A5100430920- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Endoplasmic Reticulum Stress and Disease
- Plant nutrient uptake and metabolism
- Plant responses to water stress
- Plant Molecular Biology Research
- Cytokine Signaling Pathways and Interactions
- Peroxisome Proliferator-Activated Receptors
- Coronary Interventions and Diagnostics
- Gestational Diabetes Research and Management
- NF-κB Signaling Pathways
- Cardiac Imaging and Diagnostics
- Digestive system and related health
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Nutrition, Health and Food Behavior
- Pancreatic function and diabetes
- Natural product bioactivities and synthesis
- Mechanisms of cancer metastasis
- Diverse Approaches in Healthcare and Education Studies
- MicroRNA in disease regulation
- Phytochemistry and Biological Activities
- Health and Wellbeing Research
- Cardiac Arrhythmias and Treatments
CHA University
2021-2025
University of California, Los Angeles
2015-2019
Chonnam National University Hospital
2014
Ajou University
2003
The RNA-directed DNA methylation (RdDM) pathway in plants controls gene expression via cytosine methylation. ability to manipulate RdDM would shed light on the mechanisms and applications of control expression. Here, we identified diverse proteins that are capable targeting silencing Arabidopsis when tethered an artificial zinc finger (ZF-RdDM). We studied their order action within by testing target different mutants. also evaluated ectopic siRNA biogenesis, RNA polymerase V (Pol V)...
Background/Aims: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in hepatic fibrogenesis and liver repair chronic disease.Our research highlights the antifibrotic potential of placenta-derived mesenchymal stem cells (PD-MSCs) phosphatase regenerating liver-1 (PRL-1) promoting regeneration. Methods:We evaluated efficacy PD-MSCs overexpressing PRL-1 (PD-MSCs ) bile duct ligation (BDL)-induced rat injury model, focusing on their ability to regulate EMT.Results: significantly...
Abstract Background Cholesterol accumulation and calcium depletion induce hepatic injury via the endoplasmic reticulum (ER) stress response. ER regulates imbalance between mitochondria. We previously reported that phosphatase of regenerating liver-1 (PRL-1)-overexpressing placenta-derived mesenchymal stem cells (PD-MSCs PRL−1 ) promoted liver regeneration mitochondrial dynamics in a cirrhotic rat model. However, role PRL-1 stress-dependent is not clear. Therefore, we demonstrated PD-MSCs...
Hexapeptide WKYMVm (Trp-Lys-Tyr-Met-Val-D-Met), a ligand of formyl peptide receptor 2, exhibits anti-inflammatory and angiogenic properties in disease models. However, the therapeutic effects on hepatic fibrosis have not been evaluated to date. Therefore, we investigated whether exerts antifibrotic induces vascular regeneration rat model bile duct ligation (BDL). The liver BDL were analyzed using biochemical assays, qRT-PCR, western blotting, immunofluorescence, immunohistochemistry. To...
Epicardial ablation is necessary for the treatment of ventricular tachycardias refractory to endocardial due arrhythmic substrates involving epicardium. The human epicardium composed adipose tissue and coronary vasculature embedded on surface within myocardium, which can complicate electroanatomical mapping, electrogram interpretation delivery. We propose using near-infrared spectroscopy (NIRS) decipher from myocardial hearts ex vivo . Histological measurement epicardial thickness direct...
Abstract Background: Accumulation of cholesterol and depletion calcium induce hepatic injury through the endoplasmic reticulum (ER) stress response. ER regulates imbalance between mitochondria. Previously, we reported that phosphatase regenerating liver-1 (PRL-1)-overexpressing placenta-derived mesenchymal stem cells (PD-MSCs PRL-1 ) promoted liver regeneration mitochondrial dynamics in a cirrhotic rat model. However, whether is involved stress-dependent unclear. So, demonstrated PD-MSCs...