A5047505420- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Sleep and Work-Related Fatigue
- Misinformation and Its Impacts
- Intracerebral and Subarachnoid Hemorrhage Research
- Atherosclerosis and Cardiovascular Diseases
- Fungal Infections and Studies
- vaccines and immunoinformatics approaches
- Primary Care and Health Outcomes
- Chemical Safety and Risk Management
- Carbohydrate Chemistry and Synthesis
- Nursing Education, Practice, and Leadership
- Regulation of Appetite and Obesity
- Neuroinflammation and Neurodegeneration Mechanisms
- IL-33, ST2, and ILC Pathways
- Medical History and Innovations
- Vitamin C and Antioxidants Research
- Enzyme Production and Characterization
- Historical Psychiatry and Medical Practices
- Vaccine Coverage and Hesitancy
New York City Health and Hospitals Corporation
2021-2024
Martin Luther University Halle-Wittenberg
2017-2021
Faculty (United Kingdom)
2021
University Hospital in Halle
2021
Office of Management
2021
New York University
2021
Luther University
2018
Institut Virion\Serion
2015
Technische Universität Braunschweig
2009
Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of impaired NK functionality on risk obesity. In vitro investigations demonstrated a decreased IFN- γ secretion and cytotoxicity human cells against tumor after preincubation adipokine leptin. addition, leptin incubation expression activating receptors. animal...
Aspergillus fumigatus is a common airborne fungal pathogen for humans. It frequently causes an invasive aspergillosis (IA) in immunocompromised patients with poor prognosis. Potent antifungal drugs are very expensive and cause serious adverse effects. Their correct application requires early specific diagnosis of IA, which still not properly achievable. This work aims to detection A. by immunofluorescence the generation recombinant antibodies ELISA.The antigen Crf2 was isolated from human...
Glycation and the accumulation of advanced glycation end products (AGEs) are known to occur during normal aging but also in progression several diseases, such as diabetes. Diabetes type II both lead impaired wound healing. It has been demonstrated that macrophages play an important role healing, however, underlying causes remain unknown. Elevated blood glucose levels well elevated methylglyoxal (MGO) diabetic patients result increase AGEs. We used MGO investigate influence AGEs on...
Obesity leads to an altered adipocytokine production negatively effecting the function of natural killer cells (NK cells), which are important effector innate immune system. NK provide a defence against tumour or virus infected and have different activating inhibitory surface receptors distinguish between normal transformed cells. One group sialic acid-binding immunoglobulin-like lectins (Siglecs). The aim this study was compare expression Siglecs-7, -9 -10 on from weight obese subjects....
The sensitivity of a K39 ELISA (Leishmania IgG, Virion/Serion) for the detection antibodies in patients with imported leishmaniasis was compared an immunofluorescence assay (IFA), which applied as "golden standard". retrospective study comprised 93 IFA-positive or borderline sera from 42 visceral (n = 16) cutaneous 26) leishmaniasis. Patients had acquired infection predominately Mediterranean area Middle East. Leishmania species donovani/infantum, tropica, major) were identified by real-time...
Hyperleptinemia, associated with obesity, is related immune dysfunction and carcinogenesis. Natural Killer (NK) cells, a major component of the innate system are mediators anti-tumor immunity most actively migrating cells among leukocytes. Actin rearrangement, promoted by cofilin plays central role in cellular migration. Leptin affects phosphorylation-dependent activity thus actin remodeling. We used human NK-92 to explore vitro effects leptin on co-localization F-actin morphological changes...
Sialic acids are terminal sugars on the cell surface that found all types including immune cells like natural killer (NK) cells. The attachment of sialic to different glycan structures is catalyzed by sialyltransferases in Golgi. However, expression pattern NK and their after activation has not yet been analyzed. Therefore, present study determines which expressed human if with IL-2 changes sialylation was analyzed three lines NK-92, NKL, KHYG-1 primary NK-92 were cultured absence or...
Abstract Meningiomas are the most common non-malignant intracranial tumors. Like tumors, meningiomas prefer anaerobic glycolysis for energy production (Warburg effect). This leads to an increased synthesis of metabolite methylglyoxal (MGO). is known react with amino groups proteins. reaction called glycation, thereby building advanced glycation endproducts (AGEs). In this study, we investigated influence on two meningioma cell lines, representing WHO grade I (BEN-MEN-1) and III (IOMM-Lee)....
Abstract The balance between protein synthesis and degradation regulates the amount of expressed proteins. This turnover is usually quantified as half-life time. Several studies suggest that decreases with age leads to increased deposits damaged non-functional Glycation an age-dependent, non-enzymatic process leading posttranslational modifications, so-called advanced glycation endproducts (AGE), which damage proteins lead aggregation. AGE are formed by Maillard reaction, where carbonyls...
A new genetically derived variant of the glucosyltransferase from Streptococcus oralis has been characterized physicochemically and kinetically. Compared with industrially used Leuconostoc mesenteroides, enzyme GTF-R S628D possesses 25 times higher affinity for specific glucosylation glucose. For a concept integrated reaction product isolation, fluidized bed reactor in situ removal was applied. The technical feasibility applicability kinetic models adsorption could be demonstrated....