A5090998275- Pediatric Urology and Nephrology Studies
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Ear Surgery and Otitis Media
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Sinusitis and nasal conditions
- Respiratory viral infections research
- Urinary Bladder and Prostate Research
- Bacterial Infections and Vaccines
- Bladder and Urothelial Cancer Treatments
- Streptococcal Infections and Treatments
- Kidney Stones and Urolithiasis Treatments
- Pediatric health and respiratory diseases
- Antibiotic Use and Resistance
- Meta-analysis and systematic reviews
- Pharmaceutical studies and practices
- Gut microbiota and health
- Allergic Rhinitis and Sensitization
- Health and Medical Research Impacts
- Ethics and Legal Issues in Pediatric Healthcare
- Otolaryngology and Infectious Diseases
- Tracheal and airway disorders
- Hearing Impairment and Communication
- Health Sciences Research and Education
University of Pittsburgh
2016-2025
Children's Hospital of Pittsburgh
2016-2025
University of Pittsburgh Medical Center
2009-2024
Smt. N.H.L. Municipal Medical College
2024
Patients First
2023
National Institute on Deafness and Other Communication Disorders
2023
The Centers
2016
Boston Children's Hospital
2006-2016
University of Wisconsin–Madison
2016
Children's Hospital of Philadelphia
2016
Recommendations vary regarding immediate antimicrobial treatment versus watchful waiting for children younger than 2 years of age with acute otitis media.We randomly assigned 291 6 to 23 months age, media diagnosed the use stringent criteria, receive amoxicillin-clavulanate or placebo 10 days. We measured symptomatic response and rates clinical failure.Among who received amoxicillin-clavulanate, 35% had initial resolution symptoms by day 2, 61% 4, 80% 7; among placebo, 28% 54% 74% 7 (P=0.14...
OBJECTIVES: To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile symptomatic UTIs received no antimicrobial prophylaxis. METHODS: This 2-year, multisite prospective cohort study included 305 aged to 71 months with vesicoureteral reflux (VUR) receiving placebo the RIVUR (Randomized Intervention Vesicoureteral Reflux) 195 VUR observed CUTIE (Careful Urinary Tract Infection Evaluation) study. Primary exposure was...
Existing data regarding the association between delayed initiation of antimicrobial therapy and development renal scarring are inconsistent.To determine whether delay in for febrile urinary tract infections (UTIs) is associated with occurrence severity scarring.Retrospective cohort study that combined from 2 previously conducted longitudinal studies (the Randomized Intervention Children With Vesicoureteral Reflux trial Careful Urinary Tract Infection Evaluation Study). younger than 6 years a...
Limiting the duration of antimicrobial treatment constitutes a potential strategy to reduce risk resistance among children with acute otitis media.We assigned 520 children, 6 23 months age, media receive amoxicillin-clavulanate either for standard 10 days or reduced 5 followed by placebo days. We measured rates clinical response (in systematic fashion, on basis signs and symptomatic response), recurrence, nasopharyngeal colonization, we analyzed episode outcomes using noninferiority...
Little generalizable information is available on the outcomes of children diagnosed with bladder and bowel dysfunction (BBD) after a urinary tract infection (UTI). Our objectives were to describe clinical characteristics BBD examine effects patient in without vesicoureteral reflux (VUR).We combined data from 2 longitudinal studies (Randomized Intervention for Children With Vesicoureteral Reflux Careful Urinary Tract Infection Evaluation) which <6 years age first or second UTI followed years....
We sought to determine factors associated with the absence of pyuria in symptomatic children whose urine culture was positive for a known uropathogen.We obtained data on evaluated at Children's Hospital Pittsburgh emergency department between 2007 and 2013 symptoms urinary tract infection (UTI) who had paired urinalysis cultures. excluded an unknown or bag collection method, major genitourinary anomalies, immunocompromising conditions, multiple organisms culture. chose single,...
A child's health, positive perceptions of the research team and consent process, altruistic motives play significant roles in decision-making process for parents who their child to enroll clinical research. This study identified that nonconsenting were better educated, had private insurance, showed lower levels altruism, less understanding design.To determine factors associated with parental participation a randomized, placebo-controlled trial.Cross-sectional survey conducted from July 2008...
Accurately estimating the probability of urinary tract infection (UTI) in febrile preverbal children is necessary to appropriately target testing and treatment.To develop test a calculator (UTICalc) that can first estimate UTI based on clinical variables then update laboratory results.Review electronic medical records aged 2 23 months who were brought emergency department Children's Hospital Pittsburgh, Pennsylvania. An independent training database comprising 1686 patients between January...
Importance The large overlap between symptoms of acute sinusitis and viral upper respiratory tract infection suggests that certain subgroups children being diagnosed with sinusitis, subsequently treated antibiotics, derive little benefit from antibiotic use. Objective To assess if therapy could be appropriately withheld in prespecified subgroups. Design, Setting, Participants Randomized clinical trial including 515 aged 2 to 11 years based on criteria. was conducted February 2016 April 2022...
Our goal is to determine if antimicrobial prophylaxis with trimethoprim/sulfamethoxazole prevents recurrent urinary tract infections and renal scarring in children who are found have vesicoureteral reflux after a first or second infection.The Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR) study double-blind, randomized, placebo-controlled trial. Six hundred aged 2 72 months will be recruited from both primary subspecialty care settings at clinical trial centers...
Although prior studies have suggested that the risk of renal scarring gradually increases with each febrile urinary tract infection (UTI), recent and detailed data are lacking.To evaluate how is associated number UTIs.A post hoc analysis was performed from June 2018 to April 2019 collected in context 2 multicenter prospective (RIVUR [Randomized Intervention for Children With Vesicoureteral Reflux], conducted 2007 2013, CUTIE [Careful Urinary Tract Infection Evaluation], May 2008 October...
Official recommendations differ regarding tympanostomy-tube placement for children with recurrent acute otitis media.