A5101801489- Salivary Gland Disorders and Functions
- Hematopoietic Stem Cell Transplantation
- Head and Neck Cancer Studies
- Mast cells and histamine
- Salivary Gland Tumors Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Asthma and respiratory diseases
- Hematological disorders and diagnostics
- Chronic Myeloid Leukemia Treatments
- Cancer, Hypoxia, and Metabolism
- Acute Myeloid Leukemia Research
- Oral health in cancer treatment
- Mesenchymal stem cell research
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Macrophage Migration Inhibitory Factor
- Liver physiology and pathology
- Pluripotent Stem Cells Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Proteoglycans and glycosaminoglycans research
- Amyotrophic Lateral Sclerosis Research
- DNA Repair Mechanisms
- COVID-19 Impact on Reproduction
- Tuberous Sclerosis Complex Research
Sheba Medical Center
2003-2024
Tel Aviv University
2013-2024
Technion – Israel Institute of Technology
2004
Hebrew University of Jerusalem
2001-2003
Assaf Harofeh Medical Center
2003
Mayo Clinic
2003
Hadassah Academic College
1996-1998
Rambam Health Care Campus
1995
Hepatic fibrosis is associated with activation of hepatic stellate cells (HSC), the major source extracellular matrix (ECM) proteins. The predominant ECM protein synthesized by HSC collagen type I. We evaluated effect halofuginone—an inhibitor synthesis—on thioacetamide (TAA)–induced liver in rats. In control rats did not express smooth muscle actin, I gene, or tissue metalloproteinases–2 (TIMP–2), suggesting that they were their quiescent state. When treated TAA, livers displayed large...
The mechanisms governing hematopoietic progenitor cell mobilization are not fully understood. We report higher membrane type 1–MMP (MT1-MMP) and lower expression of the MT1-MMP inhibitor, reversion-inducing cysteine-rich protein with Kazal motifs (RECK), on isolated circulating human CD34+ cells compared immature BM cells. correlated clinical in healthy donors patients lymphoid malignancies. Treatment G-CSF further increased decreased RECK murine a PI3K/Akt-dependent manner, resulting...
Abstract Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their roles challenged by CAR-T-cells other immunotherapies. We examined the trends outcomes DLBCL patients undergoing auto-/allo-HSCT between 1990 2021 reported to EBMT. Over this period, 41,148 underwent auto-HSCT, peaking at 1911 cases in 2016, while allo-HSCT saw a maximum of 294 2018. The recent decline...
Patients with graft-versus-host disease (cGVHD) suffer from oral dryness and increased levels of infections mucosal pathologies. The purpose the current study was dual: 1) to investigate salivary functional (sialometry) compositional (sialochemistry) alterations induced by during a 12-month period following onset disease; 2) evaluate effect Salagen 30 mg/d on biochemical immunological composition in cGVHD patients. Significant higher concentrations sodium (Na), magnesium (Mg), total protein...
Stem cell transplantation (SCT)-related salivary gland injury and dysfunction result in local systemic manifestations that may be long lasting are associated with a high rate of morbidity increased risk infection. The antioxidant system have major protective role. We, therefore, assessed capacity function 30 patients who had undergone SCT: 18 males 12 females whose median age was 36 years (range: 7-58). Salivary by sialometric biochemistry means, which included measuring total protein,...
Multiple myeloma (MM) is a malignancy of plasma cells usually infiltrating the bone marrow, associated with production monoclonal immunoglobulin (M protein) which can be detected in blood and/or urine. lines evidence suggest that genetic factors are involved MM pathogenesis, and several studies have identified single nucleotide polymorphisms (SNPs) susceptibility to disease. SNPs within miRNA-binding sites target genes (miRSNPs) may alter strength miRNA-mRNA interactions, thus deregulating...
Major salivary gland dysfunction and severe xerostomia is one of the manifestations graft versus host disease (GVHD). The histopathological evaluation major in patients with GVHD has never been reported. pathological findings submandibular glands a patient who succumbed to are described. Lymphocytic infiltration, parenchymal destruction, fibrosis were observed, which may provide pathophysiological mechanism for hyposalivation observed GVHD.
Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV mainly hepatotrophic but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent transplantation. Both bone marrow (BM) and biopsies Biopsy specimens were stained for hepatitis surface antigen (HB-sAg), aspirates separated all subsets cells. In both cases, DNA analysis detected BM fractions transplantation, recurrence was found only one case. suggest that...
<h3>Background:</h3> Xerostomia is observed in 85% of patients suffering from chronic graft-vs-host disease (cGVHD). The pathophysiological mechanism the major salivary gland dysfunction unclear. <h3>Objective:</h3> To evaluate parotid function a mouse model cGVHD. <h3>Design:</h3> volume, flow rate, lag phase, and composition secreted saliva were assessed mice with cGVHD after pilocarpine stimulation (5mg/kg) by cannulation main excretory duct polyethylene tubing. <h3>Results:</h3>...
RATIONALE Treosulfan is a substance that being studied as part of the conditioning regimen given prior to allogeneic stem cell transplantation in patients with hematological malignancies. It known decompose into 1,2:3,4‐diepoxybutane (DEB) under physiologic conditions. In this study, we investigate whether N ‐terminal valine adducts can be utilized monitor differences DEB formation receiving treosulfan for transplantation. METHODS Blood samples were collected from group 14 transplant...
Background The major salivary glands are target organs affected by acute graft versus host disease (aGVHD), resulting in severe xerostomia. Methods We evaluated the function of an animal model aGVHD (B10.S→SJL/J). For induction aGVHD, SJL/J mice were sublethally irradiated with 900 cGy and injected 2 × 107 splenocytes. that received total-body irradiation (TBI) nonirradiated served as controls. Major gland was vivo at peak (proven both clinically histologically). volume, flow rate,...
Antigen presenting cells (APCs), especially dendritic (DCs), play a major role in the hierarchy of induction immune reactions. DCs are widely accepted as most potent APCs capable inducing protective adaptive responses addition to tolerance self-antigens. The is currently being investigated context many disease and therapeutic settings. In response variety microbial endogenous stimuli, resting peripheral tissues undergo complex maturation process that might involve regulation genes control...