐resection tissue analysis. CT MRI findings suggestive Contrast‐enhanced ultrasound demonstrated intratumoral shunting, feeding...
Abstract Purpose Hounsfield unit density of biliary fluid on CT may be a useful clinical marker that has not been described in the literature. This method used to differentiate pyonephrosis from hydronephrosis obstructed collecting systems kidney. We aimed create user‐friendly technique measure distal bile duct using CT. The cases with proven choledocholithiasis at ERCP were compared those control group (no pathology). Methods A total 106 patients and 50 analysed. was calculated 4‐point max...
Background: There is currently a shortage of surgeons working in rural Australia. This may be due to partner dissatisfaction with placements during training. Methods: A questionnaire encompassing logistic, financial and emotional aspects peripheral was distributed trainees their partners. similar also 25 surgical consultants. Results: Seventy‐four per cent were either married or long‐term relationships. further 24% had children. The average number residential moves year training 0.74....
622 Background: Selective internal radiation therapy (SIRT) using Yttrium-90 containing microspheres has established benefit for a number of cancers but there is limited data available on the utility SIRT treatment metastatic pancreatic ductal adenocarcinoma (PDAC). Methods: In this retrospective audit we identified 32 patients who received PDAC in 2 centres. All combination with chemotherapy. Data was analysed from electronic medical records. Results: Thirty two had were identified....