The incidence of acute renal failure, defined by the risk, injury, or failure criteria RIFLE (risk, loss, and end-stage kidney disease), in 66 patients who received colistimethate sodium was 45%, 21% stopped therapy because nephrotoxicity. should be used future to allow for comparison nephrotoxicity among studies.

The pathophysiology of anti-glomerular basement membrane (anti-GBM) disease before clinical presentation is unknown. presence anti-GBM, anti-proteinase 3 (PR3), and anti-myeloperoxidase (MPO) antibodies associate with the at time diagnosis, but little known about these autoantibodies diagnosis. We used serum samples from Department Defense Serum Repository to conduct a case-control study involving 30 patients diagnosed anti-GBM healthy controls matched for age, gender, race, age samples....

Patients with immunoglobulin light chain amyloidosis (AL amyloidosis) generally present advanced organ dysfunction and have a high risk of early death. We sought to characterize monoclonal (M-Ig) chains before clinical presentation AL amyloidosis.We obtained prediagnostic sera from 20 cases healthy controls matched for age, sex, race, age serum sample the Department Defense Serum Repository. protein electrophoresis immunofixation free (FLC) analysis were performed on all samples.An M-Ig was...

Significance Statement Primary membranous nephropathy (MN) is an autoimmune glomerular disease associated with nephrotic syndrome and poor kidney prognosis. Autoantibodies against the M-type phospholipase A2 receptor (PLA2R-AB) are present at diagnosis in about 70% of cases. However, when PLA2R-AB first appear their trajectory unknown. The authors used Department Defense Serum Repository to describe prediagnostic evolution over time. In most patients who tested positive for antibodies,...

Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder associated with vascular dysfunction and fibrotic changes in the skin, vasculature internal organs. Although serologic abnormalities are an important diagnostic tool for SSc, little known about whether autoantibodies precede clinical diagnosis. Here we investigated presence of before SSc diagnosis assessed certain might associate future onset scleroderma renal crisis (SRC), potentially fatal complication disease. Using...

Extramedullary tissue infiltrates of acute myeloid leukemia are rare and often difficult to recognize in routine paraffin-embedded sections. Since appropriate therapy for these tumors depends on their precise identification, we have studied a series tissues infiltrated with primitive cells using monoclonal polyclonal antibodies capable labeling the myeloid/monocytic system The current retrospective study involved from 15 patients (eight men seven women) mean age 51 years (range, 23-77). A...

To determine whether Seraph-100 (Exthera Medical Corporation, Martinez, CA) treatment provides clinical benefit for severe coronavirus disease 2019 cases that require mechanical ventilation and vasopressor support.The first two patients in the United States treated with novel device. These were reviewed by Food Drug Administration prior to granting an emergency use authorization of 2019.Case series.Vasopressor dose, mean arterial pressure, temperature, interleukin-6, C-reactive protein,...

The mRNA coronavirus disease 2019 (COVID-19) vaccines induce an IgG response that prevents people from contracting severe acute respiratory syndrome 2 (SARS-CoV-2). Interestingly, there are now at least 6 cases of gross hematuria reported in patients with a history biopsy-proven IgA nephropathy (IgAN), involving both vaccines.1Negrea L. Rovin B.H. Gross following vaccination for nephropathy.Kidney Int. 2021; 99: 1487Abstract Full Text PDF PubMed Scopus (80) Google Scholar, 2Rahim S.E.G. Lin...

Objective. Systemic sclerosis (SSc) is a disease of autoimmunity, fibrosis, and vasculopathy. Scleroderma renal crisis (SRC) one the most severe complications. Corticosteroid exposure, presence anti-RNA polymerase III antibodies (ARA), skin thickness, significant tendon friction rubs are among known risk factors at SSc diagnosis for developing future SRC. Identification additional clinical characteristics laboratory findings could expand improve profile SRC diagnosis. Methods. In this...

Elevated anti-double-stranded DNA (dsDNA) antibody and C-reactive protein are associated with proliferative lupus nephritis (PLN). Progression of quantitative anti-dsDNA in patients PLN has not been compared that systemic erythematosus (SLE) without LN before diagnosis. The temporal relationship between elevation also evaluated.This case-control Department Defense Serum Repository (established 1985) study longitudinal prediagnostic levels 23 biopsy-proven (Walter Reed Army Medical Center,...

The subclinical pathogenesis of granulomatosis with polyangiitis (GPA) has not been completely elucidated. Proteinase 3 (PR3) antibodies are strongly associated GPA, but have evaluated before disease presentation.This was a retrospective case-control serum bank study in which PR3 and C-reactive protein (CRP) up to three longitudinal samples for 27 GPA patients diagnosis (1 day-19 years) were compared controls whose matched age, sex, race. This analyzed all American College Rheumatology...

Goodpasture syndrome (GP) is a pulmonary-renal characterized by autoantibodies directed against the NC1 domains of collagen IV in glomerular and alveolar basement membranes. Exposure cryptic epitope thought to occur via disruption sulfilimine crosslinks domain that are formed peroxidasin-dependent production hypobromous acid. Peroxidasin, heme peroxidase, has significant structural overlap with myeloperoxidase (MPO), MPO-ANCA present both before at GP diagnosis some patients. We determined...

Subcutaneous estrogen pellet implantation is commonly practiced to induce tumor promotion in nude (Nu- FOXnl nu ) mice for xenograft modeling. Twelve of 23, 18-week-old developed dysuria after implantation. Physical examination revealed variably distended abdomens with palpable bladders. All were euthanatized and postmortem examinations made. Blood samples the collected, serum concentration was measured. Postmortem variable dilation urinary bladder unilateral or bilateral dilations ureters...

Mortality and CKD risk have not been described in military casualties with post-traumatic AKI requiring RRT suffered the Iraq Afghanistan wars.

Plasma metanephrines (PMN) are highly sensitive for diagnosis of pheochromocytoma, but the natural history PMN before pheochromocytoma has not been previously described. The aim study was to compare progression matched healthy and essential hypertension disease controls.A retrospective case-control Department Defense Serum Repository (DoDSR) study.We performed a DoDSR that compared three longitudinal pre-diagnostic 30 biopsy-proven cases age, sex, race, age serum sample controls. Predominant...

FSGS is a heterogeneic glomerular disease. Risk factors for kidney disease ESKD and the effect of immunosuppression treatment (IST) has varied in previously published cohorts. These cohorts were limited by relatively small case numbers, short follow-up, lack racial/ethnic diversity, mix adult pediatric patients, renin-angiotensin-aldosterone system (RAAS) inhibition, or subgroup analysis IST.We compared demographics, clinical characteristics, histopathology, IST to long-term renal survival...

Scleroderma Renal Crisis (SRC) is associated with significant morbidity and mortality. While prednisone strongly SRC, there are no previous large cohort studies that have evaluated ace inhibitor (ACEi) calcium channel blocker (CCB), angiotensin receptor (ARB), endothelin (ERB), non-steroidal anti-inflammatory drug (NSAID), fluticasone, or mycophenolate mofetil (MMF) use in systemic sclerosis (SSc) the risk of SRC. In this retrospective study entire military electronic medical record between...

Background . The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have reported. Methods We performed a retrospective case-control Department Defense Serum Repository (DoDSR) study comparing MPO-ANCA in longitudinal serum samples for 23 biopsy confirmed patients to DoDSR identified age, sex, race, and age matched healthy SLE without...

Key Points The entire extracellular domain of thrombospondin type-1 7A (THSD7A) in the luciferase immunoprecipitation system immunoassay was required to detect autoantibodies with high sensitivity membranous nephropathy (MN). In THSD7A-seropositive MN patients, changes antibody levels precede clinical status. Seropositive THSD7A antibodies were detected some patients considered be secondary autoimmunity or cancer. Background Pathogenic against are present approximately 3% Compared PLA2R...

Direct renin inhibitors (DRIs) block the activation of alternative complement pathway in vitro and could be a treatment option for refractory hypertension atypical hemolytic uremic syndrome (aHUS). A 20-year-old male presented with primary aHUS complicated by end-stage renal disease malignant despite being on five antihypertensive medications at maximum dose. Only partial response was achieved aliskiren eculizumab, but after increasing to supratherapeutic dose, medication reduced, platelets...