A5075044379- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Animal Vocal Communication and Behavior
- Neural and Behavioral Psychology Studies
- Marine animal studies overview
- Visual perception and processing mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Advanced Memory and Neural Computing
- Retinal Development and Disorders
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- Genetic and phenotypic traits in livestock
- Advanced Fluorescence Microscopy Techniques
- Epilepsy research and treatment
- Hearing Loss and Rehabilitation
- Neural Networks and Applications
- Avian ecology and behavior
- Mosquito-borne diseases and control
- Isotope Analysis in Ecology
Monash University
2019-2024
Kagoshima University
2023-2024
Japan Science and Technology Agency
2020-2024
Discovery Institute
2019-2024
Australian Regenerative Medicine Institute
2019-2023
Technical University of Munich
2017-2018
Senckenberg Centre for Human Evolution and Palaeoenvironment
2017
University College London
2009-2016
Kyoto Prefectural University of Medicine
2003-2011
Kyoto University
1996-2009
We recorded the activity of midbrain dopamine neurons in an instrumental conditioning task which monkeys made a series behavioral decisions on basis distinct reward expectations. Dopamine responded to first visual cue that appeared each trial [conditioned stimulus (CS)] through initiated for decision while expecting trial-specific probability and volume. The magnitude neuronal responses CS was approximately proportional expectations but with considerable discrepancy. In contrast, appear...
Genetically encoded voltage indicators (GEVIs) promise to reveal the membrane potential of genetically targeted neuronal populations through noninvasive, chronic imaging large portions cortical space. Here we test a promising GEVI in mouse cortex during wakefulness, challenging condition due hemodynamic activity, and introduce straightforward projection method separate signal dominated by from activity. We expressed VSFP-Butterfly 1.2 plasmid layer 2/3 pyramidal cells visual electroporation...
Cortical computation is distributed across multiple areas of the cortex by networks reciprocal connectivity. However, how such connectivity contributes to communication between connected not clear. In this study, we examine sensory and motor cortices. We develop an eye movement task in mice combine it with optogenetic suppression two-photon calcium imaging techniques. identify a small region secondary (MOs) that controls movements reciprocally connects rostrolateral part higher visual...
Midbrain dopamine neurons signal reward value, their prediction error, and the salience of events. If they play a critical role in achieving specific distant goals, long-term future rewards should also be encoded as suggested reinforcement learning theories. Here, we address this experimentally untested issue. We recorded 185 three monkeys that performed multistep choice task which explored target among alternatives then exploited knowledge to receive one or two additional by choosing same...
Midbrain dopamine neurons impact neural processing in the prefrontal cortex (PFC) through mesocortical projections. However, signals conveyed by projections to PFC remain unclear, particularly at single-axon level. Here, we investigated dopaminergic axonal activity medial (mPFC) during reward and aversive processing. By optimizing microprism-mediated two-photon calcium imaging of axon terminals, found diverse axons responsive both stimuli. Some exhibited a preference for reward, while others...
Prepared movements are more efficient than those that not prepared for. Although changes in cortical activity have been observed prior to a forthcoming action, the circuits involved motor preparation remain unclear. Here, we use vivo two-photon calcium imaging uncover cortex during variable waiting periods forepaw reaching task mice. Consistent with previous reports, subset of neurons increased period; however, these did account for degree as defined by reaction time (RT). Instead,...
Nucleus magnocellularis (NM) is one of the subnuclei avian cochlear nucleus and has a role extracting temporal information sound from auditory nerve fibers (ANFs). Neurons in NM are varied along tonotopic axis synaptic transmission membrane excitability high-fidelity relay neurons at high to middle characteristic frequency (CF) regions. Here we have compared firing properties between ANFs vivo found that but not near threshold intensities, spike firings more phase-locked than CF region <500...
<b><i><i>Objective:</i></i></b> Televised images are the most common stimulus for provoking photosensitive seizures in persons. To inhibit persons who do or not have epilepsy, authors sought nonpharmacologic methods reducing levels of photic stimulation televised images. <b><i><i>Background:</i></i></b> The found two types pathophysiologic mechanisms (wavelength-dependent and quantity light–dependent mechanisms) photoparoxysmal responses (PPR). <b><i><i>Methods:</i></i></b> tested different...
Cortical plasticity is fundamental to motor recovery following cortical perturbation. However, it still unclear how this induced at a functional circuit level. Here, we investigated and underlying neural upon optogenetic suppression of area for eye movement. Using visually-guided movement task in mice, suppressed portion the secondary cortex (MOs) that encodes contraversive Optogenetic unilateral severely impaired on first day. subsequent days became inefficient capability was restored....
The initiation of goal-directed actions is a complex process involving the medial prefrontal cortex and dopaminergic inputs through mesocortical pathway. However, it unclear what information pathway conveys how impacts action initiation. In this study, we unveiled indispensable role axon terminals in encoding execution movements self-initiated actions.
Although wild bird rehabilitation facilities are important for the conservation of species, individuals may be kept within long periods, consequently posing a risk to infected with pathogens which they not naturally exposed. In turn, novel introduced through rescued migratory species. Avian malaria and West Nile fever avian diseases transmitted by mosquitoes. To understand transmission dynamics such at facilities, ecology vector mosquitoes, including species composition, seasonality, feeding...
Midbrain dopamine neurons impact neural processing in the prefrontal cortex (PFC) through mesocortical projections. However, signals conveyed by projections to PFC remain unclear, particularly at single-axon level. Here, we investigated dopaminergic axonal activity medial (mPFC) during reward and aversive processing. By optimizing microprism-mediated two-photon calcium imaging of axon terminals, found diverse responses axons, with some preferring others stimuli, a strong bias for latter...
Midbrain dopamine neurons impact neural processing in the prefrontal cortex (PFC) through mesocortical projections. However, signals conveyed by projections to PFC remain unclear, particularly at single-axon level. Here, we investigated dopaminergic axonal activity medial (mPFC) during reward and aversive processing. By optimizing microprism-mediated two-photon calcium imaging of axon terminals, found diverse axons responsive both stimuli. Some exhibited a preference for reward, while others...