A5015504521- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- HER2/EGFR in Cancer Research
- Medical Imaging and Pathology Studies
- Eosinophilic Disorders and Syndromes
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Mycobacterium research and diagnosis
- Asthma and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Airway Management and Intubation Techniques
- Tuberous Sclerosis Complex Research
- Cancer, Hypoxia, and Metabolism
- Otolaryngology and Infectious Diseases
- Diagnosis and treatment of tuberculosis
Ehime Medical Center
2023-2024
National Hospital Organization
2023-2024
Ehime University
2010-2023
Uwajima City Hospital
2008
Osaka Health Science University
1982
Neutrophil elastase plays a crucial role in the development of acute lung injury (ALI) patients with systemic inflammatory response syndrome (SIRS). The clinical efficacy neutrophil inhibitor, sivelestat, for ALI associated SIRS has not been convincingly demonstrated. aim this study was to determine if there are features condition that affect sivelestat.This retrospective 110 SIRS. Clinical information, including etiology ALI, number organs failing, scoring systems assessing severity...
Osteopontin (OPN) is a multifunctional protein that plays important roles in cell growth, differentiation, migration and tissue fibrosis. In human idiopathic pulmonary fibrosis murine bleomycin-induced lung fibrosis, OPN upregulated type II alveolar epithelial cells (AEC II). However, the mechanism of induction AEC not fully understood. this study, we demonstrate molecular elucidate functions fibroblasts. Human adenocarcinoma (A549) mouse (MLE12), used as lines for vitro assays, (HPAEpiC)...
A high incidence of interstitial lung disease (ILD) has been reported in patients with advanced non-small cell cancer (NSCLC) treated epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), particularly Japanese populations. previous report from our laboratory demonstrated that KL-6 was a useful serum biomarker to assess the severity drug-induced pneumonitis. Based on these observations, this study conducted evaluate risk factors EGFR-TKIs induced ILD and usefulness...
Background: Neutrophil elastase, alveolar thrombin generation, and fibrin deposition play crucial roles in the development of acute respiratory distress syndrome (ARDS) disseminated intravascular coagulation (DIC). However, usefulness combination therapy with a selective neutrophil elastase inhibitor, sivelestat, recombinant human soluble thrombomodulin (rhTM) for patients ARDS DIC remains unknown. Methods: We conducted retrospective data analysis 142 to assess effects sivelestat combined...
Malignant pleural mesothelioma (MPM), an aggressive and refractory tumor type, is increasing in frequency throughout the world. Peroxisome proliferator activated receptor-γ (PPAR-γ) agonists have anticancer activity against several cancer cell lines vitro vivo. However, there been no reports that PPAR-γ induce growth inhibition of MPM lines. In this study, we investigated inhibitory effect a agonist combination with agent on We examined therapeutic efficacy troglitazone (TGZ) cisplatin human...
EGFR mutant lung cancer responds to tyrosine kinase inhibitors (TKIs), but all patients eventually develop resistance EGFR-TKIs. Herein we report a case of adenocarcinoma that acquired EGFR-TKI with MET amplification and epithelial-to-mesenchymal transition (EMT). A 73-year-old woman was diagnosed harboring an exon 19 deletion. She received gefitinib as second-line therapy. Tumors were reduced 1 month after However, only few months later, chest computed tomography results indicated...
Malignant pleural mesothelioma (MPM) is an aggressive malignancy for which there no approved targeted therapy. We examined the therapeutic efficacy of mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) inhibitors against human MPM cell lines both in vitro orthotopically inoculated into severe combined immunodeficient (SCID) mice. In addition, molecular mechanisms these agents were confirmed vivo. The MEK or PI3K inhibitor suppressed growth a dose-dependent manner...
Summary This report is of a 63-year-old man with polycythemia vera who developed the Budd-Chiari syndrome due to right hepatic vein stenosis. Diagnosis was made by laparoscopy and liver biopsy, confirmed venography. The patient treated percutaneous transluminal angioplasty, recovered completely from ascites, leg oedema venous stasis. No pulmonary embolism observed. One month after second biopsy showed marked improvement in congestion haemorrhagic necrosis, thereby confirming effectiveness...
Purpose: Spirometry is sometimes difficult to perform in elderly patients and those with severe respiratory distress. The forced-oscillation technique (FOT) a simple noninvasive method of measuring impedance. aim this study was determine if FOT data reflect spirometric indices. Patients methods: underwent both spirometry procedures prior inclusion development (n=1,089) validation (n=552) studies. Multivariate linear regression analysis performed identify parameters predictive vital capacity...
Six years ago, a 60-year-old man presented to our hospital with cough and sputum. Upon suspicion of nontuberculous mycobacterial (NTM) infection, he was followed up at hospital. Because the abnormal shadows in bilateral lung fields deteriorated slightly over 6 years, bronchoscopy performed.
症例は67歳, 女性. 平成12年10月の健康診断時に心電図においてI・aVL・V1～V4誘導に陰性T波を認めたため, 精査加療目的で, 11月10日に当科外来を受診した. 諸検査の結果, 肥大型非閉塞性心筋症と診断し, 以後当科外来で経過観察していた. 外来受診時には, すでに陰性T波は改善していた. 平成15年9月上旬に, 胸部不快感を自覚した. 平成15年9月29日の心電図において, I・II・III・aVL・aVF・V2～V6誘導で陰性T波を認めた. 虚血性変化を疑い, 10月7日に当科へ入院した. 心臓カテーテル検査では, 冠動脈に有意な狭窄は認められなかった. MIBG心筋シンチにおいて, 心尖部を中心に集積の低下を認めたため, たこつぼ型心筋障害による心電図変化所見と判断した. その後の経過で陰性T波はほぼ消失した. 今回, たこつぼ型心筋障害によると思われる心電図変化を繰り返した肥大型非閉塞性心筋症の1例を経験したので報告する.
ABSTRACT Bacterial tracheobronchitis is a rare cause of airway stenosis in adults. This report describes 73‐year‐old woman with recent history polysialadenitis, who presented severe obstruction due to infection and tracheal bronchial tissue. Tissue culture the mucosa showed growth methicillin resistant Staphylococcus epidermidis (MRSE). Sputum MRSE, Pseudomonas aeruginosa, Enterobacter cloacae Enterococcus faecalis ; same organisms were cultured from salivary glands. Tracheostomy antibiotic...
A 64-year-old man was admitted to our hospital for purpuric rash, joint pain, and a fever. He had earlier undergone follow-up examination interstitial lung disease. At the current visit, diagnosis immunoglobulin (IgA) vasculitis, based on skin renal biopsy findings. developed sudden breathlessness hemoptysis. Chest computed tomography revealed ground glass opacity in right lower fields, suggesting pulmonary hemorrhaging associated with IgA vasculitis. Despite steroid cyclophosphamide...
Background and Objective: Spirometry is sometimes difficult to perform in elderly patients with cognitive impairment. Forced oscillometry (FOT) a simple, noninvasive technique used for measuring respiratory impedance. The aim of this study was develop regression equations estimate vital capacity (VC), forced (FVC), expiratory volume 1 s (FEV 1.0 ) on the basis FOT indices evaluate accuracy these asthma, chronic obstructive pulmonary disease (COPD), interstitial lung (ILD). Materials Methods:...
An 86-year-old man suffered from COVID-19 and was treated at another hospital. He transferred to our hospital due hemoptysis deterioration of respiratory condition. At hospital, we with steroids antibiotics stopped the administration cilostazol. His condition gradually improved. However, 24 days after onset symptoms, he a sudden pulmonary hemorrhage. Chest computed tomography showed nodular shadow ground glass opacities in right lower upper lobes, respectively. diagnosed COVID-19-associated...