A5074420453- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Diabetes and associated disorders
- Light effects on plants
- Plant Molecular Biology Research
- Obstructive Sleep Apnea Research
- Business Process Modeling and Analysis
- Neonatal and fetal brain pathology
- Physiological and biochemical adaptations
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Digital Innovation in Industries
- Diet and metabolism studies
- Time Series Analysis and Forecasting
- EEG and Brain-Computer Interfaces
- Pharmacology and Obesity Treatment
- Sleep and related disorders
- Genetics, Aging, and Longevity in Model Organisms
- Corporate Governance and Management
Technical University of Denmark
2012-2018
Zealand Pharma (Denmark)
2017-2018
Fritz Haber Institute of the Max Planck Society
2016
Charité - Universitätsmedizin Berlin
2009-2014
Stanford University
2014
Glostrup Hospital
2012-2014
Post-translational processes are essential for the generation and dynamics of mammalian circadian rhythms. In particular, phosphorylation key protein PER2 precisely controls period phase oscillations. However, mechanisms underlying that control poorly understood. Here, we identified in a high-throughput RNAi-based genetic screen casein kinase 2 (CK2) as PER2-phosphorylating novel component clock. When CK2 subunits silenced by RNAi or when activity is inhibited pharmacologically, rhythms...
Antarctic krill, Euphausia superba, shapes the structure of Southern Ocean ecosystem. Its central position in food web, ongoing environmental changes due to climatic warming, and increasing commercial interest on this species emphasize urgency understanding adaptability krill its environment. Krill has evolved rhythmic physiological behavioral functions which are synchronized with daily seasonal cycles complex The mechanisms, however, leading these rhythms essentially unknown. Here, we show...
Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set clock genes generate maintain these rhythms with period about 24 hours. Many proteins undergo circadian cycles modifications. Among modifications, protein phosphorylation plays an role in regulating activity, stability intracellular localization components. Several kinases were characterized as regulators clock. However, function...
Many of the automatic sleep spindle detectors currently used to analyze EEG are either validated on young subjects or not thoroughly. The purpose this study is develop and validate a fast reliable detector with high performance in middle aged subjects. An using bandpass filtering approach time varying threshold was developed. validation done epochs from recordings manually scored spindles 13 healthy mean age 57.9 ± 9.7 years. reached sensitivity 84.6% specificity 95.3%. can be obtain...
Background: Currently, no consensus exists on a model describing endogenous glucose production (EGP) as function of glucagon concentrations. Reliable simulations to determine the dose preventing or treating hypoglycemia tune dual-hormone artificial pancreas control algorithm need validated glucoregulatory including effect glucagon. Methods: Eight type 1 diabetes (T1D) patients each received subcutaneous (SC) bolus insulin four study days induce mild followed by SC saline 100, 200, 300 µg...
The purpose of this study is to compare the performance three nonlinear filters in online drift detection continuous glucose monitors. are extended Kalman filter (EKF), unscented (UKF), and particle (PF). They all based on a model glucose-insulin dynamics people with type 1 diabetes. Drift modelled by Gaussian random walk detected statistical tests 90-min prediction residuals filters. had highest average F score 85.9%, smallest delay 84.1%, sensitivity 82.6%, specificity 91.0%.
Abstract Hypoglycaemia remains the main limiting factor in type 1 diabetes management. We developed an insulin‐dependent glucagon dosing regimen for treatment of mild hypoglycaemia based on simulations. A validated glucose–insulin–glucagon model was used to describe seven virtual patients with insulin pump‐treated diabetes. In each simulation, one ten different and individualized subcutaneous boluses administered decrease plasma glucose (PG) from 7.0 ≤3.9 mmol/l. Insulin levels were...
Background and aims: Recently genetic studies suggested that the circadian system is tightly coupled with mechanisms controlling metabolism. This regulation consists of complexly integrated regulatory loops, as regulators metabolic pathways are themselves regulated by different nutritional signals. Secretion insulin sensitivity on control. Here we tested hypothesis, directly or via metabolic-induced changes may regulate clocks.
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