A5017902870- Cell death mechanisms and regulation
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- FOXO transcription factor regulation
- Diet and metabolism studies
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Kruppel-like factors research
- Metabolomics and Mass Spectrometry Studies
- Phagocytosis and Immune Regulation
- PARP inhibition in cancer therapy
- Cellular transport and secretion
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Stress, Anesthesia, and Immune Response
- Adipose Tissue and Metabolism
- Digestive system and related health
- Heat shock proteins research
- Biochemical Analysis and Sensing Techniques
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Apelin-related biomedical research
- Peroxisome Proliferator-Activated Receptors
- Cancer-related gene regulation
- Autophagy in Disease and Therapy
University of Kentucky
2017-2024
Universidade Estadual de Campinas (UNICAMP)
2021-2023
The Graduate Center, CUNY
2017-2019
Universidade Federal de Goiás
2018
Abstract Background The continuous proliferation of intestinal stem cells followed by their tightly regulated differentiation to epithelial is essential for the maintenance gut barrier and its functions. How these processes are tuned diet microbiome an important, but poorly understood question. Dietary soluble fibers, such as inulin, known ability impact bacterial community epithelium, consumption has been usually associated with health improvement in mice humans. In this study, we tested...
The induction of tumor suppressor proteins capable cancer cell apoptosis represents an attractive option for the re-purposing existing drugs. We report that anti-malarial drug, chloroquine (CQ), is a robust inducer Par-4 secretion from normal cells in mice and patients clinical trial. CQ-inducible triggers paracrine also inhibits metastatic growth. CQ induces via classical secretory pathway requires activation p53. Mechanistically, p53 directly Rab8b, GTPase essential vesicle transport to...
Glucose-Regulated Protein 78 (GRP78), also known as BiP (Binding Immunoglobulin Protein), is a member of the Hsp70 family chaperone proteins that essential for embryonic development. GRP78 highly conserved across species, and localized primarily in endoplasmic reticulum, where it regulates protein folding activates unfolded response pathway (UPR) during stress conditions [[6]Lee A.S. The glucose-regulated proteins: induction clinical applications.Trends Biochem Sci. 2011; 26: 504-510Summary...
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show conventional knockout (Par-4
Abstract Prostate apoptosis response-4 (Par-4) is a tumor suppressor which protects against neoplastic transformation. Remarkably, Par-4 capable of inducing selectively in cancer cells without affecting the normal cells. In this study, we found that recombinant protein had limited serum persistence mice may diminish its anti-tumor activity vivo. To improve vivo performance short-lived protein, aimed to develop novel, long-lasting form with extended sequence, denoted as Par-4Ex, desirable...
Prostate apoptosis response-4 (Par-4, also known as PAWR) is a ubiquitously expressed tumor suppressor protein that induces selectively in cancer cells, while leaving normal cells unaffected. Our previous studies indicated genetic loss of Par-4 promoted hepatic steatosis, adiposity, and insulin-resistance chow-fed mice. Moreover, low plasma levels are associated with obesity human subjects. The mechanisms underlying rodents humans multi-faceted, those adipogenesis can be functionally...