A5033731281- Bone and Dental Protein Studies
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Wnt/β-catenin signaling in development and cancer
- Protease and Inhibitor Mechanisms
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Genomics and Chromatin Dynamics
- Ear Surgery and Otitis Media
- DNA Repair Mechanisms
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Immune cells in cancer
- Blood Coagulation and Thrombosis Mechanisms
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial metabolism and enzyme function
- Nanoparticle-Based Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
- Hearing, Cochlea, Tinnitus, Genetics
- CRISPR and Genetic Engineering
IBSA Farmaceutici (Italy)
2024
Dompé (Italy)
2022-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2013-2023
Farmaceutici Damor (Italy)
2022
University of Copenhagen
2017-2021
University of Louisville
2013
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013
Weizmann Institute of Science
2013
Abstract Purpose: Carcinoma cells enhance their invasive capacity through dedifferentiation and dissolution of intercellular adhesions. A key activator this process is the ZEB1 transcription factor, which induced in invading cancer by canonical Wnt signaling (β-catenin/TCF4). Tumor invasiveness also entails proteolytic remodeling peritumoral stroma. This study aimed to investigate potential regulation plasminogen system constituted urokinase (uPA), its inhibitor, inhibitor-1 (PAI-1)....
The eukaryotic genome is organized in a three-dimensional structure called chromatin, constituted by DNA and associated proteins, the majority of which are histones. Post-translational modifications histone proteins greatly influence chromatin regulate many DNA-based biological processes. Methylation lysine 36 3 (H3K36) post-translational modification functionally relevant during early steps damage repair. Here, we show that JMJD-5 regulates H3K36 di-methylation it required at late stages...
Chemotherapy-induced peripheral neuropathy (CIPN) and hypersensitivity reactions (HSRs) are among the most frequent impairing side effects of antineoplastic agent paclitaxel. Here, we demonstrated that paclitaxel can bind activate complement component 5a receptor 1 (C5aR1) this binding is crucial in etiology paclitaxel-induced CIPN anaphylaxis. Starting from our previous data demonstrating role interleukin (IL)-8 neuronal toxicity, searched for proteins IL-8 expression and, by using...
Abstract Background and Purpose Cisplatin‐induced sensorineural hearing loss is a significant clinical challenge. Although the potential effects of brain‐derived neurotrophic factor (BDNF) have previously been investigated in some ototoxicity models, its efficacy cisplatin‐induced remains uncertain. This study aimed to investigate therapeutic recombinant human BDNF (rhBDNF) protecting cells against ototoxicity. Experimental Approach Using an vivo model loss, we beneficial transtympanic...
Components of the KDM7 family histone demethylases are implicated in neuronal development and one member, PHF8, is often found to be mutated cases X-linked mental retardation. However, how PHF8 regulates neurodevelopmental processes contributes disease still largely unknown. Here, we show that catalytic activity a homolog Caenorhabditis elegans, JMJD-1.2, required non-cell-autonomously for proper axon guidance. Loss JMJD-1.2 dysregulates transcription Hedgehog-related genes wrt-8 grl-16,...
Post-translational modifications of histones, constitutive components chromatin, regulate chromatin compaction and control all DNA-based cellular processes. C. elegans JMJD-1.2, a member the KDM7 family, is demethylase active towards several lysine residues on Histone 3 (H3), but its contribution in regulating histone methylation germ cells has not been fully investigated. Here, we show that jmjd-1.2 expressed abundantly germline where it controls level 9, 23 27 di-methylation...
Germ cells have evolved unique mechanisms to ensure the transmission of genetically and nongenetically encoded information, whose alteration compromises germ cell immortality. Chromatin factors play fundamental roles in these mechanisms. H3K36 H3K27 methyltransferases shape propagate a pattern histone methylation essential for C. elegans maintenance, but role respective demethylases remains unexplored. Here, we show that jmjd-5 regulates H3K36me2 H3K27me3 levels, preserves germline...
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<p>PDF file - 195K</p>
<p>PDF file - 4604K</p>
<p>PDF file - 195K</p>
<div>Abstract<p><b>Purpose:</b> Carcinoma cells enhance their invasive capacity through dedifferentiation and dissolution of intercellular adhesions. A key activator this process is the ZEB1 transcription factor, which induced in invading cancer by canonical Wnt signaling (β-catenin/TCF4). Tumor invasiveness also entails proteolytic remodeling peritumoral stroma. This study aimed to investigate potential regulation plasminogen system constituted urokinase (uPA), its...
<div>Abstract<p><b>Purpose:</b> Carcinoma cells enhance their invasive capacity through dedifferentiation and dissolution of intercellular adhesions. A key activator this process is the ZEB1 transcription factor, which induced in invading cancer by canonical Wnt signaling (β-catenin/TCF4). Tumor invasiveness also entails proteolytic remodeling peritumoral stroma. This study aimed to investigate potential regulation plasminogen system constituted urokinase (uPA), its...