A5062948558- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Cytokine Signaling Pathways and Interactions
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Malaria Research and Control
- Mitochondrial Function and Pathology
- Cardiac Ischemia and Reperfusion
- Parasites and Host Interactions
- Melanoma and MAPK Pathways
- Probiotics and Fermented Foods
- Drug Transport and Resistance Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Bacterial biofilms and quorum sensing
- Eosinophilic Disorders and Syndromes
- Antimicrobial Resistance in Staphylococcus
- Reproductive tract infections research
- Viral gastroenteritis research and epidemiology
- Ubiquitin and proteasome pathways
- Fibroblast Growth Factor Research
- Immunotherapy and Immune Responses
- ATP Synthase and ATPases Research
- Antibiotic Resistance in Bacteria
St. George's University
2016-2024
Cadila Healthcare (India)
2021
Jawaharlal Nehru University
2009-2020
Tamil Nadu Veterinary and Animal Sciences University
2018
Kansas State University
2016
Northwestern University
2010-2014
University of Chicago
2007
Mitochondrial complex II is a tumor suppressor comprised of four subunits (SdhA, SdhB, SdhC, and SdhD). Mutations in any these should disrupt enzymatic activity, yet defects SdhA produce bioenergetic deficiency while or SdhD induce formation. The mechanisms underlying differences are not known. We show that the inhibition distal II, either pharmacologically via RNA interference increases normoxic reactive oxygen species (ROS) production, hypoxia-inducible factor alpha (HIF-alpha)...
ZyCoV-D is a DNA vaccine candidate, which comprises plasmid carrying spike-S gene of SARS-CoV-2 virus along with coding for signal peptide. The spike(S) region includes the receptor-binding domain (RBD), binds to human angiotensin converting Enzyme (ACE)-2 receptor and mediates entry inside cell.We conducted single-center, open-label, non-randomized, Phase 1 trial in India between July 2020 October 2020. Healthy adults aged 18 55 years were sequentially enrolled allocated one four treatment...
IFNγ and TNFα are potent inhibitors of hematopoiesis have been implicated in the pathophysiology bone marrow failure myelodysplastic syndromes (MDS). We examined role protein kinase R (PKR) generation inhibitory effects these myelosuppressive cytokines on hematopoiesis. Our data demonstrate that PKR is rapidly phosphorylated/activated response to engagement or receptors normal human hematopoietic progenitors. Such important for suppressive Pharmacological targeting using a specific inhibitor...
Infections with tick-borne pathogens belonging to Anaplasma/Ehrlichia in various vertebrate hosts are a persistent problem resulting nonspecific clinical signs during early infection. Diagnosis of single and multi-infections these pathogens, causing diseases companion/agricultural animals people, remains challenge. Traditional methods diagnosis, such as microscopy serology, have low sensitivity specificity. Polymerase chain reaction (PCR) assays widely used detect early-phase infections,...
Tick-borne bacteria, Ehrlichia canis, Anaplasma platys, and chaffeensis are significant pathogens of dogs worldwide, coinfections E. canis A. platys common in on the Caribbean islands. We developed evaluated performance a multiplex bead-based assay to detect antibodies peptides from Grenada, West Indies, where infections endemic. Peptides outer membrane proteins P30 OMP-1X P28-19/P28-14 were coupled magnetic beads. The peptide detected experimentally infected with chaffeensis, but not an...
The presence of microorganisms in food is predictable, which causes significant threat to the public health. Staphylococcus aureus one such foodborne bacterial pathogen that cuses various outbreaks worldwide. incidence S. samples common and it has been characterized as economically important pathogens. In present study, was investigated ready eat meat products (n=100) purchased from retail market Chennai. Overall 20% different products. prevalence were 25.6%, 33.3%, 23.8% 3.7% for chicken,...
Background: Clinical infections caused by multidrug-resistant pathogenic bacteria are associated with increased morbidity and mortality, imposing a severe economic burden. Pseudomonas aeruginosa, gram-negative bacterium, had demonstrated prominent level of acquired antimicrobial resistance to its selective antimicrobials. Currently, there is no updated information about the susceptibility pattern aeruginosa in Grenada. Hence, present study aimed determine P. from clinical isolates dogs...
Aim: This study aimed to find out the prevalence of active infection Leptospira spp. in Rattus norvegicus from Grenada, West Indies, through polymerase chain reaction (PCR). Materials and Methods: One hundred forty-nine rats were trapped, anesthetized their kidneys collected aseptically. DNA was extracted kidney tissue each rat. PCR performed targeting LipL32 gene. Eighteen PCR-positive amplicons for gene segment purified sent direct sequencing facility MCLAB (South San Francisco, USA)....
The aim of the study was to detect and genetically characterize Arcobacter butzleri in pet red-footed tortoises suspected for Campylobacter spp., using molecular techniques. A written consent from tortoise owners obtained, after explaining advantages research Grenada. Fecal samples were collected 114 five parishes country cultured spp. selective culture A. isolated 4.39% tortoises. Total thirteen isolates obtained; all identified as by a universal species-specific Polymerase Chain Reaction...
Malaria parasites use an extensive secretory pathway to export a number of proteins remodel the host cells. It is involved in trafficking many crucial for parasite's survival. Despite presence classical intricacies it still remain elusive. The Endoplasmic reticulum (ER) nerve center and different organelles outside parasite. In higher eukaryotes, ER membrane bound transcription factors such as SREBP are reported get processed en route migrate nucleus under influence specific cues. However,...