A5079477533- Hearing, Cochlea, Tinnitus, Genetics
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Ear Surgery and Otitis Media
- Cancer Diagnosis and Treatment
- Congenital heart defects research
- Head and Neck Anomalies
- Bone Tumor Diagnosis and Treatments
- Head and Neck Cancer Studies
- Ear and Head Tumors
- Sarcoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Cardiac tumors and thrombi
- Esophageal Cancer Research and Treatment
- Vascular Malformations and Hemangiomas
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Calcium signaling and nucleotide metabolism
- Management of metastatic bone disease
- Acoustic Wave Phenomena Research
- Vascular Tumors and Angiosarcomas
- Biomedical Research and Pathophysiology
- Intraperitoneal and Appendiceal Malignancies
- Otolaryngology and Infectious Diseases
Nihonkai General Hospital
2016-2024
Kyoto University
2004-2020
Kitano Hospital
2007-2016
Kansai Medical University
2006
Jikei University School of Medicine
1990
We evaluated the capacity of clinicopathological factors to predict recurrence in stage II/III colorectal cancer (CRC) patients after curative resection.We retrospectively examined 386 CRC who underwent resections between April 2008 and August 2013. assessed predictive power pre- postoperative tumor marker levels, lymphatic venous invasion, infiltrative growth patterns using Cox's proportional hazards model.Of 206 II 180 III patients, 26 (13%) 46 (26%) respectively, developed recurrences...
Neural stem cells are suggested to possess a highly plastic ability differentiate into several specific cell types, not only neuronal lineages but also other germ layer tissue-specific lineages. To examine whether hair immunophenotypes could be derived from the central nervous system (CNS), we established cultures embryonic day 16.5 fetal rat brain tissues, and analyzed changes in immunohistochemical features of CNS by induction differentiation. The results this study showed that neural...
Transient receptor potential melastatin 8 (TRPM8) is a member of the transient superfamily Ca2+ channels. The aim present study was to clarify TRPM8 expression in reactive lymphoid tissues and mature B-cell neoplasms. Reactive neoplastic were used evaluate by immunohistochemistry reverse transcription-polymerase chain reaction (RT-PCR). TRPM8+ cells frequently detected follicular light zone marginal tissues. Double immunostaining revealed that co-expressed cluster differentiation (CD) 38,...
Damage and loss of hair cells in the inner ear is most frequent cause hearing balance disorders. Mammalian do not regenerate conventional ways. To cell mammalian we transplanted neural stem into explants rat ear. The integrated successfully sensory epithelium vestibular organs, but organ Corti. This method useful to investigate efficient ways transplant
Barrett's esophagus (BE) is a consequence of gastroesophageal reflux disease and predisposed to esophageal adenocarcinoma (EAC). EAC an exemplar model inflammation‐associated cancer. Glucocorticoids suppress inflammation through glucocorticoid receptor (GR) serum‐ glucocorticoid‐induced kinase‐1 (Sgk1) expressions. Therefore, we immunolocalized GR Sgk1 in the adjacent BE tissues studied their association with clinical course 87 patients who underwent surgical resection (N = 58) or endoscopic...
To study the relationship between comedonecrosis formation and morphology, apoptosis, p53, Bcl-2, Ki-67 index E-cadherin expression in early invasive breast cancer.Early cancers were first divided into two groups according to presence (CN+ tumours) or absence (CN- of comedonecrosis. The histological grade, E-cadherin, Ki-67, p53 Bcl-2 cancer-affected area, normal ducts from specimen, then examined.Less tubule gland was seen CN+ tumours than CN- tumours, although grade not different. During...
Objective To analyze whether sufficient energy intake (EI) improves performance of activities daily living (ADL) in patients with hip fracture admitted to rehabilitation hospitals. The adequate amount EI for improving ADL remains unknown. Methods This retrospective cohort study included all (n=234) hospitals Japan. inclusion criteria this were age >65 years and body mass index <30.0 kg/m2. Patients who transferred an acute hospital those missing case data excluded. According the EI,...
The mammalian inner ear mediates hearing and balance during development generates both cochleo-vestibular ganglion neurons sensory epithelial receptor cells, that is, hair cells support cells. Cell marking experiments have shown can originate from a common progenitor. Here, we demonstrate the lineage potential of individual otic cell clones using three lines established by combination limiting dilution gene-marking techniques an embryonic day 12 (E12) rat otocyst. Cell-type specific marker...
The results suggest that early diagnosis and treatment are the most important factors to improve prognosis in oral cancer patients.In this retrospective study we analyzed therapeutic outcome of cancers at out institute.Thirty-one patients with were treated between January 2000 December 2004 Department Otolaryngology-Head Neck Surgery, Kyoto University Hospital. Transoral resection tumor or without neck dissection was performed for (stage I II), while more extensive radical followed by...
Laryngeal necrosis is a rare complication of radiotherapy for early-staged laryngeal or hypopharyngeal cancer. However, when it occurs, there no definitive treatment and laryngectomy frequently required. Here we present case advanced (grade 4, Chandler classification) treated with hyperbaric oxygen (HBO) therapy.A 60-year-old woman received 64.8Gy cancer in combination three courses cisplatin (40mg/body/week). She developed pharyngeal pain progressive dyspnea because edema 3 months after the...
Mucoepidermoid carcinoma (MEC) is the most common salivary gland carcinoma; however, hepatobiliary MEC extremely rare. A 74-year-old patient was diagnosed with after hepatectomy. We considered its origin could be peribiliary glands. Its genome profile similar to rather than standard biliary tract carcinoma.
The mammalian inner ear derives from the otocyst. Molecular mechanisms underlying development are largely unknown. We have isolated a secreted molecule, OC29, rat otocyst cDNA library by signal sequence trap method. OC29 was revealed to be homologue of human WFIKKN. is preferentially expressed in developing and dorsal neural tube. In ear, expression first detectable at embryonic day 11.5 (E11.5), broadly dorsolateral region otocyst, which gives rise vestibular organ. At E12.5, becomes...
Adult-type ovarian granulosa cell tumors (AGCTs) are very rare that account for &#x3c;5% of all carcinomas. AGCTs have low malignancy potential and rarely metastasize 5–30 years after the initial diagnosis. Because time has passed from first surgery because recurrence develops in various locations, differential diagnosis is difficult. In particular, developing greater omentum encountered rarely, it necessary to carefully consider diagnosis, including primary secondary neoplasms. Although...
Abstract Background PEComa is a mesenchymal tumor that can occur in various organs including the uterus and soft tissues. PEComas are composed of perivascular epithelioid cells, angiomyolipoma (AML), clear cell sugar (CCST), lymphangiomyomatosis (LAM) considered lesions same lineage as tumors family. Histologically, common shows solid or sheet-like proliferation cells. This accompanied by an increase number dilated blood vessels. Here, we report case pancreatic with marked inflammatory...
症例は58歳の男性で,2012年7月胃癌に対して開腹幽門側胃切除術を施行した.病理所見はL,Less,tub2>por1,pT1b(SM2)N0M0,pStage IAであり,術後は経過観察を行った.術後12か月のフォローCTにて膵頭部腫瘤性病変を認め局所再発と診断した.腫瘍マーカーの上昇は認めず,画像上その他の再発所見は認めなかったため,2013年8月開腹膵頭十二指腸切除+肝部分切除+横行結腸部分切除を施行した.再手術後,術後補助化学療法として1年間S-1の内服を行い,その後は経過観察を継続し現在再発切除後9年間,無再発生存中である.局所に限局しており,根治的切除が可能であれば,胃癌局所再発に対しても手術も治療の選択肢になると考えられた.
Severe damage by acoustic overstimulation or ototoxins induces inner ear hair cell loss, resulting in permanent hearing loss and balance disorders because regeneration scarcely occurs the sensory organs of mammals. In this study, to evaluate possibilities transplantation therapy for damaged organs, dissociated cultures fetal otocyst cells (FOCs) were established from embryonic day 12.5 (E12.5) rat ears, transplanted into gentamicin-treated explants vestibular epithelia. Two weeks after...
Parathyroidectomy (PTx) is the most powerful therapeutic strategy for secondary hyperparathyroidism in patients with chronic renal failure. However, some cases, identification of pathological parathyroid glands at PTx not easy, resulting sustained hyperparathyroidism. In this study, we employed methylene blue dye to discriminate abnormal 20 cases during PTx.Methylene solution a dose 5mg/kg was administered intravenously time skin incision. 19 (95%), various sizes were stained dark blue,...
We report on two cases of auditory ossicular anomaly and one case traumatic dislocation evaluated with three-dimensional images using MDCT (multidetector-row CT). The first patient was an 18-year-old female, who had noticed hearing impairment in her right ear since she a child. second 32-year-old male, complaining loss his after head injury. third 27-year-old female probably from birth. the patients underwent surgery, their congenital disarticulation were identified intraoperatively, which...
Hepatic angiosarcoma is a very rare disease, but it has poor prognosis. Here, we report the case of 77-year-old man who was referred to our hospital for suspicion hepatocellular carcinoma and cancerous peritonitis. Based on imaging findings, diagnosis spontaneously ruptured hepatic hemangioma made. Six days later, patient transported in state shock an emergency transarterial embolization performed. He underwent lateral segmentectomy 7 later. Histopathologically, he diagnosed with...
Anti-voltage-gated potassium channel complex antibodies-mediated disorder includes Isaacs' syndrome, which is characterized by neuromyotonia, and Morvan encephalopathy autonomic dysfunction. We herein report a patient with syndrome that converted from after thymectomy. The first presented myospasm in all extremities positivity for both anti-leucine-rich glioma inactivated 1 (LGI1) anti-contactin-associated protein like 2 (CASPR2) antibodies subsequently developed thymectomy, was successfully...