A5053864933- Vector-borne infectious diseases
- Immune Response and Inflammation
- Vector-Borne Animal Diseases
- Veterinary Practice and Education Studies
- Innovations in Medical Education
- Viral Infections and Vectors
- Problem and Project Based Learning
- Immune Cell Function and Interaction
- Veterinary Equine Medical Research
- Animal health and immunology
- Ion Transport and Channel Regulation
- Drug Transport and Resistance Mechanisms
- Sport Psychology and Performance
- Pharmacological Effects and Toxicity Studies
- Insect and Pesticide Research
- Immune cells in cancer
- Toxoplasma gondii Research Studies
- Health and Medical Research Impacts
- Natural product bioactivities and synthesis
- Exercise and Physiological Responses
- Sports Performance and Training
- Immunotherapy and Immune Responses
- Biomedical and Engineering Education
- Advances in Oncology and Radiotherapy
- Coccidia and coccidiosis research
St. George's University
2012-2024
Utrecht University
2003-2012
Westfälische Hochschule
2000
Pattern recognition receptors (PRRs) on host cells detect pathogens to activate innate immunity which, in turn, initiates inflammatory and adaptive immune responses. Successful activation of PRRs is, therefore, critical controlling infections driving pathogen-specific immunity, but overactivity causes systemic inflammation, which is detrimental the host. Here we review PRR literature as it relates horses speculate role may play sepsis endotoxaemia.
This study shows which hard tick species (Ixodidae) were found on domestic horses in the Netherlands 2008 -2009, and what potential pathogens these ticks carried.In period 130 collected, classified screened for presence of DNA from specific tick-borne using PCR-RLB.The numbers various were: 68 Ixodes ricinus, 58 spp.(57 nymphs 1 larva), 2 Dermacentor reticulatus Hyalomma marginatum.DNA Borrelia valaisiana was detected 49 % ticks, B. afzelii 22 %, burgdorferi sensu stricto garinii 3...
Abstract The recent changes in curricula veterinary medicine have changed the delivery and focus on pharmacology therapeutics, resulting a perceived lack of knowledge therapeutic decision making graduates. To aid pharmacologists clinicians teaching clinical pharmacology, core competencies were drafted by working group. Following this process, Delphi study was performed to come consensus day‐1 therapeutics. described could be useful variety stakeholders including those worldwide. Secondly,...
A total of 47 horses, and 120 ticks that had been removed from them, were tested for infections with the zoonotic pathogens Borrelia burgdorferi Anaplasma phagocytophilum after removal one or more attached (n = 120), which subsequently examined presence these agents. .All horses at time tick 6-12 weeks later; thirteen again 9-23 months removal.Serology was performed using an IFAT, ELISA a commercially available rapid test.Initially, 45% positive B. antibodies 23% A. phagocytophilum; 15%...
In renal proximal tubules, the basolateral organic anion [p-aminohippurate (PAH)] transporter is functionally coupled to sodium-dependent dicarboxylate transporter. This study was undertaken elucidate whether protein kinases differentially modulate activities of these transporters. isolated S(2) segments tubules microdissected from rabbit kidneys, we investigated transporters are regulated by tyrosine kinases, phosphatidylinositol 3-kinase (PI3K), and mitogen-activated kinase (MAPK). The...
Toxoplasma gondii is responsible for one of the most prevalent infections in people. T. profilin (TgPr) a protein integral to parasite movement and cellular invasion. Murine TLRs has been described bind TgPr. Furthermore, more recently, human TLR5 recognise recombinant TgPr, as well bacterial flagellin. In addition humans, infects farm animals, but little information available about its innate recognition. We aimed investigate whether, similarly their orthologue, bovine porcine could also be...
The competency-based veterinary education (CBVE) framework describes essential domains of competence and related abilities for graduates. Translating these outcomes into daily teaching is a challenge, particularly regarding the underpinning basic clinical science knowledge. In this article, we identified lack specific reference to selection use drugs within CBVE framework; requires pharmacological knowledge pharmacology-specific competencies. To fill gap provide guidance pharmacology...
Abstract Several different tick species are known to infest horses. Aside from causing serious health and welfare issues, including anaemia, ill thrift, immunosuppression, ticks can transmit a variety of important, sometimes zoonotic, pathogens. The successful prevention treatment infestations have been described, but the information is scarce and, in many instances, anecdotal. Here we describe practical affordable infestation by using abamectin‐impregnated cattle ear tags affixed safety...
Abstract— It has been demonstrated that the basolateral organic anion (PAH) transporter and sodium‐dependent dicarboxylate of rabbit renal proximal tubules are regulated differentially. A variety protein kinases shown to be involved in regulation transport while uptake, which first is coupled functionally, not inlluenced by these kinases. This study was undertaken elucidate whether respective activities modulated differentially phosphatases as well. The experiments were performed on isolated...