A5010862359- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Evacuation and Crowd Dynamics
- Surface Roughness and Optical Measurements
- Fire dynamics and safety research
- Crystallography and molecular interactions
- Synthesis and Reactivity of Heterocycles
- Studies on Chitinases and Chitosanases
- Laser Material Processing Techniques
- Computational Drug Discovery Methods
- Insect Pest Control Strategies
- Wheat and Barley Genetics and Pathology
- CCD and CMOS Imaging Sensors
- Structural Health Monitoring Techniques
- Cancer therapeutics and mechanisms
- Fire Detection and Safety Systems
- Advanced Chemical Sensor Technologies
- Plant Pathogens and Fungal Diseases
- Insect symbiosis and bacterial influences
- Piperaceae Chemical and Biological Studies
- Photonic Crystal and Fiber Optics
- Aerogels and thermal insulation
- Insect Pheromone Research and Control
- Advanced Fiber Optic Sensors
- Geological and Geophysical Studies
Dalian University
2021-2025
Dalian University of Technology
2021-2025
Tsinghua University
2004-2024
Tianjin University
2024
East China University of Science and Technology
2024
Chinese Academy of Agricultural Sciences
2023-2024
Institute of Plant Protection
2023-2024
Peking University
2023
Peking University Cancer Hospital
2023
Ministry of Agriculture and Rural Affairs
2023
Understanding the biological functions of Puccinia striiformis f. sp. tritici ( Pst ) effectors is fundamental for uncovering mechanisms pathogenicity and variability, thereby paving way developing durable effective control strategies stripe rust. However, due to lack an efficient genetic transformation system in , progress effector function studies has been slow. Here, we modeled structures 15,201 from twelve races or isolates, a isolate, one hordei isolate using AlphaFold2. Of these, 8,102...
The insect chitinase OfChtI from the agricultural pest Ostrinia furnacalis (Asian corn borer) is a promising target for green insecticide design. critical chitinolytic enzyme cuticular chitin degradation at stage of molting. In this study, piperine, natural amide compound isolated black pepper, Piper nigrum L., was discovered first time to have inhibitory activity toward OfChtI. compound–enzyme interaction presumed take place between piperine benzo[d][1,3] dioxole skeleton and subsite −1...
Abstract Integrating advantages of automated driving and mass transport, autonomous buses have broad development prospects. The research on the public acceptance will help to provide a basis for formulating policies measures, thus important theoretical practical significance. In this paper, an initial model was established. An on‐line survey conducted with total 401 valid samples collected. reliability validity tests data showed that internal consistency questionnaire high, all met...
Insect pest chitinases are potential target for developing new insect growth regulators. Piperine was found first to inhibit the chitinase (OfChi-h) from Ostrinia furnacalis (Asian corn borer) in this work, except previously reported OfChtI. Novel piperonyl-tethered rhodanine derivatives 7a-j were rationally designed with piperine as lead and synthesized by introducing a unique moiety into scaffold based on similar binding cavity of OfChtI OfChi-h. Compared piperine, compounds showed...
A series of novel aminopyridyl/pyrazinyl-substituted spiro[indoline-3,4'-piperidine]-2-ones were designed, synthesized, and tested in various vitro/in vivo pharmacological antitumor assays. 6-[6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridyl]-1'-methylspiro[indoline-3,4'-piperidine]-2-one (compound 5b or SMU-B) was identified as a potent, highly selective, well-tolerated, orally efficacious c-Met/ALK dual inhibitor, which showed pharmacodynamics effect by inhibiting c-Met...
The heat insulation ability and thermal stability of protection materials play extremely important role in the aero-engines under high temperature. Herein, we design carbon-SiO2-Al2O3 (CSA) composite aerogel through thermochemical restructuring from phenol-formaldehyde resin-SiO2-Al2O3 (PSA) aerogel. This restructured not only shows better adhesion property room temperature but also possesses higher desirable Taking PSA-0.5 as an example, compressive strain-stress test unveils that it can be...
The application of some reported inhibitors against the chitinolytic enzyme Of ChtI was limited due to their unsatisfactory insecticidal activities. Hence, we first performed a synergetic design strategy combining π-stacking effect with aqueous solubility find novel rhodanine analogues inhibitory activities ChtI. Novel compounds IAa–f and IBa–f have weak solubility, but they (IAd: Ki = 4.0 μM; IBd: 2.2 μM) showed better comparable efficiency toward Ostrinia furnacalis compared high IIAa–f...
Harmine (HAM) is a natural product with neuroprotective and antitumor activity. Its poor aqueous solubility the major factor limiting its clinical application. In this work, seven new organic acid salts of HAM were prepared systematically characterized. Their single crystals obtained, structures identified by single-crystal X-ray diffractometer. The corresponding solubilities in water determined temperature range 20–35 °C HPLC method. All showed significantly improved powder profiles...
A decentralized inverse approach based on Bayesian inference and Markov Chain Monte Carlo sampling is developed to estimate the location intensity of building fires. Compared with methods only sensor data or fire models, this has little limits complexity structures can be performed in real time due combination those two methods. Additionally, by dividing into several zones, each which capable inversion its local reading and/or together neighbor readings, algorithm more efficient robust...
Singlet oxygen is a short half-life cytotoxic agent which can be generated by chemical and photochemical methods. In order to make use of its antibacterial action at selected location, it desirable have singlet in relatively stable, "caged" structure, the form an endoperoxide. Here, trimethylsilyl (TMS) group supplies steric bulk, inhibiting cycloreversion reaction produce very little under ambient conditions. However, when fluoride ions are added as tetrabutylammonium fluoride, rapid...
Understanding the biological functions of Puccinia striiformis f. sp. tritici (Pst) effectors is fundamental for uncovering mechanisms pathogenicity and variability, thereby paving way developing durable effective control strategies stripe rust. However, due to lack an efficient genetic transformation system in Pst, progress effector function studies has been slow. Here, we modeled structures 15,201 from twelve Pst races or isolates, a isolate, one hordei isolate using AlphaFold2. Of these,...
A cantilever beam with a breathing crack is studied to improve the identification sensitivity by parametric optimization of sample entropy and wavelet transformation. Crack special bi-linear phenomenon experienced fatigue cracks which are under dynamic loadings. Entropy measure, can quantify complexity or irregularity in system dynamics, hence employed bi-linearity/irregularity vibration response, induced crack. To measurement for identification, transformation merged entropy. The different...
Prediction of protein secondary structure from the amino acid sequence is a classical bioinformatics problem in computational biology. For accurate predicting sequence-structure mapping relationship between and features, novel deep learning prediction model proposed by combining convolutional neural network (CNN) bi-directional recurrent (BRNN) with long short-term memory cells (Bi-directional LSTM RNN). In order to draw eight classes (Q8) results, we first utilize CNN filter sample...
One prototype carbon fiber-reinforced plastics (CFRP) panel for 5-m Dome A Terahertz Explorer antenna is replicated successfully in meeting the surface accuracy requirement of less than 10 μm rms by using resin-rich layer technology. By considering unconventional thermal deformation behavior a composite structure, finite-element model (FEM) produced to predict at low temperature. Effects structural parameters on are discussed and they used design optimization minimizing error An experimental...