A5067805038- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Anatomy and Medical Technology
- Innovations in Medical Education
- Foot and Ankle Surgery
- Global Health and Surgery
- Exercise and Physiological Responses
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- Global Health Workforce Issues
- Orthopedic Surgery and Rehabilitation
- Surgical Simulation and Training
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Lower Extremity Biomechanics and Pathologies
- Orthopaedic implants and arthroplasty
- Pelvic and Acetabular Injuries
- Prenatal Substance Exposure Effects
- Dietary Effects on Health
- Birth, Development, and Health
- Grit, Self-Efficacy, and Motivation
- Dialysis and Renal Disease Management
- Cultural Competency in Health Care
- Elbow and Forearm Trauma Treatment
- Central Venous Catheters and Hemodialysis
Martin Luther University Halle-Wittenberg
2016-2025
University Hospital in Halle
2024
Luther University
2012-2022
Institute of Cell Biology and Neurobiology
2019-2021
Wittenberg University
2020
Tokyo Women's Medical University
2020
Obesity is associated with an elevated risk for several types of cancer and thus a major health hazard. However, the mechanism between overweight susceptibility still elusive. Leptin, mainly produced by adipocytes links food intake energy expenditure. In addition, recent studies have shown immunomodulatory impact leptin on NK cells. The purpose present study was to investigate whether stimulation cells from obese humans leads altered functions as compared lean subjects. On basis body mass...
Obesity is associated with alterations in functionality of immune cells, like macrophages and natural killer (NK) leading to an increased risk for severe infections several cancer types. This study aimed examine cell populations functional NK parameters focusing on subset phenotypes normal-weight obese humans. Therefore, peripheral blood mononuclear cells (PBMCs) were isolated from individuals analyzed by flow cytometry. Results show no significant changes the frequency monocytes, B...
Objective Natural killer (NK) cells are the first defense against malignant cells, and their functions severely impaired in individuals with obesity. However, it is not known whether can be re-activated after weight loss. The alterations of NK cell fat mass reduction were investigated. Methods Thirty-two healthy adults obesity divided into control experimental groups. Participants group performed a 3-month program exercise training nutrition. Anthropometric, physiological, metabolic...
A large variety of imaging techniques is an integral part modern medicine. Introducing radiological into the dissection course serves as a basis for improved learning anatomy and multidisciplinary in pre-clinical medical education. Four different (ultrasound, radiography, computed tomography, magnetic resonance imaging) were performed embalmed human body donors to analyse possibilities limitations respective this peculiar setting. The quality ultrasound radiography images was poor,...
Abstract A tissue-engineered oesophageal scaffold could be very useful for the treatment of pediatric and adult patients with benign or malignant diseases such as carcinomas, trauma congenital malformations. Here we decellularize rat oesophagi inside a perfusion bioreactor to create biocompatible biological scaffolds that mimic native architecture, resist mechanical stress induce angiogenesis. Seeded allogeneic mesenchymal stromal cells spontaneously differentiate (proven by gene-, protein...
Cognitive function declines in parallel to the decrease glomerular filtration rate, best epitomized by markedly reduced cerebral performance patients undergoing maintenance haemodialysis [chronic kidney disease stage 5 dialysis (CKD5D)]. Aside from structural permanent damage, there seems be a reversible part of low cognitive performance. The potential effect single session on remains still elusive. aim study was assess using widespread test battery and avoiding excluding effects circadian...
Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of impaired NK functionality on risk obesity. In vitro investigations demonstrated a decreased IFN- γ secretion and cytotoxicity human cells against tumor after preincubation adipokine leptin. addition, leptin incubation expression activating receptors. animal...
Patients with chronic kidney disease (CKD) exhibit a high prevalence of neuropsychiatric alterations, including depression and behavioural changes. CKD is also associated decreased physical activity not fully explained by co-morbidities. In patients without CKD, the brain-derived neurotropic factor (BDNF) as well endogenous NOS inhibitor asymmetric dimethylarginine (ADMA) had been suspected to be involved in major depression. The aim our study was examine role ADMA BDNF behaviour...
Abstract Purpose Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study assess long-term effects BS on chronic low-grade inflammation related severe obesity. Moreover, meaning type procedure as well remission 2 diabetes (T2D) for status up 4 years after analyzed. Materials and Methods In a retrospective cohort including 163 patients at baseline, metabolic parameters were assessed time points: before (baseline),...
Background: Calcaneal osteotomy is frequently used in correcting various foot deformities. Minimally invasive procedures such as minimally calcaneus (MICO) have become established because of their more favorable risk profile. The literature describes a safe zone for performing the to protect nerve structures. Overall, existence “safe zone” remains controversial. aim this anatomical study was determine injury context MICO. Methods: Twenty fresh frozen specimens were randomized V-shaped and...
Background: Subtalar arthrodesis is a commonly performed procedure for the treatment of posttraumatic or primary osteoarthritis and several hindfoot deformities. The objective this study to evaluate efficacy safety minimally invasive technique cartilage removal subtalar joint using modified sinus tarsi approach. Methods: An anatomical was on 8 pairs fresh frozen cadaveric feet. A 2.5-cm approach used access joint. Cartilage in 2 groups either 13-mm Shannon burr (GB) curette (GC) with...
In Ghana, adolescents represent 22% of the total population. The rates adolescent pregnancies are high. Of all births registered in country 2014, 30% were by adolescents, and 14% aged between 15 19 years had begun childbearing. Pregnancies deliveries accompanied more risks as compared to older women. aim study was explore long-term effects on subsequent socioeconomic status A cross-sectional interviewer-performed survey a purposive sample 400 women one community Northern Ghana conducted....
<b><i>Background: </i></b>Adiponectin is secreted by adipose tissue and exerts high abundance an anti-inflammatory potential. However, only little information exists about the expression profiles of adiponectin its recently identified receptor CDH13 in non-tumorous human tissues their association to clinical parameters. <b><i>Methods:</i></b> The levels were analyzed heart, liver, kidney, spleen, skin, blood vessels, peripheral nerve bone...
Orthogonal plate osteosynthesis enhances fixation stability in periprosthetic femur fractures. Another option are locking attachment plates (LAP) allowing bicortical screw placement lateral to the prosthesis stem. Stability of with two LAP (2LAP) was compared anterolateral orthogonal (OP) one a fracture model. In six pairs fresh frozen human femora cemented Charnley hip prosthesis, transverse osteotomy set distal tip simulating Vancouver type B1 fracture. Each pair instrumented using...
Background Obesity is a risk factor for various types of infectious diseases and cancer. The increase in adipose tissue causes alterations both adipogenesis the production adipocyte-secreted proteins (adipokines). Since natural killer (NK) cells are host's primary defense against virus-infected tumor cells, we investigated how adipocyte-conditioned medium (ACM) affects functions two distinct human NK cell subsets. Methods Isolated peripheral blood mononuclear (PBMCs) were cultured with...
Obesity leads to an altered adipocytokine production negatively effecting the function of natural killer cells (NK cells), which are important effector innate immune system. NK provide a defence against tumour or virus infected and have different activating inhibitory surface receptors distinguish between normal transformed cells. One group sialic acid-binding immunoglobulin-like lectins (Siglecs). The aim this study was compare expression Siglecs-7, -9 -10 on from weight obese subjects....
Anthropometric characteristics of athletes are considered to be an important determinant success in sport. The aim the present study was compare several anthropometric parameters and subjective professional elite triathletes with profiles cyclists sportive students. In total 93 volunteers (21 male female triathletes, 26 as a control group 46 students) participated this study. Eight different were measured five-page questionnaire containing 35 general questions had completed. Interestingly,...