A5047425905- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- CRISPR and Genetic Engineering
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Dental Erosion and Treatment
- Extracellular vesicles in disease
- Conservation Techniques and Studies
- Fluoride Effects and Removal
- Music Technology and Sound Studies
- Aesthetic Perception and Analysis
- Digital Media Forensic Detection
- Cystic Fibrosis Research Advances
- Spam and Phishing Detection
- Hate Speech and Cyberbullying Detection
- Advanced Authentication Protocols Security
- Nanopore and Nanochannel Transport Studies
- Digital Imaging for Blood Diseases
- Dental Health and Care Utilization
- Text and Document Classification Technologies
- Laser-Ablation Synthesis of Nanoparticles
- Tattoo and Body Piercing Complications
- Virology and Viral Diseases
- COVID-19 Clinical Research Studies
University of Saint Joseph
2021-2024
Graphic Era University
2023-2024
University Of Bristol Dental Hospital
2021-2024
University of Bristol
2021-2024
Yale University
2015-2024
King's College London
2021
King's College Hospital
2021
Delhi Technological University
2021
Wesleyan University
2020
Baylor College of Medicine
2020
MicroRNAs (miRs) are frequently overexpressed in human cancers. In particular, miR-210 is induced hypoxic cells and acts to orchestrate the adaptation of tumor hypoxia. Silencing oncogenic miRs such as may therefore offer a promising approach anticancer therapy. We have developed inhibition strategy based on new class conformationally preorganized antisense γ peptide nucleic acids (γPNAs) that possess vastly superior RNA-binding affinity, improved solubility, favorable biocompatibility. For...
Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. We sought to correct multiple organ dysfunction of F508del CF-causing mutation using systemic delivery peptide nucleic acid gene editing technology mediated biocompatible polymeric nanoparticles. confirmed phenotypic and genotypic modification vitro primary nasal epithelial cells from mice grown at air-liquid interface vivo following intravenous delivery. In treatment resulted a partial...
Peptide nucleic acids (PNAs) are synthetic acid analogs with a neutral N-(2-aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such as increased resistance to enzymatic degradation, ionic strength and stability over wide range of temperatures pH, low intrinsic electrostatic repulsion against complementary target oligonucleotides. PNA has been widely used an antisense oligonucleotide (ASO). Despite the favorable PNA, in comparison other ASO technologies, use for...
Gene regulatory networks (GRNs) describe the progression of transcriptional states that take a single-celled zygote to multicellular organism. It is well documented GRNs can evolve extensively through mutations cis-regulatory modules (CRMs). Transcription factor proteins bind these CRMs may also produce novelty. Coding changes are considered be rarer, however, because transcription factors multifunctional and hence more constrained in ways will not widespread detrimental effects. Recent...
Abstract Peptide nucleic acids (PNAs) are used/applied in various studies to target genomic DNA and RNA modulate gene expression. Non‐specific targeting rapid elimination always remain a challenge for PNA‐based applications. Here, the synthesis, characterization, vitro vivo study of di lactobionic acid (diLBA) tris N‐acetyl galactosamine (tGalNAc) conjugated PNAs liver‐targeted delivery reported. For proof concept, diLBA, tGalNAc (anti‐miR‐122 PNAs) were synthesized microRNA‐122 (miR‐122)...
We explore the potential of clamp-G nucleobase-modified peptide nucleic acids (cGPNAs) as microRNA and messenger RNA inhibitors. For proof concept, we target miR-155, which is upregulated in diffuse large B cell lymphoma. cGPNA shows significant downregulation miR-155 upregulation its downstream targets multiple lymphoma lines. Also, treatment vivo reduced tumor growth improved survival U2932 cell-derived xenograft mouse model. To assess broad application an antisense modality, also...
In utero gene editing has the potential to modify disease causing genes in multiple developing tissues before birth, possibly allowing for normal organ development, improvement, and conceivably, cure. cystic fibrosis (CF), a that arises from mutations transmembrane conductance regulator (
Abstract Molecular recognition of DNA quadruplex structures is envisioned to be a strategy for regulating gene expression at the transcriptional level and in situ analysis telomere structure function. The quadruplexes by peptide nucleic acid (PNA) oligomers presented here, with focus on comparing complementary, heteroduplex‐forming homologous, heteroquadruplex‐forming PNAs. Surface plasmon resonance optical spectroscopy experiments demonstrated that efficacy mode depended strongly target....
The guanine quadruplex (G-quadruplex) is a highly stable secondary structure that forms in G-rich repeats of DNA, which can interfere with DNA processes, including replication and transcription. We showed previously short guanine-rich peptide nucleic acids (PNAs) form hybrid quadruplexes DNA. hypothesized such structures would provide stronger block to polymerase extension on templates than native homoquadruplex because the greater thermodynamic stability PNA-DNA structures. To test this, we...
After Wesleyan University moved all classes online because of the global outbreak SARS-CoV-2, organic chemistry laboratory course adjusted its curriculum to fit circumstances. A symposium project with several components was introduced, allowing students develop their scientific writing, presentation, and critical thinking skills through assigned quiz, reading questions, discussion forum, article summary, oral presentation. paper published in ACS Omega about compounds garlic essential oil as...
This article examines the intersection of environmental justice and undergraduate chemistry education through a review existing publications that highlight successful strategies for educators interested in incorporating into their classrooms. It emphasizes key roles racial social Environmental Justice movement connection to shift toward diversity, equity, inclusion, respect today. Five co-operative educational are exemplified established project- problem-based learning examples, which...
The paper presents the design and implementation of an Ethernet-based intelligent automated system for conserving electrical energy using a INTEL GALILEO 2ND generation development board, which can be used in large organizations like University or office. proposed works on automation, so that devices switches remotely controlled monitored without any human intervention. It uses available infrastructure classroom includes surveillance camera Ethernet connectivity as to minimize cost criteria....
Virtual reality is a new and very revolutionizing concept its progress in the field of medical diagnosis taking this technology to another level. Simulators virtual give essential aptitude for preparing controlled domain, operating patients free pressure without supervision. These skills acquired can then be utilized training room. In applications better picture control, enhanced understanding, quantitative correlations, planning surgery. Not only has environment provided helped cope with...