A5049968390- Advanced Drug Delivery Systems
- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Head and Neck Surgical Oncology
- interferon and immune responses
- Antimicrobial Peptides and Activities
- Radiation Therapy and Dosimetry
- RNA Interference and Gene Delivery
- Reproductive tract infections research
- Virus-based gene therapy research
- Chemical Synthesis and Analysis
- Pancreatic function and diabetes
- Click Chemistry and Applications
- PARP inhibition in cancer therapy
- 3D Printing in Biomedical Research
- Monoclonal and Polyclonal Antibodies Research
Yale University
2021-2024
University of New Haven
2021
Massachusetts Institute of Technology
2019
Delivering fragile drugs to the gut Oral delivery is simplest and least invasive way deliver many pharmaceuticals, but medications, including insulin, cannot survive passage through stomach or gastrointestinal tract. Abramson et al. developed an ingestible vehicle that could self-reorient from any starting position so as attach gastric wall. Encapsulation of a spring in sugar casing allowed for triggered actuation biomolecules. The approach successfully provided active insulin pigs. Science...
Significance Functionalization of proteins and biopolymers with chemical modifications can be utilized to alter their biophysical properties. In contrast traditional functionalization strategies, the use nonstandard amino acids enables precise positioning functional groups. Here, we report that multisite conjugation fatty acids, at sites harboring genetically encoded bioorthogonal handles, employed tune half-life in a mouse model. This programmable approach could offer technical foundation...
The morbidity associated with pediatric medulloblastoma, in particular patients who develop leptomeningeal metastases, remains high the absence of effective therapies. Administration substances directly into cerebrospinal fluid (CSF) is one approach to circumvent blood-brain barrier and focus delivery drugs site tumor. However, rates CSF turnover prevent adequate drug accumulation lead rapid systemic clearance toxicity. Here, we show that PLA-HPG nanoparticles, made a single-emulsion,...
Abstract Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of microbicides, but achieving long‐term delivery to canal has been a significant challenge. To advance understanding retention and biodistribution, we describe method noninvasive imaging with 89 Zr‐labeled bioadhesive nanoparticles (BNPs) in non‐human primates. We additionally examined safety repeated BNP application. BNPs administered vaginally cynomolgus monkeys were still detected after 24 h (1.7%...
Abstract Targeting tumors of the central nervous system remains challenging given physiological barriers preventing delivery therapeutics across blood brain barrier (BBB). This is particularly true for nucleic acids, which degrade rapidly in serum and often fail to penetrate cells even with proper formulation into AAVs or LNPs. To overcome these barriers, many current efforts rely on invasive methods delivery, including intrathecal intraparenchymal injection. Here we report studies...