A5012642762- Bone Tissue Engineering Materials
- Photoacoustic and Ultrasonic Imaging
- Ultrasound and Hyperthermia Applications
- Nanoparticle-Based Drug Delivery
- Ultrasound and Cavitation Phenomena
- Dental Implant Techniques and Outcomes
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
- Spaceflight effects on biology
- Nanoplatforms for cancer theranostics
- Nanocluster Synthesis and Applications
- Lanthanide and Transition Metal Complexes
- Silk-based biomaterials and applications
- Bone health and osteoporosis research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Titanium Alloys Microstructure and Properties
RWTH Aachen University
2023-2025
Universitätsklinikum Aachen
2023-2025
Iran University of Medical Sciences
2022-2024
Amirkabir University of Technology
2012-2024
Gadolinium-based contrast agents (GBCAs) are commonly used in magnetic resonance imaging (MRI). Concerns about the retention of gadolinium body and its potential toxicity have highlighted need for detection methods to monitor urinary excretion after MRI procedures. This study presents a fluorescence-enhanced assay detecting GBCAs urine using gold nanoparticles (AuNPs) functionalized with chelator [3,4,3-LI(1,2-HOPO)] europium, which together act as fluorophore. The higher binding affinity...
Transplantation of demineralized bone matrix and simultaneous periodic magnetic field stimulation enhances regeneration in critically sized injury rat animal models.
Microbubbles (MB) are widely used for ultrasound (US) imaging and drug delivery. MB typically spherically shaped, due to surface tension. When heated above their glass transition temperature, polymer-based can be mechanically stretched obtain an anisotropic shape, endowing them with unique features US-mediated blood-brain barrier (BBB) permeation. It is here shown that nonspherical surface-modified BBB-specific targeting ligands, thereby promoting binding sonopermeation of blood vessels in...
Abstract In this study, double diffusion method in a physiologically relevant environment was used to prepare biomimetic gelatin‐amorphous calcium phosphate nanocomposite scaffold. The precipitated within gelatin as well produced scaffolds were characterized by the commonly bulk techniques. results showed that porous with three‐dimensionally interconnected microstructure, pore size ranging from 150 350 μm. Porosity about 82% and nanocrystalline minerals dispersed evenly among fibers. A...
Abstract Microbubbles (MB) are widely used as contrast agents for ultrasound (US) imaging and US‐enhanced drug delivery. Polymeric MB highly suitable these applications because of their acoustic responsiveness, high loading capability, ease surface functionalization. While many studies have focused on using polymeric diagnostic therapeutic purposes, relatively little attention has thus far been paid to improving inherent delivery features. This study here shows that manipulating the polymer...
The combination of polymeric PBCA microbubbles and highly hydrophobic metal phthalocyanines provides bimodal ultrasound/photoacoustic imaging capabilities based on the high encapsulation efficiencies tunable optical properties latter.
While bone regenerates itself after an injury, a critical defect requires external interventions. Engineering approaches to restore provide temporary scaffold support the damage and beneficial biological cues for repair. Biomimetically generated scaffolds replicate naturally occurring phenomena in regeneration. In this study, gelatin-calcium phosphate nanocomposite was synthesized by efficient cost-effective double-diffusion biomimetic approach. Calcium ions are impregnated gelatin,...
Glioblastoma multiforme (GBM) is a common, aggressive, fast-growing tumor of the central nervous system that currently has no effective treatment. Although stem cell therapy shown promising in vitro achievements, blood-brain barrier (BBB) always been major hurdle to clinical success. To overcome this challenge, exosomes have targeted as attractive drug delivery agents numerous studies since they are small enough enter BBB. Furthermore, exosomes' characteristics and compositions directly...
Mineralization of gelatin electrospun nano and micro fiber was investigated in order to prepare a biomimetic bone nanocomposite. For this aim, at first, calcium containing nanofibers were by novel ethanol/water/salt solution. Fibers with mean diameters varying from 300 3000 nm acquired. Then, mats exposed phosphate ions soaking them solution or laminating between films. SEM micrographs demonstrated the presence sized minerals on fibers. FTIR XRD results illustrated that phosphates all...