Dajia Liu

ORCID: 0000-0002-1407-7370
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Cancer Cells and Metastasis
  • Esophageal Cancer Research and Treatment
  • Gastric Cancer Management and Outcomes
  • Cancer, Hypoxia, and Metabolism
  • Pancreatic and Hepatic Oncology Research
  • Cancer Treatment and Pharmacology
  • Angiogenesis and VEGF in Cancer
  • Esophageal and GI Pathology

Amsterdam University Medical Centers
2020-2024

University of Amsterdam
2020-2024

Cancer Center Amsterdam
2022

Neoadjuvant chemoradiotherapy (nCRT) improves outcomes in resectable esophageal adenocarcinoma (EAC), but acquired resistance precludes long-term efficacy. Here, we delineate these mechanisms. RNA sequencing on matched patient samples obtained pre-and post-neoadjuvant treatment reveal that oxidative phosphorylation was the most upregulated of all biological programs following nCRT. Analysis patient-derived models confirms mitochondrial content and oxygen consumption strongly increase...

10.1016/j.xcrm.2022.100802 article EN cc-by-nc-nd Cell Reports Medicine 2022-11-01

Abstract Background This study evaluated the association of pathological tumour response (tumour regression grade, TRG) and a novel scoring system, combining both TRG nodal status (TRG-ypN score; TRG1-ypN0, TRG>1-ypN0, TRG1-ypN+ TRG>1-ypN+), with recurrence patterns survival after multimodal treatment oesophageal adenocarcinoma. Methods Dutch nationwide cohort included patients treated neoadjuvant chemoradiotherapy followed by oesophagectomy for distal or gastro-oesophageal...

10.1093/bjs/znae034 article EN cc-by British journal of surgery 2024-01-31

Long-term anti-angiogenesis leads to pruned vasculature, densely deposited extracellular matrix (ECM), and consequently reduced chemotherapy delivery in esophagogastric cancer (EGC). To address this issue, we evaluated the efficacy of adding a hyaluronidase or NO-donor regimen anti-angiogenic drugs.

10.1016/j.biopha.2024.117261 article EN cc-by-nc-nd Biomedicine & Pharmacotherapy 2024-08-05

Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and a hypoxic microenvironment. stellate cells (PSC) are activated hypoxia promote excessive desmoplasia, further contributing to the development of hypoxia. We aimed explore how interact contribute invasive growth in PDAC. [18F]HX4 PET/CT was found be feasible non-invasive method assess tumor 42 patients correlated with HIF1α immunohistochemistry matched surgical specimens. uptake were strong prognostic markers for...

10.3390/biomedicines8110444 article EN cc-by Biomedicines 2020-10-22
Coming Soon ...