The prevalence of nanoplastics (NPs) and sulfonamide antibiotics (SAs) in the aquatic environment is potentially harmful to environment, these pollutants are often present form composite ones, thereby introducing more complex effects hazards environment. Therefore, it crucial investigate toxic individual target their mixtures. In this study, we used Scenedesmus obliquus as test organisms, two types NPs: polystyrene (PS) amine-modified (NH

Four quinolone antibiotics (ciprofloxacin (CIP), enrofloxacin (ENR), sparfloxacin (SPA), gatifloxacin (GAT)) and their binary mixtures at environmentally relevant concentrations exhibited time-dependent hormesis on Vibrio qinghaiensis sp.-Q67 (Q67). The study aims to investigate the toxicity of low-dose pollutants occurrence hormesis. These indicators, total protein (TP), reactive oxygen species (ROS), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) luminescence-related...

This study investigates the 96 hr toxicity and physiological effects of eight azole fungicides on Raphidocelis subcapitata (R. subcapitata). The findings revealed significant differences in levels among these fungicides, with hierarchy as follows: difenoconazole ≈ tetraconazole fuberidazole > metconazole terrazole triflumizole flutriafol hymexazol. Increased concentrations corresponded decreased cellular activity inhibited algal growth, highlighting concentration-dependent nature toxicity....

The hormesis effect has gradually become a research focus in environmental science and toxicology due to its unique phenomenon of low-concentration stimulation high-concentration inhibition. combined toxicity antibiotics their regulatory effects on microorganisms are areas that warrant significant attention. In this study, doxycycline hydrochloride (DXC), sulfamethoxazole (SMX) sulfamethazine (SMZ) were used as the objects, Scenedesmus obliquus was indicator organism study action laws at...

Risk assessment of single pollutants has been extensively studied. However, the co-exposure in a real environment may pose greater risk than chemicals. In this study, concentration addition-based quotients were applied to 15 organochlorine pesticides (OCPs) mixtures (α-hexachlorocyclohexane (HCH), β-HCH, γ-HCH, δ-HCH, heptachlor, aldrin, heptachlor epoxide, chlordane, α-endosulfan, p,p'-dichloro-diphenyl-dichloroethylene, endrin, β-endosulfan, p,p'-dichloro-diphenyl-dichloroethane,...

Antibiotics may be exposed in a mixed state natural environments. The toxicity of antibiotic mixtures exhibits time-dependent characteristics, and data on the is also relatively lacking. In this study, toxicities 45 binary composed five antibiotics were investigated against Vibrio qinghaiensis sp.-Q67 (Q67) at multiple exposure times (4, 6, 8, 10, 12 h). Quantitative structure–activity relationship (QSAR) models developed for predicting mixtures. results showed that best QSAR presented...

To indentify Mn/Cd co-hyperaccumulatoion in Celosia argentea Linn., 2 pot experiments were conducted using Cd/Mn-amended and real contaminated soils, respectively. The interaction between Cd Mn with regard to their accumulation the plants was also assessed. results indicated that C. can simultaneously hyperaccumulate Mn. maximum concentrations leaves 276 29,000 mg/kg, application significantly enhanced biomass production shoots (p < 0.05). However, addition did not reduce plants....

The prediction and mechanism analysis of hepatotoxicity contaminants, because their various phenotypes complex mechanisms, is still a key problem in environmental research. We applied toxicological network method to predict the three hexabromocyclododecane (HBCD) diastereoisomers (α-HBCD, β-HBCD, γ-HBCD) explore potential mechanisms. First, we collected related genes found that those were significantly localized human interactome. Therefore, these form disease module hepatotoxicity. also...

Abstract Background Co-exposure of multiple quaternary ammonium compounds (QACs) is widely present in the aquatic environment. The knowledge about their toxicities to microorganism at low concentration lacking. This study aims test toxic response Vibrio qinghaiensis Q 67 (12-h exposure) individual and mixtures QACs by long-term microplate toxicity analysis method (L-MTA). Results Hormetic effects were observed for five 12-h exposure 67. maximum stimulation effect − 339.66% was 0.00561 mol/L...

Abstract It is acknowledged that azole fungicides may release into the environment and pose potential toxic risks. The combined toxicity interactions of fungicide mixtures, however, are still not fully understood. toxicities its 225 binary mixtures 126 multi‐component on Chlorella pyrenoidosa were performed in this study. results demonstrated negative logarithm 50% effect concentration (pEC 50 ) 10 to at 96 h ranged from 4.23 (triadimefon) 7.22 (ketoconazole), while pEC values 351 3.91 7.44....

As algae are extremely sensitive to heavy-metal ions and can be critical biological indicators in the toxicity analyses conducted by environmental health researchers, this paper explores sensitivity temporal of three species green algae: Scenedesmus obliquus, Chlorella pyrenoidosa, Selenastrum capricornutum. The method time-dependent microplate analysis was used systematically investigate changes toxicities green-algae induced different concentrations cadmium (Cd). chlorophyll a content,...

Ampicillin (AMP) and cefazolin (CZO) are commonly used β-lactam antibiotics which extensively globally produced. Additionally, AMP CZO known to have relatively high ecotoxicity. Notably, the mix of creates a synergistic effect that is more harmful environment, how exposure AMP-CZO can induce synergism in algae remains virtually unknown. To yield comprehensive mechanistic insights into chemical toxicity, including dose–response relationships variations species sensitivity, integration...

Background: The prediction of the drug-induced liver injury (DILI) chemicals is still a key issue adverse drug reactions (ADRs) that needs to be solved urgently in development. development novel method with good predictive capability and strong mechanism interpretation focus topic exploring DILI. Objective: With help systems biology network analysis techniques, class descriptors can reflect influence targets pathogenesis DILI established. Then machine learning model developed between these...

Several hundred disinfection byproducts (DBPs) in drinking water have been identified, and are known to potentially adverse health effects. There toxicological data gaps for most DBPs, the predictive method may provide an effective way address this. The development of in-silico model toxicology endpoints DBPs is rarely studied. main aim present study develop quantitative structure-activity relationship (QSAR) models reactive toxicities 50 five bioassays X-Microtox, GSH+, GSH-, DNA+ DNA-....