Marcin Kruszewski
A5056385179- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Chronic Lymphocytic Leukemia Research
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Glycosylation and Glycoproteins Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
University of Bydgoszcz
2014-2023
Abstract Telomeres are involved in processes like cellular growth, chromosomal stability, and proper segregation to daughter cells. Telomere length measured leukocytes (LTL) has been investigated different cancer types, including multiple myeloma (MM). However, LTL measurement is prone heterogeneity due sample handling study design (retrospective vs. prospective). genetically determined; genome-wide association studies identified 11 SNPs that, combined a score, can be used as genetic...
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) are characterized by genomic instability, which may arise from the global hypomethylation of DNA. The active DNA demethylation process be linked with aberrant methylation can involved in leukemogenesis. levels 5-methylcytosine oxidation products were analyzed minimally invasive material: cellular peripheral blood cells urine patients AML MDS along control group, using isotope-dilution two-dimensional ultra-performance liquid...
Summary Over the past four decades, remarkable progress has been made in treatment and prognosis of multiple myeloma ( MM ), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for efficacy. Drug can be innate so driven by genes involved drug metabolism pathways. We performed association study 71 germline variants within those pathways ABCB 1 , ABCC 2 ABCG their regulators NR 1I2/ PXR 1I3/ CAR ) I nternational M ultiple yeloma r ESE arch (IMMEnSE) consortium,...
Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence risk developing multiple myeloma (MM). During maturation, several programmed genetic rearrangements occur increase variation immunoglobulin chains. Class switch recombination (CSR) is one most important among these mechanisms. Germline polymorphisms altering even subtly this play a role etiology and outcome MM. We performed an association study 30 key CSR genes,...
Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with production monoclonal immunoglobulin (M protein) which can be detected in blood and/or urine. lines evidence suggest that genetic factors are involved MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) susceptibility to disease. SNPs within miRNA-binding sites target genes (miRSNPs) may alter strength miRNA-mRNA interactions, thus deregulating...
Cereblon (CRBN) is crucial for antiproliferative and immunomodulatory properties of drugs. The objective this study was to verify whether germline single nucleotide polymorphisms (SNPs) in the CRBN gene may influence response lenalidomide multiple myeloma (MM). Fourteen tagging SNPs covering genetic variability region were genotyped 167 Polish patients with refractory/relapsed MM treated lenalidomide-based regimens. We found that carriers minor alleles two studied rs1714327G > C (OR = 0.26;...
There is overwhelming epidemiologic evidence that the risk of multiple myeloma (MM) has a solid genetic background. Genome-wide association studies (GWAS) have identified 23 loci contribute to susceptibility MM, but low individual penetrance. Combining SNPs in polygenic score (PRS) possible approach improve their usefulness. Using 2361 MM cases and 1415 controls from International Multiple Myeloma rESEarch (IMMEnSE) consortium, we computed weighted an unweighted PRS. We observed associations...
Abstract Gene expression profiling can be used for predicting survival in multiple myeloma (MM) and identifying patients who will benefit from particular types of therapy. Some germline single nucleotide polymorphisms (SNPs) act as quantitative trait loci (eQTLs) showing strong associations with gene levels. We performed an association study to test whether eQTLs genes reported associated prognosis MM are directly measures adverse outcome. Using the genotype‐tissue portal, we identified a...
We evaluated the association between germline genetic variants located within 3'-untranlsated region (polymorphic 3'UTR, ie, p3UTR) of candidate genes involved in multiple myeloma (MM). performed a case-control study International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting 3056 MM patients and 1960 controls recruited from eight countries. selected p3UTR six known to act different pathways relevant pathogenesis, namely KRAS (rs12587 rs7973623), VEGFA (rs10434), SPP1...
Abstract Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome‐wide significant loci shared cancer and noncancer traits. This feature particularly relevant in myeloma (MM) because several susceptibility that have been identified to date are pleiotropic. Therefore, the aim this study was identify novel pleiotropic variants involved MM risk using 28 684 independent nucleotide polymorphisms (SNPs)...
5q minus syndrome is a form of myelodysplastic characterized by the presence an isolated deletion long arm chromosome 5. Patients with respond well to treatment lenalidomide. The JAK2 V617F mutation common feature refractory anemia ring sideroblasts and marked thrombocytosis. Much less known about effectiveness lenalidomide in these patients. We present patient accompanied ringed erythroblasts meeting criteria RARS-T. could identify only two such patients reported literature; no details were...