A5073341190- Chemical Safety and Risk Management
- Air Quality and Health Impacts
- Occupational Health and Safety Research
- Epilepsy research and treatment
- Indoor Air Quality and Microbial Exposure
- Infection Control and Ventilation
- Safe Handling of Antineoplastic Drugs
- Risk and Safety Analysis
- Genetics and Neurodevelopmental Disorders
- Oil Spill Detection and Mitigation
- Scientific Measurement and Uncertainty Evaluation
- Pharmaceutical studies and practices
- Glycogen Storage Diseases and Myoclonus
- Nuclear and radioactivity studies
- Fault Detection and Control Systems
- Glioma Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Neuroscience and Neuropharmacology Research
- Air Quality Monitoring and Forecasting
- Electromagnetic Compatibility and Measurements
- Delphi Technique in Research
- Contact Dermatitis and Allergies
- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Building Energy and Comfort Optimization
University of Minnesota
2015-2024
Minnesota Department of Health
2021-2024
Federal Institute for Risk Assessment
2024
University of Kansas
2024
Vilnius University
2024
The University of Texas Southwestern Medical Center
2015-2023
Greater Baltimore Medical Center
2022-2023
Twin Cities Orthopedics
2021
Center for Environmental Health
2013-2020
University of California, Los Angeles
2019
Vadadustat is an oral hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitor, a class of drugs that stabilize HIF and stimulate erythropoietin red-cell production.
Poor air quality is a leading contributor to the global disease burden and total number of deaths worldwide. Humans spend most their time in built environments where majority inhalation exposure occurs. Indoor Air Quality (IAQ) challenged by outdoor pollution entering indoors through ventilation infiltration indoor emission sources. The aim this study was understand current knowledge level gaps regarding effective approaches improve IAQ. Emission regulations currently focus on emissions,...
Clinical genomic tests that examine the DNA sequence of large numbers genes are commonly used in diagnosis and management epilepsy pediatric patients. The permanence test result interpretations is not known.To investigate value reinterpreting previously reported results.This study retrospectively reviewed reinterpreted results from July 1, 2012, to August 31, 2015, for patients who underwent testing at a single tertiary care health facility. Reinterpretation variants was conducted May...
Background Programmed cell death receptor-1 (PD-1)-blocking antibodies are approved to treat metastatic or locally advanced cutaneous squamous carcinoma (CSCC) cases ineligible for curative surgery radiation. Notwithstanding, some patients experience inadequate responses severe immune-related adverse events (AEs), indicating the need improved therapies. Cosibelimab is a high-affinity programmed death-ligand 1 (PD-L1)-blocking antibody that activates innate and adaptive immunity by blocking...
Abstract To understand the apparently paradoxical appearance of phosphorylase in muscle cultured from patients with McArdle disease, enzyme culture was studied immunologically and electrophoretically. Antibody against normal human completely inhibited activity adult muscle, but it had no effect on cultures individuals or disease. Also, amounts antibody that would inhibit mature left about 30% obtained fetus at four months' gestation. Acrylamide‐disc slab‐gel electrophoresis showed a single...
Abstract The GuLF STUDY, initiated by the National Institute of Environmental Health Sciences, is investigating health effects among workers involved in oil spill response and clean-up (OSRC) after Deepwater Horizon (DWH) explosion April 2010 Gulf Mexico. Clean-up included situ burning on water surface flaring gas captured near seabed brought to surface. We estimated emissions PM2.5 related pollutants resulting from these activities, as well engines vessels working OSRC. ranged 30 1.33e6 kg...
The GuLF Study is investigating adverse health effects from work on the response and clean-up after Deepwater Horizon explosion oil release. An essential necessary component of that study was exposure assessment. Bayesian statistical methods over 135 000 measurements total hydrocarbons (THC), benzene, ethylbenzene, toluene, xylene, n-hexane (BTEX-H) were used to estimate inhalation exposures these chemicals for >3400 groups (EGs) formed three determinants: job/activity/task, location, time...
On 20 October 2020, the Working Group “Exposure Models” of Europe Regional Chapter International Society Exposure Science (ISES Europe) organised an online workshop to discuss theoretical background models for assessment occupational exposure chemicals. In this report, participants with active role before and during summarise most relevant discussion points conclusions well-attended workshop. ISES has identified modelling as one priority area strategic development science in coming years....
Children with cerebral palsy who receive selective dorsal rhizotomy (SDR) for treatment of spasticity may show suprasegmental changes in upper limb function and control speech musculature. Anecdotal reports suggest that effects extend to cognitive functions such as attention language. This study examined the performance 16 children spastic diplegic on tests visual other 1 day prior 6 months following SDR. undergoing SDR were compared 9 diplegia, matched severity amount therapy, did not SDR,...
The Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation requires the establishment Conditions Use (CoU) for all exposure scenarios to ensure good communication safe working practices. Setting CoU risk assessment relevant Contributing Scenarios (CSs) in scenario. A new CS has be created whenever an Operational Condition (OC) is changed, resulting excessive number assessments. An efficient solution quantify OC concentrations identify reasonable worst-case...
Exposure judgments made without personal exposure data and based instead on subjective inputs tend to underestimate exposure, with judgment accuracy not significantly more accurate than random chance. Therefore, objective that contribute decision making are needed. Models have been shown anecdotally be useful in accurately predicting but their use occupational hygiene has limited. This may attributable a general lack of guidance model selection scant input data. The systematic evaluation the...
Drawing appropriate conclusions about a scenario for which the exposure is truly unacceptable drives and risk management, protects health safety of those individuals. To ensure vast majority these decisions are accurate, must be based upon proven approaches tools. When solely on professional judgment guided by subjective inputs, however, they more than likely wrong, biased, underestimating true exposure. Models have been shown anecdotally to useful in accurately predicting but their use...
The April 2010 Deepwater Horizon drilling unit explosion at the Macondo oil well resulted in release of approximately 779 million l into Gulf Mexico. As part response effort to break up slicks on water's surface, 6.81 chemical dispersants COREXIT™ EC9500A and EC9527A were applied by plane or vessel injected near seabed. GuLF Long-term Follow-up Study is investigating possible adverse health effects workers involved spill clean-up (OSRC). In this paper, we describe potential...
Most exposure assessments are conducted without the aid of robust personal data and based instead on qualitative inputs such as education experience, training, documentation process chemicals, tasks equipment, other information. Qualitative determine whether there is any follow-up, influence type that occurs, quantitative sampling, worker implementing risk management measures. Accurate judgments ensure appropriate follow-up in turn ensures management. Studies suggest judgment accuracy low. A...