Posttraumatic stress disorder (PTSD) is a trauma-induced mental characterized by fear extinction abnormalities, which involve biological dysfunctions among circuit areas in the brain. Oxytocin (OXT) neuropeptide that regulates sexual reproduction and social interaction has recently earned specific attention due to its role adjusting neurobiological behavioral correlates of PTSD; however, mechanism this achieved remains unclear. The present study aimed examine whether effects OXT on traumatic...

Traumatic experience may lead to various psychological sequelae including the unforgettable trauma-associated memory as seen in posttraumatic stress disorder (PTSD), with a mechanism of impaired fear extinction due biological imbalance among hypothalamic-pituitary-adrenal (HPA) axis and circuit areas such medial prefrontal cortex (mPFC), hippocampus, amygdala. Recently sociability PTSD patients received great attention involvement oxytocin (OXT) mediation is worth being investigated. This...

The heterogeneity of etiology may serve as a crucial factor in the challenges treatment, including low response rate and delay establishing therapeutic effect. In present study, we examined whether social experience since early life is one etiologies, with involvement 5-HT1A receptors, explored potentially action subchronic administration buspirone, partial agonist. Rats were isolation reared (IR) their weaning, depressive profile indexed by forced-swim test (FST) was adulthood. Nonspecific...

Abstract Aims To investigate the factors affecting quality of life among adults with comorbid serious mental illness and chronic diseases. Design Descriptive, cross‐sectional study design. Methods In total, 204 patients were recruited from two hospitals. Self‐reported data collected using Brief Psychiatric Rating Scale, Internalised Stigma Mental Illness, Patient Activation Measure brief version World Health Organization Quality Life Instrument. Data between July 2018 – January 2019. The...

Cold stress may produce hemodynamic perturbations but the underlying mechanisms are still not clear. Spectral analysis was used in this study to explore that sympathoadrenal activation could be involved of cooling. Conscious rats after treatment with a control vehicle (saline) compared withdrawal sympathetic influences by ganglion blocker hexamethonium (HEX) or chemical sympathectomy guanethidine (GUA) were challenged stressful cooling as acute immersing all four extremities ice water (4 ±...

Central 5-HT1A receptor is involved in the modulation of sensorimotor gating function. However, its precise role not clearly defined developmentally social deprived (isolation rearing, IR) rats featured with impaired ability. We therefore aimed to examine effects 5HT1A activation on acoustic startle response (ASR) and prepulse inhibition (PPI) IR a condition compromised presynaptic 5-HT functions.Social control (SOC) received an intracerebraoventricular (ICV) injection depletor, 5,7-DHT....

Prolonged paradoxical sleep deprivation (PSD) and cold stress (CS) are known to cause sympathoexcitation increase the risk of cardiovascular disease. The present study examined effect PSD with CS on hemodynamic perturbations by investigating blood pressure heart rate variability (BPV HRV) in conscious rats. Adult male Sprague-Dawley rats were divided into three groups (n = 10, each): normal (NS), 72 h, recovery 7 days after PSD. When compared NS, increased systolic all conditions: before...

Calcitonin gene-related peptide (CGRP) and its receptors are widely distributed in the nervous cardiovascular systems as a potent vasodilator; however, underlying mechanisms of action CGRP on regulation, such cooling-elicited hemodynamic perturbation (CEHP), still unclear. We used spectral crossspectral analyses to explore questions this study. Conscious rats were pretreated with antagonist CGRP_(8-37)-only, or following removal sympathetic influences using hexamethonium (HEX) guanethidine...

1. The aim of the present study was to examine role dopaminergic and glutamatergic receptors on different stages amphetamine (AMPH) sensitized effect in schedule-induced polydipsia (SIP) rats. 2. Three experiments were designed evaluate roles DAD2 receptor antagonist haloperidol (HAL) N-methyl d-aspartate MK-801 both induction expression stage AMPH sensitization SIP First, model tested again confirm previous findings. Second, HAL or co-administered with five consecutive days their examined...

Cooling causes hemodynamic instability as changes in blood pressure variability and heart rate (BPV, HRV). We observed that increased sympathomyogenic responses (SMR) very‐low frequency of BPV (VLF ) low (LF which were dependent on the evoked pressor to cooling; present study was designed examine whether α2‐adrenoceptor (AR) is involved such cooling effects rats. Hemodynamic telemetry monitored throughout experiments. Vehicle or yohimbine (YOH, 2.5 5.0 mg/kg) administered with a latency (5...

We investigated the mechanisms of hunting response, i.e. cold‐evoked vasoconstriction (CEC) and latter vasodilatation (CED) at lowest temperatures. Rats were immersed soles in a cage containing 2 cm iced water (4±2°C) for 10 min then responses through cooling (C) monitored by changes blood pressure heart rate with variability frequency domain: very low (VLF), (LF) high (HF). Firstly, we tested brain dopamine‐β hydroxylase (DBH) mechanisms. given lateral ventricularly (icv) DBH‐shRNA to...