A5055864622- Spectroscopy and Chemometric Analyses
- Advanced Chemical Physics Studies
- Chemical Reactions and Mechanisms
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Spectroscopy and Laser Applications
- Inorganic and Organometallic Chemistry
- Chemical Synthesis and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Enzyme Catalysis and Immobilization
- Thermochemical Biomass Conversion Processes
- Crystallization and Solubility Studies
- Advanced Drug Delivery Systems
- Click Chemistry and Applications
- X-ray Diffraction in Crystallography
- Polymer Synthesis and Characterization
- Lignin and Wood Chemistry
- 3D Printing in Biomedical Research
- Atmospheric Ozone and Climate
- Atmospheric chemistry and aerosols
- Catalytic Processes in Materials Science
- Synthesis and Properties of Aromatic Compounds
- Organic Chemistry Cycloaddition Reactions
- Catalysis and Oxidation Reactions
- Zeolite Catalysis and Synthesis
Novo Nordisk (Denmark)
2012-2022
Danish Technological Institute
2021
Novo Nordisk (United Kingdom)
2017
University of Colorado Boulder
2001-2003
National Renewable Energy Laboratory
1998-2001
Colorado School of Mines
1998-2001
Delivering fragile drugs to the gut Oral delivery is simplest and least invasive way deliver many pharmaceuticals, but medications, including insulin, cannot survive passage through stomach or gastrointestinal tract. Abramson et al. developed an ingestible vehicle that could self-reorient from any starting position so as attach gastric wall. Encapsulation of a spring in sugar casing allowed for triggered actuation biomolecules. The approach successfully provided active insulin pigs. Science...
Insulin degludec, an engineered acylated insulin, was recently reported to form a soluble depot after subcutaneous injection with subsequent slow release of insulin and ultralong glucose-lowering effect in excess 40 h humans. We describe the structure, ligand binding properties, self-assemblies degludec using orthogonal structural methods. The protein fold adopted by is very similar that human insulin. Hexamers R(6) state those are observed for presence zinc resorcinol. However, under...
We have measured the infrared absorption spectrum of C(6)H(5), /X (2)A(1), in an Ar matrix at 10 K. The experimental frequencies (cm(-)(1)) and polarizations follow. a(1) modes: 3086, 3072, 3037, 1581, 1441, 1154, 1027, 997, 976, 605; b(1) 972, 874, 706, 657, 416; b(2) 3071, 3060, 1624, 1432, 1321, 1283, 1159, 1063, 587. Three different methods been used for production phenyl radicals. Infrared spectra five deuterated isotopomers, C(6)D(5), p-C(6)H(4)D, p-C(6)HD(4), o-C(6)H(4)D, m-C(6)H(4)D,...
We have incorporated a pulsed, hyperthermal nozzle with cryostat to study the matrix-isolated infrared spectroscopy of organic radicals. The radicals are produced by pyrolysis in heated, narrow-bore (1-mm-diam) SiC tube and then expanded into vacuum chamber. combination high temperature (up 1800 K) near-sonic flow velocities (on order 104 cm s−1) through length 2 allows for yield (approximately 1013 pulse−1) low residence time 10 μs) nozzle. used this nozzle/matrix isolation experiment...
Microwave-assisted gas-phase conversion on structured catalysts is emerging as a promising process intensification technology in the field of heterogeneous catalysis. The combination selective heating and catalytic materials induces temperature difference between heated sample surrounding void regions to avoid non-selective reactions. This operational principle allowed inhibiting thermal cracking alkane dehydrogenation processes well retarding catalyst deactivation by coking methane...
Results of an experimental and theoretical study cyclopenta-2,4-dienylideneketene ( 3 ), a highly unstable reactive intermediate, are reported. The ketene was prepared, under matrix isolation conditions at 4.2 or 10 K, by laser photocarbonylation 1,2-didehydrobenzene 1 ) photogenerated earlier from phthalic anhydride 2 ). FTIR polarization measurements performed on partially photooriented samples immobilized in solid neon argon provide infrared transition moment directions for most the...
We report the results of noise source investigations and stability tests in both dual- single-beam Fourier-transform near-infrared operation. The sources are divided into two parts: intrinsic extrinsic. sources, which include detector system noise, common for modes extrinsic variations ambient conditions (room temperature, atmospheric gaseous components, scintillations), shown to be smaller dual-beam operation than by a factor 2-10. based on interferograms measured specified time intervals....
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