A5080257366- Adipose Tissue and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Rabbits: Nutrition, Reproduction, Health
- Regulation of Appetite and Obesity
- Ovarian cancer diagnosis and treatment
- Appendicitis Diagnosis and Management
- Protein Hydrolysis and Bioactive Peptides
- Endometriosis Research and Treatment
- Reproductive Physiology in Livestock
- Molecular Biology Techniques and Applications
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
- Reproductive System and Pregnancy
- Spectroscopy Techniques in Biomedical and Chemical Research
- Animal Genetics and Reproduction
- Electron and X-Ray Spectroscopy Techniques
- bioluminescence and chemiluminescence research
- RNA and protein synthesis mechanisms
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Muscle Physiology and Disorders
Université Paris-Saclay
2018-2024
Biologie de la Reproduction, Environnement, Epigénétique et Développement
2020-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2019-2024
Université de Versailles Saint-Quentin-en-Yvelines
2020-2024
École Nationale Vétérinaire d'Alfort
2019-2024
Centre Île-de-France - Jouy-en-Josas - Antony
2020-2021
Laboratoire de Biologie du Développement
2017-2019
Génétique Animale et Biologie Intégrative
2015-2019
Physiologie de la Reproduction et des Comportements
2015
Abstract Background Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is an innovative treatment against peritoneal carcinomatosis. Doxorubicin a common intra-venous chemotherapy used for carcinomatosis and PIPAC. This study evaluated the impact of increased PIPAC intraperitoneal pressure on distribution cell penetration doxorubicin in sheep model. Methods was aerosolized using into cavity 6 ewes (pre-alpes breed): N = 3 with 12 mmHg (“group 12”) 20 20”). Samples from peritoneum (...
Lactation is an essential process for mammals. In sheep, the R96C mutation in suppressor of cytokine signaling 2 (SOCS2) protein associated with greater milk production and increased mastitis sensitivity. To shed light on involvement mammary gland development lactation, we developed a mouse model carrying this (SOCS2KI/KI). Mammary glands from virgin adult SOCS2KI/KI mice presented branching defect less epithelial tissue, which were not compensated later stages development. cell (MEC)...
During the first cell cycles of early development, chromatin embryo is highly reprogrammed while embryonic genome starts its own transcription. The spatial organization an important process that contributes to regulating gene transcription in time and space. It has, however, been poorly studied context embryos. To study cause-and-effect link between embryos, we focused on ribosomal genes, which are silent initially but start be transcribed 2-cell mouse We demonstrated sequences unprocessed...
Alterations to the metabolic endocrine environment during early life are crucial mammary gland development. Among these environmental parameters, initial nutritional event after birth is consumption of milk, which represents first maternal support provided mammalian newborns. Milk a complex fluid that exerts effects far beyond its immediate value. The present study, therefore, aimed determine effect changes neonatal and prepubertal periods on adult phenotype. Newborn rabbits were suckled by...
Summary The tubular shape of mitochondrial cristae depends upon a specific composition the inner membrane, including cardiolipin that allows strong curvature and promotes optimal organization ATP synthase. Here we identify Hacd1, which encodes an enzyme involved in very long chain fatty acid biosynthesis, as key regulator composition, structure functional properties membranes muscle. In Hacd1 -deficient mice, reduced content was associated with dilation caused defective phosphorylating...
Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, physical activity. However, whether skeletal can be oriented or not during early embryonic stages never been investigated. Here, we report that pyruvate as the only source of carbohydrate in culture medium mouse one cell stage embryo establishment muscular adulthood. We found alone induced changes contractile sexually dependent manner. For male mice, switch to more...
Abstract Background:Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is an innovative treatment against peritoneal carcinomatosis. Doxorubicin a common intra-venous chemotherapy used for carcinomatosis and PIPAC. This study evaluated the impact of increased PIPAC intraperitoneal pressure on distribution cell penetration doxorubicin in sheep model.Methods: was aerosolized using into cavity 6 ewes (pre-alpes breed): N=3 with 12mmHg (group 1) 20mmHg 2). Samples from peritoneum (N=6),...
Abstract During the first cell cycles of early development, chromatin embryo is highly reprogrammed alongside that embryonic genome starts its own transcription. The spatial organization a major process contributes to regulating gene transcription in time and space, however, it poorly studied context embryos. To study cause effect link between embryos, we focused on ribosomal genes, are silent begin transcribe during 2-cell stage mouse. We demonstrated sequences spatially organized very...
Abstract Background Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is an innovative treatment against peritoneal carcinomatosis. Doxorubicin a common intra-venous chemotherapy used for carcinomatosis and PIPAC. This study evaluated the impact of increased PIPAC intraperitoneal pressure on distribution cell penetration doxorubicin in sheep model. Methods was aerosolized using into cavity 6 ewes: N=3 with 12mmHg (group 1) 20mmHg 2). Samples from peritoneum (N=6), ovarian (N=1),...