A5078131746- 3D Printing in Biomedical Research
- Hepatitis C virus research
- Clinical Nutrition and Gastroenterology
- Neuroscience and Neural Engineering
- Hepatitis B Virus Studies
- Hydrogels: synthesis, properties, applications
- Gastrointestinal motility and disorders
- Radiation Therapy and Dosimetry
- Pregnancy and Medication Impact
- Biomedical and Engineering Education
- Pharmacological Effects and Toxicity Studies
- Reproductive Health and Contraception
- Advanced Radiotherapy Techniques
- Genetics, Bioinformatics, and Biomedical Research
- Food Chemistry and Fat Analysis
- Pharmaceutical studies and practices
- Effects of Radiation Exposure
- Advanced Sensor and Energy Harvesting Materials
- Biochemical and Structural Characterization
- Proteins in Food Systems
- Gastrointestinal Bleeding Diagnosis and Treatment
- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Lipid Membrane Structure and Behavior
Massachusetts Institute of Technology
2018-2023
University of Massachusetts Chan Medical School
2019
Light-triggerable hydrogels enable on-demand degradation of gastrointestinal-resident devices, reducing the need for invasive interventions.
Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident devices require invasive procedures for as well a specialized receiver communication. Here, gastric electronic (GRE) system that leverages anatomical space offered by environment to enable residence an orally delivered platform such within is presented. The GRE capable directly interfacing with portable consumer personal through...
Administering medicines to 0- 5-year-old children in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on-field reconstitution, and are thermostable, cheap, versatile, taste masking. We present strategy stands solve this multifaceted problem. As many drugs lack adequate water solubility, our formulations used oils, whose textures could be modified with gelling agents form "oleogels." In clinical study, we showed the oleogels can formulated as fluid...
An oral dosage form that resides in the stomach releases contraceptive levonorgestrel over 1 month pigs.
A retrievable device, compatible with nasogastric tube administration, releases grams of drug over weeks while residing in the stomach.
Significance Direct-acting antiviral (DAA) therapy is highly effective against hepatitis C virus (HCV). Despite this, the burden of chronic HCV remains high, particularly in populations for whom daily medications can be challenging. The generation long-acting modes DAA delivery could thus expand treatment. We have developed a system (LA-DAAS) that support multigram-level drug depots DAAs and provide controlled release those drugs over course weeks. demonstrate initial safety efficacy LA-DAAS...
Triggerable coatings, such as pH-responsive polymethacrylate copolymers, can be used to protect the active pharmaceutical ingredients contained within oral solid dosage forms from acidic gastric environment and facilitate drug delivery directly intestine. However, gastrointestinal pH highly variable, which reduce efficiency when using technologies. We hypothesized that biomaterials susceptible proteolysis could in combination with other triggerable polymers develop novel enteric coatings....
Abstract Gastric resident dosage forms have been used successfully in farm animals for the delivery of a variety drugs helping address challenge extended dosing. Despite these advances, there remains significant across range species with large variation body size. To this, we investigate scalable gastric platform capable prolonged retention. We prototypes dimensions consistent administration and retention stomachs two (rabbit pig). sustained our form platform, pigs show capacity to modulate...
Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce dose critical GI structures including rectum and oral mucosa, 3D-printed radioprotective devices composed high-Z materials are generated from patient CT scans. In a proctitis rat model, significant reduction in crypt is demonstrated with device compared without (p < 0.0087). Optimal placement for attenuation further confirmed swine model....
Technological breakthroughs in the past two decades have ushered a new era of biomedical research, turning it into an information-rich and technology-driven science. This scientific revolution, though evident to research community, remains opaque nonacademic audiences. Such knowledge gaps are likely persist without revised strategies for science education public outreach. To address this challenge, we developed unique outreach program actively engage over 100 high-school students...