A5029156022- Hemoglobin structure and function
- Heme Oxygenase-1 and Carbon Monoxide
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Vaccine Coverage and Hesitancy
- Membrane Separation Technologies
- Liver Disease Diagnosis and Treatment
- Smoking Behavior and Cessation
- Epigenetics and DNA Methylation
- Dietary Effects on Health
- Biochemical effects in animals
- Lung Cancer Treatments and Mutations
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Bone and Joint Diseases
- Impact of Light on Environment and Health
- Solid State Laser Technologies
- Diet and metabolism studies
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Hip disorders and treatments
- Heavy Metal Exposure and Toxicity
- Obesity, Physical Activity, Diet
- Water Treatment and Disinfection
- Chronic Disease Management Strategies
Peking Union Medical College Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Shanghai Jiao Tong University
2020-2022
Ministry of Education of the People's Republic of China
2016-2019
Northwest University
2015-2019
Guangzhou Medical University
2019
Murdoch University
2017
Objective The hepatotoxicity of exposure to a single heavy metal has been examined in previous studies. However, there is limited evidence on the association between metals mixture and non-alcoholic fatty liver disease (NAFLD) metabolic-associated (MAFLD). This study aims investigate associations 13 urinary metals, individually jointly, with NAFLD, MAFLD, MAFLD components. Methods included 5,548 adults from National Health Nutrition Examination Survey (NHANES) 2003–2018. Binary logistic...
Whether exposure to organophosphate esters (OPEs) is associated with metabolic dysfunction-associated fatty liver disease (MAFLD) and nonalcoholic (NAFLD) remains unclear. A healthy diet crucial health dietary intake also an important route for OPEs exposure. However, the joint associations of OPEs, quality, effect modification by quality remain unknown. This study comprised 2618 adults complete data on 6 urinary metabolites, 24 h recalls, definitions NAFLD MAFLD from 2011-2018 National...
Abstract Background The impacts of long-term exposure to air pollution on the risk subsequent non-alcoholic fatty liver disease (NAFLD) among participants with type 2 diabetes (T2D) is ambiguous. modifying role Life’s Essential 8 (LE8) remains unknown. Methods This study included 23,129 T2D at baseline from UK Biobank. Annual means nitrogen dioxide (NO ), oxides X and particulate matter (PM 2.5 , PM 2.5–10 10 ) were estimated using land-use regression model for each participant. associations...
The proportion of alcohol-induced osteonecrosis the femoral head (ONFH) in all ONFH patients was 30.7%, with males prevailing among mainland China (70.1%). Matrix metalloproteinase 2 (MMP2), a member MMP gene family, encodes enzyme MMP2, which can promote osteoclast migration, attachment, and bone matrix degradation. In this case–control study, we aimed to investigate association between MMP2 Chinese males. total, 299 396 healthy controls were recruited for study. Five single-nucleotide...
1. Protano C, Vitali M. The new danger of thirdhand smoke: why passive smoking does not stop at secondhand smoke. Environ Health Perspect. 2011;119(10):A422. doi:10.1289/ehp.1103956. CrossRef Google Scholar
Control of biofouling on seawater reverse osmosis (SWRO) membranes is a major challenge as treatments can be expensive, damage the membrane material and often biocides do not remove polymers in which bacteria are embedded. Biological control has been largely ignored for control. The objective this study was to demonstrate effectiveness xanthine oxidase enzyme against complex fouling communities then identify naturally occurring bacterial strains that produce free radical generating enzyme....
// Bin Li 1, 2, * , Wenhui Zhao 3, Jingjie 2 Mengdan Yan Zhilan Xie Yuanyuan Zhu Chao Chen Tianbo Jin 4 1 School of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, China National Engineering Research Center for Miniaturized Detection Systems, 3 Department Anesthesiology, Shaanxi Provincial Tumor Hospital, 710061, Xi'an Tiangen Precision Medical Institute, 710075, These authors have contributed equally to this work Correspondence to: Jin, email: jintianbo@gmail.com Chen,...
Abstract Background The impact of cardiometabolic multimorbidity (CMM) on functional dependency (FD) is well established, but the temporal effect FD CMM and its mechanisms remain underexplored. Design A multicohort study pooled data from three international cohorts. Setting Data were sourced Health Retirement Study (USA), China Longitudinal (China) Survey Health, Ageing in 18 European countries. Methods was defined as inability to perform basic activities daily living (ADLs) instrumental...
Glutaraldehyde-polymerized porcine hemoglobin (pPolyHb) is a hemoglobin-based oxygen carrier currently being developed as potential red blood cell substitute. We assessed the protective effect of pPolyHb on transient focal cerebral ischemia/reperfusion (I/R) injury. Several outcomes were tested, including infarct size, neurological score, production inflammatory factors, and markers oxidative status. Our results show that can not only significantly reduce volume improve but also inhibit...
Background: Numerous observational studies have documented an association between the circadian rhythm and composition of gut microbiota. However, bidirectional causal effect morning chronotype on microbiota is unknown. Methods: A two-sample Mendelian randomization study was performed, using summary statistics from European Consortium those largest available genome-wide meta-analysis, conducted by MiBioGen consortium. The inverse variance-weighted (IVW), weighted mode, median, MR-Egger...
Polymerized porcine hemoglobin (pPolyHb) exhibits a protective effect on ischemia/reperfusion of organ grafts. A series experiments were performed to explore the underlying cytoprotective mechanisms pPolyHb pretreatment H2O2-induced cell death and apoptosis. The results showed that augmented heme oxygenase-1 (HO-1) expression, at same time, decreased phosphorylation JNK/p38 mitogen-activated protein kinase (MAPK) intracellular ROS generation in H2O2-treated HUVECs. Moreover, inhibition HO-1...
Background: The causal connection between morning diurnal preference and psychiatric disorders remains enigmatic. Using bidirectional two-sample Mendelian randomization (MR), we aim to explore the potential associations seven prominent disorders. Methods: MR is a genetic epidemiological method that leverages variants as instrumental variables infer exposures outcomes. We obtained data from genome-wide association study (GWAS) datasets identified 252,287 individuals people. Psychiatric...
Abstract Background Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent malignant neoplasms upper respiratory tract. Studies have confirmed that an unstable chromosome constitution promotes progress laryngeal tumorigenesis, and ACYP2 has been as a telomere length‐related gene. However, to date, association between polymorphisms LSCC susceptibility not investigated. Methods We performed this study explore effect 11 single‐nucleotide (SNPs) in on Chinese Han males....
Abstract Background Rapid mutation of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is sweeping world and delaying full reopening society. Acceleration vaccination process may be key element in winning race against this virus. We examine factors associated with personal considerations accessibility to corona disease 2019 (COVID-19) metropolises China. Methods This multi-center, cross-sectional research was conducted using online questionnaires from April 1 June 1,...
In this study, we aimed to identify concerns and stimuli regarding COVID-19 vaccination acceptance compare the findings by occupation. We conducted a cross-sectional study of individuals vaccinated against between 1 April 30 June 2021 in four metropolitan areas China. A total 20 863 participants completed questionnaires, 767 which were eligible for analysis. used ordered logistic regression assess association with hesitancy according Farmers mainly concerned about quality vaccines (adjusted...
Breast cancer is the dominant female and top cause of deaths in women among world. The susceptible genes are critical risk factors for both hereditary sporadic breast cancers. incidence carcinoma carriers with mutated relative might increase comparison that normal population. These be applied populated screening clinical treatment, order to improve survival patients. This study concluded some involved various key elementary processes cell life, including DNA repair, cycle regulation,...
Polymerized porcine hemoglobin (pPolyHb), which was synthesized from chemically modified hemoglobin, can carry and deliver oxygen to tissues in addition restoring intravascular volume. Assessment of the inflammatory response generated host is a part overall safety evaluation pPolyHb. In this study, we measured levels IL-1β, IL-10, CD11b/CD18 pPolyHb stimulation, both vivo (in rats) vitro. Our results suggest that these indicators are not statistically changed by pPolyHb, indicating...