A5022335997- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Kruppel-like factors research
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Ubiquitin and proteasome pathways
- Eosinophilic Disorders and Syndromes
- Multiple and Secondary Primary Cancers
- Global Cancer Incidence and Screening
- Blood disorders and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Colorectal Cancer Screening and Detection
- Lipid metabolism and disorders
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Cancer Treatment and Pharmacology
- Cancer survivorship and care
- Genomics and Chromatin Dynamics
- Peptidase Inhibition and Analysis
The University of Texas MD Anderson Cancer Center
2017-2022
Mayo Clinic
2014-2015
Mayo Clinic in Arizona
2014
WinnMed
2014
Current prognostication in primary myelofibrosis (PMF) is based on the dynamic international prognostic scoring system (DIPSS)-plus, which employs clinical and cytogenetic variables. We recently reported DIPSS-plus independent significance for calreticulin (CALR) (favorable) ASXL1 (unfavorable) mutations. In current study, 570 PMF patients were recruited derivation (n=277) validation (n=293) of a molecular model these two Survival was longest CALR(+)ASXL1(-) (median 10.4 years) shortest...
CALR (calreticulin) trails JAK2 as the second most mutated gene in essential thrombocythemia (ET). Mutant ET is a result of frameshift mutations, caused by exon 9 deletions or insertions; type-1, 52-bp deletion (p.L367fs*46), and type-2, 5-bp TTGTC insertion (p.K385fs*47) variants constitute more than 80% these mutations. The current study includes total 1027 patients divided into test (n = 402) validation 625) cohorts. Among 402 cohort, 227 (57%) harbored JAK2, 11 (3%) Myeloproliferative...
Colony stimulating factor 3 receptor gene (CSF3R) mutations have recently been associated with chronic neutrophilic leukemia (CNL). Fourteen patients CSF3R-mutated CNL (median age 67 years; 57% males) were screened for additional mutations; 8 (57%) and 5 (38%) harbored an ASXL1 and/or SETBP1 mutation (two expressed both), respectively. Two developed blastic transformation, both SETBP1-mutated ASXL1-unmutated, whereas two other cases evolved into myelomonocytic (CMML), ASXL1-mutated...
So far, 23 germline susceptibility loci have been associated with multiple myeloma (MM) risk. It is unclear whether the genetic variation MM also predisposes to its precursor, monoclonal gammopathy of undetermined significance (MGUS). Leveraging 2434 cases, 754 MGUS and 2 independent sets controls (2567/879), we investigated potential shared by (1) performing genome-wide association studies (GWAS); (2) validating a polygenic risk score (PRS) based on established (MM-PRS) MM, for first time...
8049 Background: Monoclonal gammopathy of unknown significance (MGUS) and smoldering multiple myeloma (SMM) are monoclonal gammopathies that precede (MM). Although considered asymptomatic, patients diagnosed with these conditions at greatly increased risk developing MM. There is currently limited to no information on quality life (QOL) or cancer worry/anxiety burden for MGUS SMM. Methods: We implemented a longitudinal QOL cancer-related worry assessment in an observational cohort study SMM...
Abstract Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as quantitative trait loci (eQTLs) showing strong associations with gene levels. We performed an association study to test whether eQTLs genes reported associated prognosis MM are directly measures adverse outcome. Using the genotype‐tissue portal, we identified a...
Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic or gain other chromosomes. We employed the Illumina GoldenGate genotyping platform to quantitate heterozygosity (LOH) across genome primary tumors, revealing strong biases favoring alleles from FVB parent. While allelic bias was not observed on chromosomes, many showed concerted LOH (C-LOH) all one parent a pattern consistent with cytogenetic observations. Surprisingly, comparison tumor samples...
Abstract Purpose: Although Hispanics are the fastest-growing minority population in United States, little is known regarding clinical attributes of multiple myeloma (MM) this group. Here, we ascertain unique MM disease characteristics when compared to a multiethnic patient population. Methods: Self-reported 152 Hispanic, 219 non-Hispanic black (NHB), and 275 white (NHW) cases were selected from MD Anderson Cancer Center Patient Survivor Cohort. demographics, history premalignancy, (Ig)...
Abstract Distinct racial disparities are evident in CRC prognosis with Black patients experiencing worse outcomes than Hispanics and Whites. In a prior study of Health Related Quality Life (HR-QoL) cohort patients, we observed that minority experienced lower HR-QoL scores compared to White patients. Therefore, this study, focused on the identification patterns relationship differences prognosis. (N=450), Hispanic (N=366), (N=316) within 1 year diagnosis at MD Anderson Cancer Center completed...