A5037659742- Biosimilars and Bioanalytical Methods
- Monoclonal and Polyclonal Antibodies Research
- Algal biology and biofuel production
- Wildlife Ecology and Conservation
- Conservation, Biodiversity, and Resource Management
- Economic and Environmental Valuation
- Advanced Biosensing Techniques and Applications
- Hydrology and Watershed Management Studies
- CAR-T cell therapy research
- Diabetes Management and Research
- Coral and Marine Ecosystems Studies
- SARS-CoV-2 and COVID-19 Research
- Aquatic Ecosystems and Phytoplankton Dynamics
- Diabetes and associated disorders
- Land Use and Ecosystem Services
- Soil and Water Nutrient Dynamics
- Species Distribution and Climate Change
- Marine and fisheries research
- Water resources management and optimization
- Pancreatic function and diabetes
- Agricultural Innovations and Practices
- Protein purification and stability
- Forest Management and Policy
- Health Systems, Economic Evaluations, Quality of Life
- Marine Bivalve and Aquaculture Studies
Sanofi (Germany)
2016-2025
Beth Israel Deaconess Medical Center
2012-2025
Harvard University
2012-2025
Deaconess Hospital
2022-2025
Madison Area Technical College
2014-2023
Michigan State University
2014-2023
New York Proton Center
2023
Michigan Department of Natural Resources
2011-2022
Cyano Biotech (Germany)
2007-2017
Michigan United
2013-2015
Kramer, D. B., J. Hartter, A. E. Boag, M. Jain, K. Stevens, Ann Nicholas, W. McConnell, and Liu. 2017. Top 40 questions in coupled human natural systems (CHANS) research. Ecology Society 22(2):44. https://doi.org/10.5751/ES-09429-220244
Future sustainable energy production can be achieved using mass cultures of photoautotrophic microorganisms, which are engineered to synthesize valuable products directly from CO2 and sunlight. As cyanobacteria cultivated in large scale on non-arable land, these phototrophic bacteria have become attractive organisms for biofuels. Synechococcus sp. PCC 7002, one the cyanobacterial model organisms, provides many properties biofuel such as tolerance seawater high light intensities.Here, we...
Tropical forest conversion to pasture, which drives greenhouse gas emissions, soil degradation, and biodiversity loss, remains a pressing socio-ecological challenge. This problem has spurred increased interest in the potential of small-scale agroforestry systems couple sustainable agriculture with conservation, particularly rapidly developing areas tropics. In addition providing natural resources (i.e. food, medicine, lumber), have maintain higher levels greater biomass than lower diversity...
Agent-based models (ABMs) have been widely used to study socioecological systems. They are useful for studying such systems because of their ability incorporate micro-level behaviors among interacting agents, and understand emergent phenomena due these interactions. However, ABMs inherently stochastic require proper handling uncertainty. We propose a simulation framework based on quantitative uncertainty sensitivity analyses build parsimonious that serve two purposes: exploration the outcome...
Abstract In order to use science manage human–nature interactions, we need much more nuanced, and when possible, quantitative, analyses of the interplay among ecosystem services (ES), human well‐being (HWB), drivers both structure function, as well HWB. Despite a growing interest extensive efforts in ES research past decade, systematic quantitative work on linkages between HWB is rare existing literature, largely due lack indicators integrated models. Here, dependence ES, HWB, direct...
Evolving immunogenicity assay performance expectations and a lack of harmonized anti-drug antibody validation testing reporting tools have resulted in significant time spent by health authorities sponsors on resolving filing queries. Following debate at the American Association Pharmaceutical Sciences National Biotechnology Conference, group was formed to address these gaps. Over last 3 years, 44 members from 29 organizations (including 5 Europe 10 FDA) discussed gaps understanding...
Abstract The Mekong River basin (MRB) is a transboundary that supports livelihoods of over 70 million inhabitants and diverse terrestrial-aquatic ecosystems. This critical lifeline for people ecosystems under transformation due to climatic stressors human activities (e.g., land use change dam construction). Thus, there an urgent need better understand the changing hydrological ecological systems in MRB develop improved adaptation strategies. This, however, hampered partly by lack sufficient,...
Understanding the linkages between ecosystem services (ES) and human well-being (HWB) is crucial to sustain flow of ES for HWB. The Millennium Ecosystem Assessment (MA) provided a state-of-the-art synthesis such knowledge. However, due complexity HWB, there are still many knowledge gaps, in particular lack quantitative indicators integrated models based on MA framework. To fill some these research needs, we developed index system measure assessed impacts an external driver – 2008 Wenchuan...
The 2017 11th Workshop on Recent Issues in Bioanalysis took place Los Angeles/Universal City, California, 3-7 April with participation of close to 750 professionals from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations and regulatory agencies worldwide. WRIB was once again a 5-day, week-long event - full immersion week bioanalysis, biomarkers immunogenicity. As usual, it specifically designed facilitate sharing, reviewing, discussing agreeing...
Cyanobacteria are phototrophic prokaryotes that convert inorganic carbon as CO2 into organic compounds at the expense of light energy. They need only nutrients and can be cultivated to high densities using non-arable land seawater. This has made cyanobacteria attractive organisms for production biofuels chemical feedstock. Synechocystis sp. PCC 6803 is one most widely used cyanobacterial model strains. Based on its available genome sequence genetic tools, been genetically modified produce...
The 2016 10th Workshop on Recent Issues in Bioanalysis (10th WRIB) took place Orlando, Florida with participation of close to 700 professionals from pharmaceutical/biopharmaceutical companies, biotechnology contract research organizations, and regulatory agencies worldwide. WRIB was once again a weeklong event - A Full Immersion Week for PK, Biomarkers Immunogenicity. As usual, it is specifically designed facilitate sharing, reviewing, discussing agreeing approaches address the most current...
The 18th Workshop on Recent Issues in Bioanalysis (18th WRIB) took place San Antonio, TX, USA May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest bioanalysis. WRIB included 3 Main Workshops 7 Specialized that together spanned 1 week allow an exhaustive thorough coverage all major issues bioanalysis biomarkers, immunogenicity, gene therapy, cell therapy...
BackgroundEMD 521873 (Selectikine), an immunocytokine comprising a DNA-targeting antibody, aimed at tumour necrosis, fused with genetically modified interleukin-2 (IL-2) moiety, was investigated in this first-in-human phase I study.MethodsPatients had metastatic or locally advanced solid tumours failing previous standard therapy. Selectikine administered as 1-hour intravenous infusion on 3 consecutive days, every weeks. A subgroup of patients also received 300 mg/m2 cyclophosphamide day 1...
Abstract Mature thrombin activatable fibrinolysis inhibitor (TAFIa) is a carboxypeptidase that stabilizes fibrin clots by removing C-terminal arginines and lysines from partially degraded fibrin. Inhibition of TAFIa stimulates the degradation may help to prevent thrombosis. Applying lead finding approach based on literature-mining, we discovered anabaenopeptins, cyclic peptides produced cyanobacteria, were potent inhibitors with IC 50 values as low 1.5 nM. We describe isolation structure...
Journal Article Serotypes and virutypes of enteropathogenic enterohaemorrhagic Escherichia coli strains from stool samples children with diarrhoea in Germany Get access E. Kozub‐Witkowski, Kozub‐Witkowski LADR GmbH, Medizinisches Versorgungszentrum, Dr. Kramer & Kollegen, Geesthacht, Search for other works by this author on: Oxford Academic Google Scholar G. Krause, Krause National Reference Laboratory coli, Centre Infectiology Pathogen Characterization, Federal Institute Risk Assessment,...