A5001651646- 3D Printing in Biomedical Research
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Hydrogels: synthesis, properties, applications
- Cellular Mechanics and Interactions
- Advanced Materials and Mechanics
- Ultrasound and Cavitation Phenomena
- Innovative Microfluidic and Catalytic Techniques Innovation
- Electrospun Nanofibers in Biomedical Applications
- Enzyme Production and Characterization
- Biofuel production and bioconversion
- Angiogenesis and VEGF in Cancer
- Advanced Drug Delivery Systems
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Ultrasound Imaging and Elastography
- Muscle Physiology and Disorders
- Proteins in Food Systems
- Axon Guidance and Neuronal Signaling
RWTH Aachen University
2022-2025
DWI – Leibniz Institute for Interactive Materials
2022-2025
In this work, a two component microgel assembly using soft anisometric microgels that interlink to create 3D macroporous construct for cell growth is reported. Reactive rods with variable aspect ratio are produced via microfluidics in continuous plug-flow on-chip gelation method by photoinitiated free-radical polymerization of star-polyethylene glycol-acrylate glycidyl methacrylate or 2-aminoethyl comonomers. The resulting complementary epoxy- and amine-functionalized assemble each other...
Microbubbles (MB) are widely used for ultrasound (US) imaging and drug delivery. MB typically spherically shaped, due to surface tension. When heated above their glass transition temperature, polymer-based can be mechanically stretched obtain an anisotropic shape, endowing them with unique features US-mediated blood-brain barrier (BBB) permeation. It is here shown that nonspherical surface-modified BBB-specific targeting ligands, thereby promoting binding sonopermeation of blood vessels in...
Bioprinting is currently the most promising method to biofabricate complex tissues in vitro with potential transform future of organ transplantation and drug discovery. Efforts create such are, however, almost exclusively based on animal-derived materials, like gelatin methacryloyl, which have demonstrated efficacy bioprinting tissues. While these materials are already used clinical applications, uncertainty about their safety still remains due animal origin. Alternatively, synthetic bioinks...
For tissue engineering, nanocellulose-based three-dimensional hydrogel structures hold potential as support material for biomimetic scaffolds to regenerate damaged tissues. Nanocellulose is a natural biocompatible and abundant that can be...
Abstract Microbubbles (MB) are widely used as contrast agents for ultrasound (US) imaging and US‐enhanced drug delivery. Polymeric MB highly suitable these applications because of their acoustic responsiveness, high loading capability, ease surface functionalization. While many studies have focused on using polymeric diagnostic therapeutic purposes, relatively little attention has thus far been paid to improving inherent delivery features. This study here shows that manipulating the polymer...
Gas-filled microbubbles (MB) are routinely used in the clinic as ultrasound contrast agents. MB also increasingly explored drug delivery vehicles based on their stimuli-responsiveness and well-established shell functionalization routes. Broadening range of properties can enhance performance both imaging applications. This be promoted by systematically varying reagents synthesis MB, which case polymeric include surfactants. We therefore set out to study effect key surfactant characteristics,...
Abstract Vasculogenesis and angiogenesis are leveraged by orchestrated secretion of several growth factors. Mimicking this process in vitro can maximize vascularization inside 3D cell cultures. While the role individual factors, such as vascular endothelial factor, Ephrin‐B2, angiopoietins, platelet‐derived factor‐BB (PDGF‐BB) is well studied, temporal influence factor secretion, effect their concentrations combinations on hydrogels, have not been systematically investigated. Here,...
Microgels are water-swollen, crosslinked polymers that widely used as colloidal building blocks in scaffold materials for tissue engineering and regenerative medicine. can be controlled their stiffness, degree of swelling, mesh size depending on polymer architecture, crosslink density, fabrication method-all which influence function interaction with the environment. Currently, there is a lack understanding how composition influences internal structure soft microgels this morphology affects...
Microporous annealed particle (MAP) scaffolds are investigated for their application as injectable 3D constructs in the field of regenerative medicine and tissue repair. While available MAP provide a stable interlinked matrix microgels cell culture, infiltration depth space cells to grow inside is pre-determined by void fraction during assembly. In case fabricated from spherical microgels, cellularity gradient can be observed with highest density on scaffold surface. Additionally, microgel...
By adapting existing bulk gelation protocols to droplet-based microfluidics, polyampholyte poly(dehydroalanine)-based microspheres were fabricated and evaluated regarding biomedical application.
Rod-Shaped Microgels A two-component system consisting of microgel rods creates macroporous interlinked constructs for cell culture in 3D with pores up to several hundreds micrometers. The functionalized that interlink each other aqueous solutions without further additives are produced via microfluidics a continuous plug-flow on-chip gelation method. More details can be found article number 2103554 by Laura De Laporte and co-workers.
Abstract Microgels are water‐swollen, crosslinked polymers that widely used as colloidal building blocks in scaffold materials for tissue engineering and regenerative medicine. can be controlled their stiffness, degree of swelling, mesh size depending on polymer architecture, crosslink density, fabrication method—all which influence function interaction with the environment. Currently, there is a lack understanding how composition influences internal structure soft microgels this morphology...