A5064995309- Congenital Heart Disease Studies
- Congenital heart defects research
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Tracheal and airway disorders
- Cardiovascular and Diving-Related Complications
- Aortic aneurysm repair treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Liver Disease and Transplantation
- Coronary Interventions and Diagnostics
- Aortic Disease and Treatment Approaches
- Cardiac tumors and thrombi
- CNS Lymphoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurological disorders and treatments
- Cardiovascular Conditions and Treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Regulation of Appetite and Obesity
- EEG and Brain-Computer Interfaces
- ATP Synthase and ATPases Research
- Vascular anomalies and interventions
- Vascular Anomalies and Treatments
Showa University Hospital
2019-2021
Showa University
2020
Showa University Northern Yokohama Hospital
2016-2019
Okayama University Hospital
2012-2015
Okayama University
2012-2015
Chikamori Hospital
2009
Osaka Health Science University
1982
Hypoplastic left heart syndrome (HLHS) remains a lethal congenital cardiac defect. Recent studies have suggested that intracoronary administration of autologous cardiosphere-derived cells (CDCs) may improve ventricular function.The aim this study was to test whether delivery CDCs is feasible and safe in patients with hypoplastic syndrome.Between January 5, 2011, 16, 2012, 14 (1.8±1.5 years) were prospectively assigned receive infusion 33.4±8.1 days after staged procedures (n=7), followed by...
Our aim was to assess midterm safety and clinical outcomes of intracoronary infusion cardiosphere-derived cells (CDCs) after staged palliation in patients with hypoplastic left heart syndrome (HLHS).In this prospective, controlled study, 14 consecutive HLHS who were undergoing 2- or 3-stage surgical palliations assigned receive CDC 1 month cardiac surgery (n = 7), followed by 7 allocated a control group standard care alone. The primary end point procedural feasibility safety; the secondary...
The genetic basis of hypoplastic left heart syndrome (HLHS) remains unknown, and the lack animal models to reconstitute cardiac maldevelopment has hampered study this disease. This investigated altered control transcriptional epigenetic programs that may affect development HLHS by using disease-specific induced pluripotent stem (iPS) cells. Cardiac progenitor cells (CPCs) were isolated from patients with congenital diseases generate patient-specific iPS Comparative gene expression analysis...
Congenital heart diseases often involve chronic pressure overload of the right ventricle (RV) which is a major cause RV dysfunction. Pulmonary artery (PA) banding has been used to produce animal models We have devised new and easier method constricting PA compared it directly with partial ligation method.Eight-week-old male Sprague-Dawley rats (240-260 g) were divided into three groups: sham operation, pulmonary (PAL) procedure, half-closed clip (PAC) procedure. function remodeling...
A 56-year-old man, suffering from rapidly worsening general fatigue, dyspnea on exercise and epigastralgia, was referred for evaluation treatment of a cardiac tumor. Transthoracic echocardiography showed 6-cm large mass occupying both the right ventricle atrium. Gallium scintigraphy high uptake in tumor site. Lymphoma highly suggested. Urgent operation performed as much thrombus were removed possible. The postoperative course good, with cessation heart failure. Pathological examination...
Summary This report is of a 63-year-old man with polycythemia vera who developed the Budd-Chiari syndrome due to right hepatic vein stenosis. Diagnosis was made by laparoscopy and liver biopsy, confirmed venography. The patient treated percutaneous transluminal angioplasty, recovered completely from ascites, leg oedema venous stasis. No pulmonary embolism observed. One month after second biopsy showed marked improvement in congestion haemorrhagic necrosis, thereby confirming effectiveness...
Backgrounds: Hypoplastic left heart syndrome (HLHS) is a severe congenital malformation. Objective: The aim of this study to determine whether intracoronary delivery autologous cardiosphere-derived cells (CDCs) was feasible and safe treat the children with HLHS. Methods: Four-teen patients HLHS undergoing staged palliations were prospectively enrolled in trial between January, 2011, 2012. Seven constitutively assigned receive CDCs injection followed by 7 allocated control group standard care...
In cyanotic congenital heart disease, an enlarged aorta often compresses the retroaortic space, resulting in pulmonary artery narrowing. We experienced a case of 10-year-old boy with severe stenosis from narrowed space after Rastelli operation. The right was closely aligned left coronary artery, which made stenting difficult. performed surgical repair including aortic extension interposition graft and elongation ventricular outflow tract (double-outlet extension). This procedure effective...
Abstract Obstruction develops commonly at the acute-angled portion of vessels following palliative surgery, such as systemic–pulmonary shunt (SP shunt), right ventricle–to–pulmonary artery (RV–PA shunt) in Norwood–Sano procedure for hypoplastic left heart syndrome, and cavopulmonary (Glenn) anastomosis. Although balloon angioplasty is a treatment option, dilation with existing straight balloons sometimes ineffective technically complicated because slippage target vessel distortion. In this...
Background: Although a number of studies have uncovered heterozygous mutations in cardiac regulatory genes caused hypoplastic left heart syndrome (HLHS), the identified genetic variants may not be directly correlated with disease development. The aim this study is to determine epigenetic and transcriptional network responsible for myocardial patterning morphogenesis during development HLHS by using patient-derived induced pluripotent stem (iPS) cells. Methods: Five-independent iPS cell lines...
Backgrounds: Hypoplastic left heart syndrome (HLHS) is still one of the severe congenital defects. The first results TICAP trial (NCT01273857) conducted in our hospital have shown that intracoronary infusion cardiosphere-derived cells (CDCs) children with HLHS was feasible and safe; however, mid-term safety efficacy CDCs these patients remain unsolved. aim this study to evaluate injection during period determine factors may be related beneficial effects cardiac function after cell injection....