Precise delivery of therapeutic cells to the desired site in vivo is an emerging and promising cellular therapy precision medicine. This paper presents development a magnet-driven image-guided degradable microrobot that can precisely deliver engineered stem for orthotopic liver tumor treatment. The employs burr-like porous sphere structure made with synthesized composite fulfill degradability, mechanical strength, magnetic actuation capability simultaneously. be spontaneously released from...

This paper presents a passive wireless sensor for simultaneously and remotely measuring pressure temperature under harsh environments. The consists of dual LC (inductor capacitor) resonant circuit, one without cavity the other with capacitor sensing, respectively. low-temperature co-fired ceramic technology is used to fabricate sensor, making it suitable high-temperature environment operations. Experimental results show prototype has sensitivity 8.15 kHz/°C 1.96 MHz/Bar up 400°C.

Capsule robots have gained increasing prominence in gastroscopy for their diagnostic capabilities and noninvasive accessibility to narrow passages with reduced risks. Magnetic positioning plays a crucial role mapping the trajectory of capsule robot targeting specific areas interest. However, current magnetic technology is limited by challenges incompatibility external manipulation systems, power size constraints, resolution caused accumulated errors during attitude estimation. Here, we...

Objective: The application of in vivo microrobot navigation has received considerable attention from the field precision therapy, which uses microrobots living organisms. Methods: This study investigates using optical coherence tomography (OCT) imaging feedback. electromagnetic gradient generated by a home-made manipulation system is magnetically modeled. With this model, magnetic force acting on calculated, and relationship between velocity characterized. Results: Results are verified...

The propulsive efficiency and biodegradability of wireless microrobots play a significant role in facilitating promising biomedical applications. Mimicking biological matters is way to improve the performance microrobots. Among diverse locomotion strategies, undulatory propulsion shows remarkable agility. This work proposes novel magnetically powered hydrogel-based biodegradable microswimmer. microswimmer fabricated integrally by 3D laser lithography based on two-photon polymerization from...

The temperature sensor presented in this paper is based on a microwave dielectric resonator, which uses alumina ceramic as substrate to survive harsh environments. resonant frequency of the resonator determined by relative permittivity ceramic, monotonically changes with temperature. A rectangular aperture etched surface works both an incentive and coupling device. broadband slot antenna fed coplanar waveguide utilized interrogation wirelessly detect signal using radio-frequency...

Microrobots with simultaneously improved degradability and mechanical strength are highly demanded in performing vivo delivery tasks clinical applications. The properties of contradictory for many materials used to make microrobots. This article proposes a new design that can result 3D cell culture microrobots from the following perspectives. First, microrobot is using triangle patterns replace hexagon pattern structure, which provide more supporting grids obtain increased strength. Second,...

In this work, a wireless passive LC resonant sensor based on DuPont 951 ceramic is proposed and tested in developed high-temperature/pressure complex environment. The test results show that the measured frequency varies approximately linearly with applied pressure; simultaneously, high temperature causes pressure signal drift changes response sensitivity. Through theoretical analysis of structure model, it found increase dielectric constant decrease Young's modulus are main affect...

Optical cell manipulation has become increasingly valuable in cell-based assays. In this paper, we demonstrate the translational and rotational of filamentous cells using multiple cooperative microrobots automatically driven by holographic optical tweezers. The photodamage due to direct irradiation laser beam can be effectively avoided. proposed method will enable fruitful biomedical applications where precise less are required.

Abstract The bottom‐up assembly of premagnetized microgels offers remarkable flexibility in programmability, material selection, and complexity for fabricating programmable magnetic soft machines with discrete 3D magnetization profiles. However, the current microgel bonding encounters challenges due to utilization adhesives attachment, biocompatibility vivo applications, need elevated temperature self‐healing materials. Here, an approach is presented that leverages N‐hydroxysuccinimide...

Optical tweezers are widely used for noninvasive and precise micromanipulation of living cells to understand biological processes. By focusing laser beams on cells, direct cell manipulation with optical can achieve high precision flexibility. However, exposure the beam lead negative effects cells. These phenomena also known as photobleaching photodamage. In this study, we proposed a new indirect approach combined robot-aided holographic tweezer system 3D nano-printed microtool. The microtool...

A novel reentrant cavity-microstrip patch antenna integrated wireless passive pressure sensor was proposed in this paper for high temperature applications. The cavity analyzed from aspects of distributed model and equivalent lumped circuit model, on the basis which an optimal structure with a rectangular microstrip to better transmit/receive signals. In paper, fabricated resistant alumina ceramic silver metalization weld sealing, it measured hermetic metal tank nitrogen loading. It verified...

A high-temperature pressure sensor realized by the post-fire metallization on zirconia ceramic is presented. The signal can be read out wirelessly through magnetic coupling between reader antenna and due to that equivalent an inductive-capacitive (LC) resonance circuit which has a pressure-sensitive frequency. Considering excellent mechanical properties in environment, multilayered tapes were used fabricate structure. Owing its low resistivity, sliver paste was chosen form electrical via...

Cell-carrying magnet-driven microrobots are easily affected by blood flow or body fluids during transportation in the body, and thus cells often fall off from microrobots. To reduce loss of loaded cells, we developed a microrobot with bioactive nanostructured titanate surface (NTS), which enhances cell adhesion. The was fabricated using 3D laser lithography coated nickel for magnetic actuation. Then, titanium external generation an NTS through reactions NaOH solution. Enhanced adhesion may...

Combining patterning coculture technique with microfluidics enables the reconstruction of complex in-vivo system to facilitate in-vitro studies on cell-cell and cell-environment interactions. However, simple versatile approaches for cells microfluidic platforms remain lacking. In this study, a novel gravitational sedimentation-based approach is presented achieve ultra-simple flexible cell platform, where multiple types can be patterned simultaneously form well-organized coculture. contrast...

Purpose – The purpose of this paper is to propose a pressure-, temperature- and acceleration-sensitive structure-integrated inductor-capacitor (LC) resonant ceramic sensor fulfill the measurement multi-parameters, such as pressure, temperature acceleration, simultaneously in automotive, aerospace aeronautics industries. Design/methodology/approach ceramic-based multi-parameter was composed three LC tanks, which have their frequencies sensitive acceleration separately. Two aspects from...

The accurate delivery of precise amounts drugs to a specific location can considerably affect various clinical applications. control drug amount and position is crucial successful delivery. This paper proposes the use poly(lactide-co-glycolicacid) (PLGA)-based microspheres contain an optical tweezer manipulator transport these drug-containing their targeted sites in vivo. were delivered by PLGA-based yolk sac zebrafish embryos, sustained release was observed examine anti-angiogenesis...

This article introduces the fabrication technology processes of capacitive pressure sensor based on low temperature co-fired ceramic (LTCC) material. Filling cavity with different materials as a sacrificial layer is mainly discussed, and two are chosen in fabrication. It found that filled polyimide expands largely during sintering, while carbon ESL49000 material more preferable to keep flat. Finally, structure leaving without an air evacuation channel designed tested built-up environment,...

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Dual-parameter inductive-capacitive (LC) resonant sensor is gradually becoming the measurement trend in complex harsh environments; however, coupling between inductors greatly affects readout signal, which becomes very difficult to resolve by means of simple mathematical tools. By changing values specific variables a MATLAB code, influence coils on signal analyzed. Our preliminary conclusions underline that antenna but it simultaneously influences other signal. When<mml:math...

Scientists have been able to trap and move biological cells by using optical tweezers through the momentum of a focused laser beam. However, in conventional direct cell manipulation involving tweezers, must be exposed photon flux consequently become damaged during process. The indirect has attracted many concerns, but filamentous remains poorly addressed. In this study, we propose an approach for indiret transportation cells. A microtool is designed fabricated two-photon polymerization....