- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Angiogenesis and VEGF in Cancer
- Esophageal and GI Pathology
Amsterdam University Medical Centers
2020-2024
University of Amsterdam
2020-2024
Cancer Center Amsterdam
2022
Neoadjuvant chemoradiotherapy (nCRT) improves outcomes in resectable esophageal adenocarcinoma (EAC), but acquired resistance precludes long-term efficacy. Here, we delineate these mechanisms. RNA sequencing on matched patient samples obtained pre-and post-neoadjuvant treatment reveal that oxidative phosphorylation was the most upregulated of all biological programs following nCRT. Analysis patient-derived models confirms mitochondrial content and oxygen consumption strongly increase...
Abstract Background This study evaluated the association of pathological tumour response (tumour regression grade, TRG) and a novel scoring system, combining both TRG nodal status (TRG-ypN score; TRG1-ypN0, TRG>1-ypN0, TRG1-ypN+ TRG>1-ypN+), with recurrence patterns survival after multimodal treatment oesophageal adenocarcinoma. Methods Dutch nationwide cohort included patients treated neoadjuvant chemoradiotherapy followed by oesophagectomy for distal or gastro-oesophageal...
Long-term anti-angiogenesis leads to pruned vasculature, densely deposited extracellular matrix (ECM), and consequently reduced chemotherapy delivery in esophagogastric cancer (EGC). To address this issue, we evaluated the efficacy of adding a hyaluronidase or NO-donor regimen anti-angiogenic drugs.
Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. stellate cells (PSC) are activated hypoxia promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed explore how interact contribute invasive growth in PDAC. [18F]HX4 PET/CT was found be feasible non-invasive method assess tumor 42 patients correlated with HIF1α immunohistochemistry matched surgical specimens. uptake were strong prognostic markers for...