A5069256055- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- 3D Printing in Biomedical Research
- Virus-based gene therapy research
- Advanced Sensor and Energy Harvesting Materials
- DNA and Nucleic Acid Chemistry
- Clinical Nutrition and Gastroenterology
- Chronic Myeloid Leukemia Treatments
- Injection Molding Process and Properties
- Viral gastroenteritis research and epidemiology
- Bone Tissue Engineering Materials
- Food Chemistry and Fat Analysis
- Analytical Methods in Pharmaceuticals
- Hydrogels: synthesis, properties, applications
- Proteins in Food Systems
- Diet and metabolism studies
- Pregnancy and Medication Impact
- Advanced Materials and Mechanics
- Drug Transport and Resistance Mechanisms
- Neuroscience and Neural Engineering
- Pharmacological Effects and Toxicity Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Reproductive Health and Contraception
University of Connecticut
2020-2024
Massachusetts Institute of Technology
2017-2022
Novartis-MIT Center for Continuous Manufacturing
2017
Long-term implantation of biomedical electronics into the human body enables advanced diagnostic and therapeutic functionalities. However, most long-term resident devices require invasive procedures for as well a specialized receiver communication. Here, gastric electronic (GRE) system that leverages anatomical space offered by environment to enable residence an orally delivered platform such within is presented. The GRE capable directly interfacing with portable consumer personal through...
Administering medicines to 0- 5-year-old children in a resource-limited environment requires dosage forms that circumvent swallowing solids, avoid on-field reconstitution, and are thermostable, cheap, versatile, taste masking. We present strategy stands solve this multifaceted problem. As many drugs lack adequate water solubility, our formulations used oils, whose textures could be modified with gelling agents form "oleogels." In clinical study, we showed the oleogels can formulated as fluid...
Temperature-responsive, reconfigurable metamaterials actuated by ingestion of warm water can be applied to the upper gastrointestinal tract.
An oral dosage form that resides in the stomach releases contraceptive levonorgestrel over 1 month pigs.
Many diseases, especially cancer, are caused by the abnormal expression of non-coding microRNAs (miRNAs), which regulate gene expression, leading to development miRNA-based therapeutics. Synthetic miRNA inhibitors have shown promising efficacy in blocking activity aberrant miRNAs that upregulated disease-specific pathologies. On other hand, aid preventing certain diseases and reduced disease state need different strategies. To tackle this, mimics, mimic endogenous miRNAs, can be delivered...
Abstract Peptide nucleic acids (PNAs) are used/applied in various studies to target genomic DNA and RNA modulate gene expression. Non‐specific targeting rapid elimination always remain a challenge for PNA‐based applications. Here, the synthesis, characterization, vitro vivo study of di lactobionic acid (diLBA) tris N‐acetyl galactosamine (tGalNAc) conjugated PNAs liver‐targeted delivery reported. For proof concept, diLBA, tGalNAc (anti‐miR‐122 PNAs) were synthesized microRNA‐122 (miR‐122)...
Cationic polymeric nanoformulations have been explored to increase the transfection efficiency of small molecules and nucleic acid-based drugs. However, an excessive positive charge density often leads severe cell tissue-based toxicity that restricts clinical translation cationic nanoformulations. Herein, we investigate a series poly(lactic-
Abstract Gastric resident dosage forms have been used successfully in farm animals for the delivery of a variety drugs helping address challenge extended dosing. Despite these advances, there remains significant across range species with large variation body size. To this, we investigate scalable gastric platform capable prolonged retention. We prototypes dimensions consistent administration and retention stomachs two (rabbit pig). sustained our form platform, pigs show capacity to modulate...
The plasma membrane-bound protein, multi-drug resistance-associated protein 4 (