A5005669125- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Animal Virus Infections Studies
- Genetic factors in colorectal cancer
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Pharmacogenetics and Drug Metabolism
- Lymphoma Diagnosis and Treatment
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Minerals Flotation and Separation Techniques
- Bamboo properties and applications
- Tree Root and Stability Studies
- Pharmacological Effects and Toxicity Studies
- Kruppel-like factors research
- Mitochondrial Function and Pathology
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Plant Parasitism and Resistance
- Amoebic Infections and Treatments
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
Huashan Hospital
2024
Zhejiang University
2012-2024
Harbin Veterinary Research Institute
2013-2024
Chinese Academy of Agricultural Sciences
2022-2024
Xi'an Honghui Hospital
2014-2024
Xi'an Jiaotong University
2014-2024
University of California, San Diego
2016-2024
University of Alberta
2023-2024
Fudan University
2003-2024
University of Illinois Urbana-Champaign
2022-2024
The recently developed AlphaFold2 (AF2) algorithm predicts proteins’ 3D structures from amino acid sequences. open AlphaFold protein structure database covers the complete human proteome. Using an industry-leading molecular docking method (Glide), we investigated virtual screening performance of 37 common drug targets, each with AF2 and known holo apo DUD-E data set. In a subset 27 targets where are suitable for refinement, show comparable early enrichment active compounds (avg. EF 1%: 13.0)...
Herbivory is fundamental to the regulation of both global food webs and extent agricultural crop losses. Induced plant responses herbivores promote resistance often involve perception specific herbivore-associated molecular patterns (HAMPs); however, precisely defined receptors elicitors associated with herbivore recognition remain elusive. Here, we show that a receptor confers signaling defense outputs in response HAMP common caterpillar oral secretions (OS). Staple crops, including cowpea...
Understanding tissue alterations at an early stage following traumatic brain injury (TBI) is critical for management and limiting severe consequences from secondary injury. We investigated the microstructural metabolic profiles using in vivo diffusion tensor imaging (DTI) proton magnetic resonance spectroscopy (1H MRS) 2 4 h a controlled cortical impact rat 7.0 Tesla animal MRI system compared to baseline. Significant decrease mean diffusivity (MD) increased fractional anisotropy (FA) was...
J. Neurochem. (2010) 114 , 820–831. Abstract Acetyl‐ l ‐carnitine (ALCAR) is an endogenous metabolic intermediate that facilitates the influx and efflux of acetyl groups across mitochondrial inner membrane. Exogenously administered ALCAR has been used as a nutritional supplement also experimental drug with reported neuroprotective properties effects on brain metabolism. The aim this study was to determine oxidative metabolism in immature rat forebrain. Metabolism studied 21–22 day‐old at 15,...
The SLC22 family of OATs, OCTs, and OCTNs is emerging as a central hub endogenous physiology. Despite often being referred to "drug" transporters, they facilitate the movement metabolites key signaling molecules. An in-depth reanalysis supports reassignment these proteins into eight functional subgroups, with four new subgroups arising from previously defined OAT subclade: OATS1 (SLC22A6, SLC22A8, SLC22A20), OATS2 (SLC22A7), OATS3 (SLC22A11, SLC22A12, Slc22a22), OATS4 (SLC22A9, SLC22A10,...
The multispecific organic anion transporters, OAT1 (SLC22A6) and OAT3 (SLC22A8), the main kidney elimination pathways for many common drugs, are often considered to have largely-redundant roles. However, whereas examination of metabolomics data from Oat-knockout mice (Oat1 Oat3KO) revealed considerable overlap, over a hundred metabolites were increased in plasma one or other these knockout mice. Many relatively unique components distinct biochemical signaling pathways, including those...
The recently developed AlphaFold2 (AF2) algorithm predicts proteins’ 3D structures from amino acid sequences. open AlphaFold Protein Structure Database covers the complete human proteome. It shows great potential to provide structural information enable and enhance existing new drug discovery projects. Using an industry-leading molecular docking method (Glide), we benchmarked virtual screening performance of 28 common targets each with AF2 structure known holo apo DUD-E dataset. show...
A quinoline-functionalized amphiphilic fluorogenic probe was synthesized which selectively detects trivalent ions <italic>viz.</italic> Al<sup>3+</sup>, Fe<sup>3+</sup>, Cr<sup>3+</sup>, Ru<sup>3+</sup> and Au<sup>3+</sup> through a fluorescence turn on signal.
Background Reliance on just one drug to treat the prevalent tropical disease, schistosomiasis, spurs search for new drugs and targets. Inhibitors of human cyclic nucleotide phosphodiesterases (huPDEs), including PDE4, are under development as novel a range chronic indications asthma, obstructive pulmonary disease Alzheimer's disease. One class huPDE4 inhibitors that has yielded marketed is benzoxaboroles (Anacor Pharmaceuticals). Methodology/Principal findings A phenotypic screen involving...
Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals humans, imposing great threats to public safety animal health. Porcine deltacoronavirus (PDCoV), newly emerging enteropathogenic coronavirus, causes severe diarrhea suckling piglets all over world poses potential risks cross-species transmission. Here, we use PDCoV as model CoVs illustrate reciprocal regulation between infection host antiviral responses. In...
Transcription factors from the NusG family bind to elongating RNA polymerase enable synthesis of long RNAs in all domains life. In bacteria, frequently co-exists with specialized paralogs that regulate expression a small set targets, many which encode virulence factors. Escherichia coli RfaH is exemplar this regulatory mechanism. contrast NusG, freely binds polymerase, exists structurally distinct autoinhibitory state polymerase-binding site buried at interface between two domains. Binding...
Plant elicitor peptides (Peps) are conserved regulators of defense responses and models for the study damage-associated molecular pattern-induced immunity. Although present as multigene families in most species, functional relevance these remains largely undefined. While Arabidopsis Peps appear redundant function, previous work examining Pep-induced maize (Zm) implied specificity function. To better define function individual ZmPeps their cognate receptors (ZmPEPRs), activities were examined...
Different therapeutic nucleic acids (TNAs) can be unified in a single structure by their elongation with short oligonucleotides designed to self-assemble into acid nanoparticles (NANPs). With this approach, cocktails precisely controlled composition and stoichiometry of active ingredients delivered the same diseased cells for enhancing pharmaceutical action. In work, an additional nanotechnology-based option that enlists biocompatible NANP-encoded platform patient-specific immunorecognition...
CYP2C8 plays an important role in the metabolism of various drugs, such as paclitaxel, repaglinide and ibuprofen. Polymorphisms gene were shown to influence interindividual differences pharmacokinetics ibuprofen enantiomers. In this study, three allelic variants (CYP2C8.2, CYP2C8.3 CYP2C8.4) wild-type (CYP2C8.1) co-expressed for first time with human cytochrome P450 oxidoreductase (POR) b5 by using a baculovirus-assisted insect cell expression system. Further, effects genotype-phenotype...
Purpose This study evaluated the longitudinal metabolic alterations after neonatal hypoxia-ischemia (HI) in rats and tested neuroprotective effect of acetyl-L-carnitine (ALCAR) using vivo proton short-TE Point-RESolved Spectroscopy method. Methods Rice-Vannucci model was used on 7-day-old Sprague-Dawley rats. Data were acquired from contralateral ipsilateral cortex hippocampus, respectively at 4 time points (24-h, 72-h, 7-days, 28-days) post-HI. The subcutaneous administration ALCAR (100...
Recent works have reported that long non-coding RNAs (lncRNAs) play critical roles in tumorigenesis and prognosis of cancers, suggesting the potential utility lncRNAs as cancer prognostic markers. However, lncRNA signatures predicting survival patients with clear cell renal carcinoma (ccRCC) remain unknown. In this study, we attempted to identify their values ccRCC. Using expression profiling data 440 ccRCC tumors from The Cancer Genome Atlas (TCGA) data, a five-lncRNA signature (AC069513.4,...
Bladder cancer stem cells (BCSCs), exhibiting self-renewal and differentiation capacities, may contribute to the tumor initiation, metastasis, recurrence drug resistance of bladder cancer. However, underlying functional mechanisms BCSCs remain be clarified. In this study, we describe differentially-expressed mRNAs, lncRNAs, circRNAs in compared with that non-stem (BCNSCs) through transcriptome microarray data analysis using patients' specimens. CircRNA_103809, top one among highly expressed...