A5048332757- Nutrition and Health in Aging
- Frailty in Older Adults
- Health Systems, Economic Evaluations, Quality of Life
- Nutritional Studies and Diet
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Body Composition Measurement Techniques
- Genetics and Neurodevelopmental Disorders
- Adipose Tissue and Metabolism
- Asthma and respiratory diseases
- COVID-19 Pandemic Impacts
- Cytokine Signaling Pathways and Interactions
- Dietary Effects on Health
- Virus-based gene therapy research
- Psychosomatic Disorders and Their Treatments
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Genetic Associations and Epidemiology
- Food Allergy and Anaphylaxis Research
- Functional Brain Connectivity Studies
- Bone health and treatments
- GDF15 and Related Biomarkers
- Chronic Disease Management Strategies
- Immunodeficiency and Autoimmune Disorders
- IL-33, ST2, and ILC Pathways
National University of Singapore
2009-2025
National University Health System
2020
Analysis of cross-reactivity between the nematode Ascaris ssp. and dust mites, two important allergen sources in tropics, will contribute understanding their influence on asthma atopy. The objective this study was to investigate immunoglobulin E (IgE) domestic mites tropics.Sera from 24 asthmatic patients were used ELISA immunoblotting IgE-binding inhibition assays using Ascaris, Blomia tropicalis Dermatophagoides pteronyssinus extracts recombinants Blo t 10, ABA-1 13 as competitors....
Asian studies on how physical tests predict short-term mortality in elderly are scarce. We assessed handgrip strength and timed-up-and-go (TUG) as such predictors among Chinese Singapore. Prospective cohort study. Community-dwelling used data from 13,789 subjects the prospective, population-based Singapore Health Study, who had a mean age of 74 (range 63 to 97) years at time measurements. Subjects underwent assessment for TUG. They were followed via linkage with nationwide death registry...
Abstract Background Weak handgrip strength and slow timed up-and-go (TUG) time are known risk factors for hospitalization among older adults; however, few studies have investigated the relationships between these physical tests future costs. Methods We used data from 13,613 participants in population-based Singapore Chinese Health Study who underwent assessment TUG at a mean age of 74 years. Hospitalization costs subsequent year, those survived least one year thereafter, were ascertained via...
Our study evaluated the prospective association between consumption of caffeine-containing beverages at midlife and risk physical frailty late life within a population-based cohort Chinese adults living in Singapore over follow-up period 20 years.Prospective study.We used data from 12,583 participants baseline third interviews Health Study (SCHS). Participants had mean age 53 years (1993-1998), 73 during (2014-2017).At baseline, habitual was using validated semi-quantitative food-frequency...
Abstract Background Although obesity can be clinically defined by body mass index (BMI), waist circumference, percent fat, or visceral fat area, it is unclear which specific measure best associated with mobility disability in oldest-old adults. Methods Among 589 Chinese participants aged 85 years and older a population-based cohort Singapore, we measured computed BMI, estimated appendicular skeletal muscle mass, area using bioelectrical impedance analysis, evaluated the Loco-Check...
Among older adults, living alone is often associated with higher risk of Emergency Department (ED) admissions. However, adults are very heterogeneous in terms health. As more choose to live independently, it remains unclear if the association between and ED admissions moderated by health status. We studied admission outcomes (number admissions, inpatient days costs) among without multimorbidity.We used data from 16,785 individuals third follow-up Singapore Chinese Health Study, a...
Dumbbell-shaped DNA minimal vectors lacking nontherapeutic genes and bacterial sequences are considered a stable, safe alternative to viral, nonviral, naked plasmid-based gene-transfer systems. We investigated novel molecular features of dumbbell aiming reduce vector size improve the expression noncoding or coding RNA. minimized small hairpin RNA (shRNA) microRNA (miRNA) expressing in down 130 bp generating smallest genetic reported. This was achieved by using H1 promoter with integrated...
Abstract Background It is unclear if improving diet quality after midlife could reduce the risk of physical frailty at late life. We aimed to associate changes in with Methods Diet 12,580 participants from Singapore Chinese Health Study was assessed Dietary Approaches Stop Hypertension (DASH) scores baseline (1993–1998; mean age 53 years) and follow-up 3 (2014–2016; 73 years). Physical using modified Cardiovascular phenotype 3. Multivariable logistic regressions examined associations between...
Abstract Converging evidence suggests that handgrip strength is linked to cognition in older adults, and this may be subserved by shared age-related changes brain function structure. However, the interplay among strength, functional connectivity, cognitive remains poorly elucidated. Hence, our study sought examine these relationships 148 community-dwelling adults. Specifically, we examined segregation, a measure of organization sensitive ageing decline, its associations with function. We...
Recent experimental work has identified CXCL9 as a promoter for the differentiation of osteoclast progenitors into osteoclasts, with resultant bone resorption. However, no human study validated an association between this chemokine and osteoporosis or fracture risk. We conducted matched case-control nested in prospective, population-based Singapore Chinese Health Study. Fifty-five men 119 women incident hip fractures, occurring median 6.2 years after blood collection, were individually to...
Telomere attrition has been proposed as a hallmark of aging. We previously reported on the association between blood leukocyte telomere length (LTL) at midlife and risk chronic diseases mortality.In this study, we investigated effect LTL genetic proxies 5 markers aging outcomes, namely handgrip strength, timed up-and-go (TUG), Singapore-modified Mini-Mental State Examination (SM-MMSE) scores, anxiety, depression indices, measured after median 20-year follow-up in Singapore Chinese Health...
Although age at menopause has been linked to higher risk of physical frailty in later life, little is known about other reproductive factors. Our study aimed investigate the associations between 1) menarche, 2) natural menopause, 3) duration period, 4) number children, 5) use oral contraceptives (OCP), and 6) hormone replacement therapy (HRT) with late life. We used data from 5934 women Singapore Chinese Health Study who experienced participated third follow-up interviews when was assessed....
Abstract Background Adult height has been associated with handgrip strength, which is a surrogate marker of physical frailty. However, it uncertain if this association causative or due to confounding bias. Methods We evaluated pairwise associations among adult height, and genetically determined (using polygenic score [PGS] for in mediation framework 2-sample Mendelian randomization approach) by means multivariable regression model using prospective cohort Chinese living Singapore....
Abstract Older adults living alone are at higher risk of mortality, morbidity and healthcare utilization. As more older live alone, Emergency Department (ED) admissions could rapidly increase, particularly among those with multimorbidity. We studied the association on ED used data from 16,785 population-based Singapore Chinese Health Study (mean age: 73 years, range: 61-96 years) who were interviewed in 2014-2016 for arrangements medical history. Participants followed-up one year admission...
Abstract Background How obesity earlier in life impacts upon mobility dysfunctions late is not well understood. Pernicious effects of excess weight on the musculoskeletal system and are well-recognized. However, increasingly more data support link to overall motor defects that regulated brain. Objectives To assess causal relationship between body mass index (BMI) at midlife performance Timed Up-and-Go test (TUG) among a population-based longitudinal cohort Chinese adults living Singapore....