A5063811482- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Evolution and Genetic Dynamics
- RNA modifications and cancer
- Inflammasome and immune disorders
- Pomegranate: compositions and health benefits
- MicroRNA in disease regulation
- Gene Regulatory Network Analysis
- stochastic dynamics and bifurcation
- Paraoxonase enzyme and polymorphisms
- RNA Research and Splicing
- Ferroptosis and cancer prognosis
- Medicinal Plants and Bioactive Compounds
- Treatment of Major Depression
- Axon Guidance and Neuronal Signaling
- Body Image and Dysmorphia Studies
- Identity, Memory, and Therapy
- Apelin-related biomedical research
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Obsessive-Compulsive Spectrum Disorders
Wuhan University
2013-2025
Renmin Hospital of Wuhan University
2018-2025
Jilin University
2016-2022
Claudin-6 (CLDN6), a member of claudin transmembrane protein family, has recently been reported to be undetectable or at low levels in human breast cancer cell lines and tissues plays role suppression migration invasion cells. In addition, it is that CLDN6 expression regulated by DNA methylation various cancers lines. However, unclear how regulates expression. Here we show the mechanism which line MCF-7.RT-PCR, Western blot immunofluorescent staining were utilized investigate MCF-7...
Polycomb Repressive Complex 2 (PRC2) catalyzes histone methylation at H3 Lys27, and plays crucial roles during development diseases in numerous systems. Its catalytic subunit EZH2 represents a key nuclear target for long non-coding RNAs (lncRNAs) that emerging to be novel class of epigenetic regulator participate diverse cellular processes. LncRNAs are characterized by high tissue-specificity; however, little is known about the tissue profile EZH2- interacting lncRNAs.Here we performed...
Background: Coronavirus disease-19 (Covid-19) is one of the most devastating epidemics in 21st century, which has caused considerable damage to physical and mental health human beings. Despite a few regions like China having controlled epidemic trends, countries are still under siege COVID-19. As emphasis on cleaning hygiene been increasing, problems related obsessive-compulsive disorder (OCD) may appear. Objective: This study was designed investigate prevalence OCD urban population Wuhan...
Abstract Background Major depressive disorder (MDD) is a common mental illness that affects millions of people worldwide and imposes heavy burden on individuals, families society. Previous studies MDD predominantly focused neurons employed bulk homogenates brain tissues. This paper aims to decipher the relationship between oligodendrocyte lineage (OL) development at single-cell resolution level. Methods Here, we present use guided regularized random forest (GRRF) algorithm explore...
Social withdrawal in patients with depression can aggravate depressive symptoms. However, few studies focus on the behavioral changes of social isolation after CUMS. NRF2 had been reported to be down-regulated But whether participates induced by CUMS remains unclear. This study aims develop a new model combined CUMS, and investigate such are related signaling.This included two stages. In Stage 1, rats were subjected 4-week CUMS-susceptible selected. 2, received or support. Behavioral tests...
Resveratrol, a plant-derived polyphenol, exhibits significant antidepressant effects and notably enhances neuroplasticity in neurological diseases. However, whether the function of resveratrol is related to remains uncertain, underlying mechanisms poorly understood. This study aims investigate role mechanism depression. Here, we adopted chronic unpredictable mild stress (CUMS) model intervention by oral gavage. Thereafter, behavioral tests confirmed resveratrol’s effect, Nissl staining,...
Resveratrol, a natural bitter polyphenol, exhibits significant antidepressant property. Numerous studies have linked its effect to neuroplasticity enhancement or mitochondrial regulation. However, the interplay between these two mechanisms remains unclear. This study aims elucidate relationship among resveratrol's effect, regulatory impact on and function, investigate potential role of type 2 taste receptors (Tas2rs) in processes. A chronic unpredictable mild stress (CUMS) model was used...
Cognitive impairment in schizophrenia occurs the early stages of disease and is closely associated with prognosis. Alleviation cognitive faces major challenges owing to lack preventive therapeutic drugs that are novel effective. Urolithin A (UA) a gut microbial metabolite ellagic acid has demonstrated neuroprotective effects multiple neurological models. Nonetheless, neuromodulatory role UA yet be elucidated. Wistar rat pups were separated from their mothers for 24 h on postnatal days (PNDs)...
Endoplasmic reticulum (ER) stress participates in the occurrence and development of depression, but underlying mechanism is not fully understood. This study aimed to investigate behavioral performance intracerebral molecular changes an ER model male rats. Intrahippocampal injection tunicamycin (TM) was performed on rats as a stress. The body weight determined, tests, including sucrose preference test (SPT), open field (OFT), forced swimming (FST), were evaluate depressive anxiety-like...
Claudin-6 (CLDN6) is an integral component of the tight junction proteins in polarized epithelial and endothelial cells plays a crucial role maintaining cell integrity. Deregulation CLDN6 expression distribution tumor tissues have been widely documented correlated with cancer progression metastasis. However, complete mechanistic understanding regulation function remains to be studied. Herein, we show new potential properties functions from bioinformatics analysis. Using numerous algorithms...
Major depressive disorder (MDD) is a mental illness with high incidence and complex etiology, that poses serious threat to human health increases the socioeconomic burden. Currently, high-accuracy biomarkers for MDD diagnosis are urgently needed. This paper aims identify novel blood-based diagnostic MDD. Whole blood DNA methylation data gene expression from Gene Expression Omnibus database downloaded. Then, differentially expressed/methylated genes (DEGs/DMGs) identified. In addition, we...
Background: Far from being a clinical disease, the COVID-19 pandemic has become threatening social event worldwide exerting long-term impacts on human beings. Objective: This study was designed to determine if and what extent psychiatric inpatients during remission phase of suffered vicarious traumatization. Method: Totally 266 eligible participants psychological wards in hospital were recruited October 26th, 2020 February 4th, 2021 finish self-made online questionnaire consisting Impact...
This paper addresses the stability problem of genetic regulatory networks by involving spatial diffusion concentration, discrete and infinite distributed delays. By using theories partial differential equation Lyapunov stability, global exponential criteria in algebraic form are derived for reaction (RDGRNs) with The conditions simple can be directly calculated parameters networks. Moreover, theoretical results universal applied to deal RDGRNs or without Eventually, validity feasibility...