A5078584533- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Dermatology and Skin Diseases
- Contact Dermatitis and Allergies
- Lipid Membrane Structure and Behavior
- Ocular Surface and Contact Lens
- Toxin Mechanisms and Immunotoxins
- Advanced Sensor and Energy Harvesting Materials
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Photodynamic Therapy Research Studies
- Transgenic Plants and Applications
- Optical Coherence Tomography Applications
- CRISPR and Genetic Engineering
- Advanced Materials and Mechanics
- Coffee research and impacts
- 3D Printing in Biomedical Research
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Pharmaceutical studies and practices
- Pancreatic function and diabetes
Chiesi (United States)
2023
Massachusetts Institute of Technology
2017-2021
Leo Pharma (Denmark)
2021
Queen's University Belfast
2012-2017
Delivering fragile drugs to the gut Oral delivery is simplest and least invasive way deliver many pharmaceuticals, but medications, including insulin, cannot survive passage through stomach or gastrointestinal tract. Abramson et al. developed an ingestible vehicle that could self-reorient from any starting position so as attach gastric wall. Encapsulation of a spring in sugar casing allowed for triggered actuation biomolecules. The approach successfully provided active insulin pigs. Science...
We describe, for the first time, hydrogel-forming microneedle arrays prepared from "super swelling" polymeric compositions. produced a formulation with enhanced swelling capabilities aqueous blends containing 20% w/w Gantrez S-97, 7.5% PEG 10,000 and 3% Na2CO3 utilised drug reservoir of lyophilised wafer-like design. These microneedle-lyophilised wafer compositions were robust effectively penetrated skin, extensively, but being removed intact. In in vitro delivery experiments across excised...
We describe, for the first time use of hydrogel-forming microneedle (MN) arrays minimally-invasive extraction and quantification drug substances glucose from skin in vitro vivo. MN prepared aqueous blends hydrolysed poly(methyl-vinylether-co-maleic anhydride) (11.1% w/w) poly(ethyleneglycol) 10,000 daltons (5.6% crosslinked by esterification swelled upon insertion uptake fluid. Post-removal, theophylline caffeine were extracted determined using HPLC, with quantified a proprietary kit. In...
Transdermal drug delivery is an attractive route of administration; however, there are relatively few marketed transdermal products. To increase across the skin, strategies to enhance skin permeability widely investigated, with microneedles demonstrating particular promise. Hydrogel-forming inserted into and following dissolution a loaded reservoir movement through created channels, microneedle array removed intact, can then be readily safely discarded. This study presents formulation...
Microneedles with high drug-loaded tips allow fast and painless delivery of biologics into the buccal mucosa.
We describe, for the first time, hydrogel-forming microneedle (s) (MN) arrays minimally-invasive extraction and quantification of lithium in vitro vivo. MN arrays, prepared from aqueous blends hydrolysed poly(methyl-vinylether-co-maleic anhydride) crosslinked by poly(ethyleneglycol), imbibed interstitial fluid (ISF) upon skin insertion. Such were always removed intact. In vitro, mean detected concentrations showed no significant difference following 30min application to excised neonatal...
Temperature-responsive, reconfigurable metamaterials actuated by ingestion of warm water can be applied to the upper gastrointestinal tract.
Photodynamic therapy involves delivery of a photosensitising drug that is activated by light specific wavelength, resulting in generation highly reactive radicals. This species can cause destruction targeted cells. Application this process for treatment microbial infections has been termed “photodynamic antimicrobial chemotherapy” (PACT). In the chronic wounds, agents often impeded presence thick hyperkeratotic/necrotic tissue layer, reducing their therapeutic efficacy. Microneedles (MNs)...